Staff View: Detrimental effects of UVB on retinal pigment epithelial cells and its role in age-related macular degeneration

Detrimental effects of UVB on retinal pigment epithelial cells and its role in age-related macular degeneration

Retinal pigment epithelial (RPE) cells are an essential part of the human eye because they not only mediate and control the transfer of fluids and solutes but also protect the retina against photooxidative damage and renew photoreceptor cells through phagocytosis. However, their function necessitate...

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Main Authors:	Mahendra, Camille Keisha, Tan, Loh Teng Hern, Pusparajah, Priyia, Htar, Thet Thet, Chuah, Lay-Hong, Lee, Vannajan Sanghiran, Low, Liang Ee, Tang, Siah Ying, Chan, Kok-Gan, Goh, Bey Hing
Format:	Article
Published:	Hindawi Publishing Corporation 2020
Subjects:	Q Science (General) QH301 Biology
Online Access:	http://eprints.um.edu.my/36488/
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spelling	my.um.eprints.364882023-11-30T07:53:11Z http://eprints.um.edu.my/36488/ Detrimental effects of UVB on retinal pigment epithelial cells and its role in age-related macular degeneration Mahendra, Camille Keisha Tan, Loh Teng Hern Pusparajah, Priyia Htar, Thet Thet Chuah, Lay-Hong Lee, Vannajan Sanghiran Low, Liang Ee Tang, Siah Ying Chan, Kok-Gan Goh, Bey Hing Q Science (General) QH301 Biology Retinal pigment epithelial (RPE) cells are an essential part of the human eye because they not only mediate and control the transfer of fluids and solutes but also protect the retina against photooxidative damage and renew photoreceptor cells through phagocytosis. However, their function necessitates cumulative exposure to the sun resulting in UV damage, which may lead to the development of age-related macular degeneration (AMD). Several studies have shown that UVB induces direct DNA damage and oxidative stress in RPE cells by increasing ROS and dysregulating endogenous antioxidants. Activation of different signaling pathways connected to inflammation, cell cycle arrest, and intrinsic apoptosis was reported as well. Besides that, essential functions like phagocytosis, osmoregulation, and water permeability of RPE cells were also affected. Although the melanin within RPE cells can act as a photoprotectant, this photoprotection decreases with age. Nevertheless, the changes in lens epithelium-derived growth factor (LEDGF) and autophagic activity or application of bioactive compounds from natural products can reverse the detrimental effect of UVB. Additionally,in vivostudies on the whole retina demonstrated that UVB irradiation induces gene and protein level dysregulation, indicating cellular stress and aberrations in the chromosome level. Morphological changes like retinal depigmentation and drusen formation were noted as well which is similar to the etiology of AMD, suggesting the connection of UVB damage with AMD. Therefore, future studies, which include mechanism studies viain vitroorin vivoand other potential bioactive compounds, should be pursued for a better understanding of the involvement of UVB in AMD. Hindawi Publishing Corporation 2020-08 Article PeerReviewed Mahendra, Camille Keisha and Tan, Loh Teng Hern and Pusparajah, Priyia and Htar, Thet Thet and Chuah, Lay-Hong and Lee, Vannajan Sanghiran and Low, Liang Ee and Tang, Siah Ying and Chan, Kok-Gan and Goh, Bey Hing (2020) Detrimental effects of UVB on retinal pigment epithelial cells and its role in age-related macular degeneration. Oxidative Medicine and Cellular Longevity, 2020. ISSN 1942-0900, DOI https://doi.org/10.1155/2020/1904178 <https://doi.org/10.1155/2020/1904178>. 10.1155/2020/1904178
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	Q Science (General) QH301 Biology
spellingShingle	Q Science (General) QH301 Biology Mahendra, Camille Keisha Tan, Loh Teng Hern Pusparajah, Priyia Htar, Thet Thet Chuah, Lay-Hong Lee, Vannajan Sanghiran Low, Liang Ee Tang, Siah Ying Chan, Kok-Gan Goh, Bey Hing Detrimental effects of UVB on retinal pigment epithelial cells and its role in age-related macular degeneration
description	Retinal pigment epithelial (RPE) cells are an essential part of the human eye because they not only mediate and control the transfer of fluids and solutes but also protect the retina against photooxidative damage and renew photoreceptor cells through phagocytosis. However, their function necessitates cumulative exposure to the sun resulting in UV damage, which may lead to the development of age-related macular degeneration (AMD). Several studies have shown that UVB induces direct DNA damage and oxidative stress in RPE cells by increasing ROS and dysregulating endogenous antioxidants. Activation of different signaling pathways connected to inflammation, cell cycle arrest, and intrinsic apoptosis was reported as well. Besides that, essential functions like phagocytosis, osmoregulation, and water permeability of RPE cells were also affected. Although the melanin within RPE cells can act as a photoprotectant, this photoprotection decreases with age. Nevertheless, the changes in lens epithelium-derived growth factor (LEDGF) and autophagic activity or application of bioactive compounds from natural products can reverse the detrimental effect of UVB. Additionally,in vivostudies on the whole retina demonstrated that UVB irradiation induces gene and protein level dysregulation, indicating cellular stress and aberrations in the chromosome level. Morphological changes like retinal depigmentation and drusen formation were noted as well which is similar to the etiology of AMD, suggesting the connection of UVB damage with AMD. Therefore, future studies, which include mechanism studies viain vitroorin vivoand other potential bioactive compounds, should be pursued for a better understanding of the involvement of UVB in AMD.
format	Article
author	Mahendra, Camille Keisha Tan, Loh Teng Hern Pusparajah, Priyia Htar, Thet Thet Chuah, Lay-Hong Lee, Vannajan Sanghiran Low, Liang Ee Tang, Siah Ying Chan, Kok-Gan Goh, Bey Hing
author_facet	Mahendra, Camille Keisha Tan, Loh Teng Hern Pusparajah, Priyia Htar, Thet Thet Chuah, Lay-Hong Lee, Vannajan Sanghiran Low, Liang Ee Tang, Siah Ying Chan, Kok-Gan Goh, Bey Hing
author_sort	Mahendra, Camille Keisha
title	Detrimental effects of UVB on retinal pigment epithelial cells and its role in age-related macular degeneration
title_short	Detrimental effects of UVB on retinal pigment epithelial cells and its role in age-related macular degeneration
title_full	Detrimental effects of UVB on retinal pigment epithelial cells and its role in age-related macular degeneration
title_fullStr	Detrimental effects of UVB on retinal pigment epithelial cells and its role in age-related macular degeneration
title_full_unstemmed	Detrimental effects of UVB on retinal pigment epithelial cells and its role in age-related macular degeneration
title_sort	detrimental effects of uvb on retinal pigment epithelial cells and its role in age-related macular degeneration
publisher	Hindawi Publishing Corporation
publishDate	2020
url	http://eprints.um.edu.my/36488/
_version_	1784511821610221568
score	13.211869

Detrimental effects of UVB on retinal pigment epithelial cells and its role in age-related macular degeneration

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