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Co-regulative effects of chitosan-fennel seed extract system on the hormonal and biochemical factors involved in the polycystic ovarian syndrome

There is a renewed interest in the application of chitosan-based drug delivery systems over the last few years. In this study, the ionic gelation method was used to prepare chitosan-engaged tripolyphosphate ions, as the cross linking molecule, (Chit-TPP) and concurrent loading of the biomolecules of...

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Main Authors: Bayrami, Abolfazl, Shirdel, Arezoo, Pouran, Shima Rahim, Mahmoudi, Fariba, Habibi-Yangjeh, Aziz, Singh, Ramesh, Raman, Abdul Aziz Abdul
Format: Article
Published: Elsevier 2020
Subjects:
T Technology (General)
TJ Mechanical engineering and machinery
Online Access:http://eprints.um.edu.my/36204/
https://www.scopus.com/record/display.uri?eid=2-s2.0-85089755124&origin=resultslist&sort=plf-f&src=s&sid=ea3df32f0d92f7c07683ccde1d11c36a&sot=b&sdt=b&s=TITLE-ABS-KEY%28Co-regulative+effects+of+chitosan-fennel+seed+extract+system+on+the+hormonal+and+biochemical+factors+involved+in+the+polycystic+ovarian+syndrome%29&sl=159&sessionSearchId=ea3df32f0d92f7c07683ccde1d11c36a
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spelling my.um.eprints.362042023-11-29T02:41:53Z http://eprints.um.edu.my/36204/ Co-regulative effects of chitosan-fennel seed extract system on the hormonal and biochemical factors involved in the polycystic ovarian syndrome Bayrami, Abolfazl Shirdel, Arezoo Pouran, Shima Rahim Mahmoudi, Fariba Habibi-Yangjeh, Aziz Singh, Ramesh Raman, Abdul Aziz Abdul T Technology (General) TJ Mechanical engineering and machinery There is a renewed interest in the application of chitosan-based drug delivery systems over the last few years. In this study, the ionic gelation method was used to prepare chitosan-engaged tripolyphosphate ions, as the cross linking molecule, (Chit-TPP) and concurrent loading of the biomolecules of the ethanolic extract of fennel, Foeniculum vulgare, seed (FEC@NBC). The samples were characterized by SEM, DLS, TGA, FTIR, XRD, GC-MS, and zeta potential, and their effects on the related hormonal and biochemical factors of the rats with polycystic ovarian syndrome (PCOS) were assessed. The estradiol valerate-induced PCOS in female rats was confirmed by vaginal smear test and subsequent histological screening. The PCOS-induced rats were treated by fennel seed extract (FSX), Chit-TPP, and FEC@NBC. The process of treatment was monitored by measuring the serum levels of testosterone, luteinizing hormone, follicle-stimulating hormone, insulin, glucose, high-density lipoprotein cholesterol, total cholesterol, and total triglyceride after 16 days of treatment and compared with healthy control and untreated PCOS-control groups. The FEC@NBC administration contributed to the remarkable hormonal, glucose, and lipid profile regulation in the rats with PCOS. The significance of FEC@NBC performance in dealing with PCOS complications compared to that of the only extract could be resulted from the effective targeted delivery and stability of phytomolecules when encapsulated in Chit-TPP. Elsevier 2020-12 Article PeerReviewed Bayrami, Abolfazl and Shirdel, Arezoo and Pouran, Shima Rahim and Mahmoudi, Fariba and Habibi-Yangjeh, Aziz and Singh, Ramesh and Raman, Abdul Aziz Abdul (2020) Co-regulative effects of chitosan-fennel seed extract system on the hormonal and biochemical factors involved in the polycystic ovarian syndrome. Materials Science and Engineering C, 117. ISSN 09284931, DOI https://doi.org/10.1016/j.msec.2020.111351 <https://doi.org/10.1016/j.msec.2020.111351>. https://www.scopus.com/record/display.uri?eid=2-s2.0-85089755124&origin=resultslist&sort=plf-f&src=s&sid=ea3df32f0d92f7c07683ccde1d11c36a&sot=b&sdt=b&s=TITLE-ABS-KEY%28Co-regulative+effects+of+chitosan-fennel+seed+extract+system+on+the+hormonal+and+biochemical+factors+involved+in+the+polycystic+ovarian+syndrome%29&sl=159&sessionSearchId=ea3df32f0d92f7c07683ccde1d11c36a 10.1016/j.msec.2020.111351
