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The effect of systemic ibuprofen on gingival inflammation in humans

Abstract: This clinical trial investigated the influence of short-term ibuprofen therapy on the early phase of the treatment of adult chronic periodontitis. The subjects were 17 patients in good general health referred for specialist periodontal treatment, having moderate chronic adult periodontitis...

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Main Authors: Taiyeb Ali, T.B., Waite, I.M.
Format: Article
Language:English
Published: 1993
Subjects:
RK Dentistry
Online Access:http://eprints.um.edu.my/3652/1/The_effect_of_systemic_ibuprofen_on_gingival_inflammation_in_humans.pdf
http://eprints.um.edu.my/3652/
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spelling my.um.eprints.36522012-09-04T06:21:05Z http://eprints.um.edu.my/3652/ The effect of systemic ibuprofen on gingival inflammation in humans Taiyeb Ali, T.B. Waite, I.M. RK Dentistry Abstract: This clinical trial investigated the influence of short-term ibuprofen therapy on the early phase of the treatment of adult chronic periodontitis. The subjects were 17 patients in good general health referred for specialist periodontal treatment, having moderate chronic adult periodontitis. A series of assessments were made every 2 weeks over an 8-week period, including evaluations of oral hygiene, gingival inflammation and probing pocket depths. All participants received oral hygiene instruction, and following baseline examinations, had half the dentition, chosen at random, treated by scaling and root planing. The patients were randomly distributed into 2 groups, a test group receiving a 14-day course of 800 mg ibuprofen daily, in 4 divided doses, and a control group who did not receive any drug regime. At the 2-week assessment following the drug regime, significantly greater reduction in gingival bleeding, colour and pocketing was detected in the test compared with the control group. The beneficial effects were less evident thereafter. Although clinical application of the regime used in this study would not be justified by these results, further research into anti-inflammatory agents as an adjunct in the treatment of periodontal diseases could be considered, in the light of the beneficial effect on gingivitis in the early phase of periodontal treatment reported. 1993 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3652/1/The_effect_of_systemic_ibuprofen_on_gingival_inflammation_in_humans.pdf Taiyeb Ali, T.B. and Waite, I.M. (1993) The effect of systemic ibuprofen on gingival inflammation in humans. Journal of Clinical Periodontology, 20 (10). pp. 723-728. ISSN 0303-6979 10.1111/j.1600-051X.1993.tb00697.x
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic RK Dentistry
spellingShingle RK Dentistry
Taiyeb Ali, T.B.
Waite, I.M.
The effect of systemic ibuprofen on gingival inflammation in humans
description Abstract: This clinical trial investigated the influence of short-term ibuprofen therapy on the early phase of the treatment of adult chronic periodontitis. The subjects were 17 patients in good general health referred for specialist periodontal treatment, having moderate chronic adult periodontitis. A series of assessments were made every 2 weeks over an 8-week period, including evaluations of oral hygiene, gingival inflammation and probing pocket depths. All participants received oral hygiene instruction, and following baseline examinations, had half the dentition, chosen at random, treated by scaling and root planing. The patients were randomly distributed into 2 groups, a test group receiving a 14-day course of 800 mg ibuprofen daily, in 4 divided doses, and a control group who did not receive any drug regime. At the 2-week assessment following the drug regime, significantly greater reduction in gingival bleeding, colour and pocketing was detected in the test compared with the control group. The beneficial effects were less evident thereafter. Although clinical application of the regime used in this study would not be justified by these results, further research into anti-inflammatory agents as an adjunct in the treatment of periodontal diseases could be considered, in the light of the beneficial effect on gingivitis in the early phase of periodontal treatment reported.
format Article
author Taiyeb Ali, T.B.
Waite, I.M.
author_facet Taiyeb Ali, T.B.
Waite, I.M.
author_sort Taiyeb Ali, T.B.
title The effect of systemic ibuprofen on gingival inflammation in humans
title_short The effect of systemic ibuprofen on gingival inflammation in humans
title_full The effect of systemic ibuprofen on gingival inflammation in humans
title_fullStr The effect of systemic ibuprofen on gingival inflammation in humans
title_full_unstemmed The effect of systemic ibuprofen on gingival inflammation in humans
title_sort effect of systemic ibuprofen on gingival inflammation in humans
publishDate 1993
url http://eprints.um.edu.my/3652/1/The_effect_of_systemic_ibuprofen_on_gingival_inflammation_in_humans.pdf
http://eprints.um.edu.my/3652/
_version_ 1643687169052639232
score 13.211869

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