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Antioxidant activity and acute toxicity of two Lagenaria siceraria (Molina) Standl. Varieties from Sudan Antioksidacijska aktivnost in akutna toksičnost dveh sort vodnjače (Lagenaria siceraria (Molina) Standl.) Iz Sudana

The present study was conducted to evaluate the antioxidant capacity and acute toxicity of the methanol extract of two Lagenaria siceraria (Molina) Standl. varieties of dried seeds, Sweet gourd Water Jug (WJ) and bitter gourd Basket Ball (BB). The seed extracts were tested for their total phenolic c...

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Main Authors: Mariod, Abdalbasit Adam, Mustafa, Makarim Mutasim Mohamed, Nour, Abdelazim Ahmed Mohamed, Abdalla, Mahmood Ameen, Salama, Suzy Munir, Al Wajeeh, Nahla Saeed
Format: Article
Published: University of Ljubljana 2021
Subjects:
QK Botany
RV Botanic, Thomsonian, and eclectic medicine
Online Access:http://eprints.um.edu.my/35522/
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spelling my.um.eprints.355222023-10-17T03:01:48Z http://eprints.um.edu.my/35522/ Antioxidant activity and acute toxicity of two Lagenaria siceraria (Molina) Standl. Varieties from Sudan Antioksidacijska aktivnost in akutna toksičnost dveh sort vodnjače (Lagenaria siceraria (Molina) Standl.) Iz Sudana Mariod, Abdalbasit Adam Mustafa, Makarim Mutasim Mohamed Nour, Abdelazim Ahmed Mohamed Abdalla, Mahmood Ameen Salama, Suzy Munir Al Wajeeh, Nahla Saeed QK Botany RV Botanic, Thomsonian, and eclectic medicine The present study was conducted to evaluate the antioxidant capacity and acute toxicity of the methanol extract of two Lagenaria siceraria (Molina) Standl. varieties of dried seeds, Sweet gourd Water Jug (WJ) and bitter gourd Basket Ball (BB). The seed extracts were tested for their total phenolic contents (TPC), total flavonoid contents (TFC), ferric reducing antioxidant power (FRAP) and scavenging activity to the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). Both dried seed extracts were then tested for acute toxicity at doses 2 and 5 g kg-1each. Sixty female and male rats were assigned into five groups per sex. Four groups were given low and high doses of each dried seed extract and the fifth group was given 10 Tween 20 as a control. Kidneys and livers of all rats were assessed for biochemistry and histopathology. The seed extract of WJ revealed higher TPC, FRAP and DPPH activities compared to BB seeds, while TFC results were reversed. Toxicologically, no toxicity signs were recorded in animals. Biochemistry results were within the normal ranges with a slight increase in bilirubin and Alanine aminotransferase (ALT), and histology of kidneys and livers showed normal architecture. In conclusion, WJ and BB dried seed extracts exhibited high antioxidant activity suggesting promising therapeutic regimen against oxidative stress. © 2020 University of Ljubljana. All rights reserved. University of Ljubljana 2021 Article PeerReviewed Mariod, Abdalbasit Adam and Mustafa, Makarim Mutasim Mohamed and Nour, Abdelazim Ahmed Mohamed and Abdalla, Mahmood Ameen and Salama, Suzy Munir and Al Wajeeh, Nahla Saeed (2021) Antioxidant activity and acute toxicity of two Lagenaria siceraria (Molina) Standl. Varieties from Sudan Antioksidacijska aktivnost in akutna toksičnost dveh sort vodnjače (Lagenaria siceraria (Molina) Standl.) Iz Sudana. Acta agriculturae Slovenica, 116 (2). pp. 261-271. ISSN 1581-9175, DOI https://doi.org/10.14720/aas.2020.116.2.1031 <https://doi.org/10.14720/aas.2020.116.2.1031>. 10.14720/aas.2020.116.2.1031
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QK Botany
RV Botanic, Thomsonian, and eclectic medicine
spellingShingle QK Botany
RV Botanic, Thomsonian, and eclectic medicine