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic T Technology (General)
TJ Mechanical engineering and machinery
spellingShingle T Technology (General)
TJ Mechanical engineering and machinery
Bayrami, Abolfazl
Shirdel, Arezoo
Pouran, Shima Rahim
Mahmoudi, Fariba
Habibi-Yangjeh, Aziz
Singh, Ramesh
Raman, Abdul Aziz Abdul
Co-regulative effects of chitosan-fennel seed extract system on the hormonal and biochemical factors involved in the polycystic ovarian syndrome
description There is a renewed interest in the application of chitosan-based drug delivery systems over the last few years. In this study, the ionic gelation method was used to prepare chitosan-engaged tripolyphosphate ions, as the cross linking molecule, (Chit-TPP) and concurrent loading of the biomolecules of the ethanolic extract of fennel, Foeniculum vulgare, seed (FEC@NBC). The samples were characterized by SEM, DLS, TGA, FTIR, XRD, GC-MS, and zeta potential, and their effects on the related hormonal and biochemical factors of the rats with polycystic ovarian syndrome (PCOS) were assessed. The estradiol valerate-induced PCOS in female rats was confirmed by vaginal smear test and subsequent histological screening. The PCOS-induced rats were treated by fennel seed extract (FSX), Chit-TPP, and FEC@NBC. The process of treatment was monitored by measuring the serum levels of testosterone, luteinizing hormone, follicle-stimulating hormone, insulin, glucose, high-density lipoprotein cholesterol, total cholesterol, and total triglyceride after 16 days of treatment and compared with healthy control and untreated PCOS-control groups. The FEC@NBC administration contributed to the remarkable hormonal, glucose, and lipid profile regulation in the rats with PCOS. The significance of FEC@NBC performance in dealing with PCOS complications compared to that of the only extract could be resulted from the effective targeted delivery and stability of phytomolecules when encapsulated in Chit-TPP.
format Article
author Bayrami, Abolfazl
Shirdel, Arezoo
Pouran, Shima Rahim
Mahmoudi, Fariba
Habibi-Yangjeh, Aziz
Singh, Ramesh
Raman, Abdul Aziz Abdul
author_facet Bayrami, Abolfazl
Shirdel, Arezoo
Pouran, Shima Rahim
Mahmoudi, Fariba
Habibi-Yangjeh, Aziz
Singh, Ramesh
Raman, Abdul Aziz Abdul
author_sort Bayrami, Abolfazl
title Co-regulative effects of chitosan-fennel seed extract system on the hormonal and biochemical factors involved in the polycystic ovarian syndrome
title_short Co-regulative effects of chitosan-fennel seed extract system on the hormonal and biochemical factors involved in the polycystic ovarian syndrome
title_full Co-regulative effects of chitosan-fennel seed extract system on the hormonal and biochemical factors involved in the polycystic ovarian syndrome
title_fullStr Co-regulative effects of chitosan-fennel seed extract system on the hormonal and biochemical factors involved in the polycystic ovarian syndrome
title_full_unstemmed Co-regulative effects of chitosan-fennel seed extract system on the hormonal and biochemical factors involved in the polycystic ovarian syndrome
title_sort co-regulative effects of chitosan-fennel seed extract system on the hormonal and biochemical factors involved in the polycystic ovarian syndrome
publisher Elsevier
publishDate 2020
url http://eprints.um.edu.my/36204/
https://www.scopus.com/record/display.uri?eid=2-s2.0-85089755124&origin=resultslist&sort=plf-f&src=s&sid=ea3df32f0d92f7c07683ccde1d11c36a&sot=b&sdt=b&s=TITLE-ABS-KEY%28Co-regulative+effects+of+chitosan-fennel+seed+extract+system+on+the+hormonal+and+biochemical+factors+involved+in+the+polycystic+ovarian+syndrome%29&sl=159&sessionSearchId=ea3df32f0d92f7c07683ccde1d11c36a
_version_ 1783876653246578688
score 13.211869

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