Evaluation of DNA binding and topoisomerase I inhibitory activities of 16 `-Decarbomethoxydihydrovoacamine from Tabernaemontana Corymbosa

An iboga-vobasine bisindole alkaloid, 16 `-decarbomethoxydihydrovoacamine (1) isolated from the stem bark extract of Tabernaemontana corymbosa exhibited strong cytotoxicity against colorectal cancer cell lines in our preliminary study. As an initial step to elucidate its anti-proliferative mechanism...

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Bibliographic Details
Main Authors: Tan, Chun Hoe, Sim, Dawn Su Yin, Heng, Mok Piew, Lim, Siew Huah, Low, Yun Yee, Kam, Toh Seok, Sim, Kae Shin
Format: Article
Published: Wiley 2020
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Online Access:http://eprints.um.edu.my/36182/
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