Mariod, Abdalbasit Adam
Mustafa, Makarim Mutasim Mohamed
Nour, Abdelazim Ahmed Mohamed
Abdalla, Mahmood Ameen
Salama, Suzy Munir
Al Wajeeh, Nahla Saeed
Antioxidant activity and acute toxicity of two Lagenaria siceraria (Molina) Standl. Varieties from Sudan Antioksidacijska aktivnost in akutna toksičnost dveh sort vodnjače (Lagenaria siceraria (Molina) Standl.) Iz Sudana
description The present study was conducted to evaluate the antioxidant capacity and acute toxicity of the methanol extract of two Lagenaria siceraria (Molina) Standl. varieties of dried seeds, Sweet gourd Water Jug (WJ) and bitter gourd Basket Ball (BB). The seed extracts were tested for their total phenolic contents (TPC), total flavonoid contents (TFC), ferric reducing antioxidant power (FRAP) and scavenging activity to the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). Both dried seed extracts were then tested for acute toxicity at doses 2 and 5 g kg-1each. Sixty female and male rats were assigned into five groups per sex. Four groups were given low and high doses of each dried seed extract and the fifth group was given 10 Tween 20 as a control. Kidneys and livers of all rats were assessed for biochemistry and histopathology. The seed extract of WJ revealed higher TPC, FRAP and DPPH activities compared to BB seeds, while TFC results were reversed. Toxicologically, no toxicity signs were recorded in animals. Biochemistry results were within the normal ranges with a slight increase in bilirubin and Alanine aminotransferase (ALT), and histology of kidneys and livers showed normal architecture. In conclusion, WJ and BB dried seed extracts exhibited high antioxidant activity suggesting promising therapeutic regimen against oxidative stress. © 2020 University of Ljubljana. All rights reserved.
format Article
author Mariod, Abdalbasit Adam
Mustafa, Makarim Mutasim Mohamed
Nour, Abdelazim Ahmed Mohamed
Abdalla, Mahmood Ameen
Salama, Suzy Munir
Al Wajeeh, Nahla Saeed
author_facet Mariod, Abdalbasit Adam
Mustafa, Makarim Mutasim Mohamed
Nour, Abdelazim Ahmed Mohamed
Abdalla, Mahmood Ameen
Salama, Suzy Munir
Al Wajeeh, Nahla Saeed
author_sort Mariod, Abdalbasit Adam
title Antioxidant activity and acute toxicity of two Lagenaria siceraria (Molina) Standl. Varieties from Sudan Antioksidacijska aktivnost in akutna toksičnost dveh sort vodnjače (Lagenaria siceraria (Molina) Standl.) Iz Sudana
title_short Antioxidant activity and acute toxicity of two Lagenaria siceraria (Molina) Standl. Varieties from Sudan Antioksidacijska aktivnost in akutna toksičnost dveh sort vodnjače (Lagenaria siceraria (Molina) Standl.) Iz Sudana
title_full Antioxidant activity and acute toxicity of two Lagenaria siceraria (Molina) Standl. Varieties from Sudan Antioksidacijska aktivnost in akutna toksičnost dveh sort vodnjače (Lagenaria siceraria (Molina) Standl.) Iz Sudana
title_fullStr Antioxidant activity and acute toxicity of two Lagenaria siceraria (Molina) Standl. Varieties from Sudan Antioksidacijska aktivnost in akutna toksičnost dveh sort vodnjače (Lagenaria siceraria (Molina) Standl.) Iz Sudana
title_full_unstemmed Antioxidant activity and acute toxicity of two Lagenaria siceraria (Molina) Standl. Varieties from Sudan Antioksidacijska aktivnost in akutna toksičnost dveh sort vodnjače (Lagenaria siceraria (Molina) Standl.) Iz Sudana
title_sort antioxidant activity and acute toxicity of two lagenaria siceraria (molina) standl. varieties from sudan antioksidacijska aktivnost in akutna toksičnost dveh sort vodnjače (lagenaria siceraria (molina) standl.) iz sudana
publisher University of Ljubljana
publishDate 2021
url http://eprints.um.edu.my/35522/
_version_ 1781704478772166656
score 13.240574

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