A nanotechnological approach for enhancing the topical drug delivery by newly developed liquid crystal formulations
Transdermal drug administration is a great substitute to oral medication administration. Inadequate penetration of active pharmaceuticals via the skin, on the other hand, is a common phenomenon. As a result, we investigated the ability of liquid crystal (LC) topical formulations to improve skin pene...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Published: |
2021
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/35497/ |
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| Summary: | Transdermal drug administration is a great substitute to oral medication administration. Inadequate penetration of active pharmaceuticals via the skin, on the other hand, is a common phenomenon. As a result, we investigated the ability of liquid crystal (LC) topical formulations to improve skin penetration in the current study. LC-forming lipids are a significant class of biocompatible amphiphiles with applications in cosmetic, dietary, and medicinal technologies. Just a few experiments have looked into how the concentration of LC-forming lipids affects the ability of drugs to reach the skin following topical application. We initially prepared LC formulations of p-aminobenzoic acid (PABA) as a hydrophilic drug mode (The homogeneity and viscosity of the prepared formulations is determined). Additionally, we used a Zetasizer to determine the zeta potential and particle size of LC formulations. The dialysis procedure was used to determine the liberation of drugs from LC formulations. In-vitro skin penetration tests were conducted to decide if LC formulations could increase skin penetration and concentration. By understanding the influence of the LC-forming lipid concentration used in the LC preparation, researchers might establish LC formulation methods that increase drug skin penetration. © 2021, Dr. Yashwant Research Labs Pvt. Ltd.. All rights reserved. |
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