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Aphrodisiac potential of Polyalthia bullata (Tongkat Ali) in fowl

Objective: To study the aphrodisiac potential of Polyalthia (P.) bullata in fowl. Methods: In this study, testosterone, as an indicator of the aphrodisiac potential of P. bullata, was investigated for its release from TM3 Leydig cells grown in vitro and in 4 fowls given capsules containing P. bullat...

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Main Authors: Vejayan, Jaya, Yahya, Yasmin, Chakravarthi, Srikumar, Ibrahim, Halijah, Yun, Aida
Format: Article
Published: 2021
Subjects:
QK Botany
RV Botanic, Thomsonian, and eclectic medicine
Online Access:http://eprints.um.edu.my/35478/
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spelling my.um.eprints.354782023-10-09T10:40:20Z http://eprints.um.edu.my/35478/ Aphrodisiac potential of Polyalthia bullata (Tongkat Ali) in fowl Vejayan, Jaya Yahya, Yasmin Chakravarthi, Srikumar Ibrahim, Halijah Yun, Aida QK Botany RV Botanic, Thomsonian, and eclectic medicine Objective: To study the aphrodisiac potential of Polyalthia (P.) bullata in fowl. Methods: In this study, testosterone, as an indicator of the aphrodisiac potential of P. bullata, was investigated for its release from TM3 Leydig cells grown in vitro and in 4 fowls given capsules containing P. bullata at a dose of 10 mg in each capsule twice a day, for 50 days. In the latter in vivo evaluation, mating behaviours were additionally determined after the treated fowls were released to the individual hens, and their testes and liver were dissected for histological examinations. Blood drawn from the fowls was assessed for any changes in diagnostic parameters. Results: In the in vitro test (TM3 Leydig cells), P. bullata was able to increase testosterone to 0.48 nmol/L within 72 h of incubation, compared to the untreated control with only 0.18 nmol/L, i.e., an increase of 170. In the in vivo test, outcomes in the fowls dosed with P. bullata showed similar positive elevations of testosterone to (9.72±1.10) nmol/L in comparison to the controls that showed a level of only (4.05±0.84) nmol/L. Total frequencies of mating behaviours were observed (wing flapping, body shakes, crowing and beak pecking) to be 23 counts for the test compared to only 15 for the control fowls. Histological examination of the male reproductive organs provided evidence of testosterone boosting based on an observable increase in the activity at the seminiferous tubules of testis tissues without any damaging effects, compared to the controls. In the nine diagnostic blood parameters assessed, including alanine aminotransferase, aspartate aminotransferase, and gamma glutamyltransferase, none was remarkably elevated compared to the controls. The histological changes in the liver were not severe and mainly consisted of only localized moderate but recoverable obstructions and swellings of the vessels and tubules. Conclusions: P. bullata is able to boost testosterone both in vitro and in vivo, with no acute toxicities. © 2021 Medknow. 2021 Article PeerReviewed Vejayan, Jaya and Yahya, Yasmin and Chakravarthi, Srikumar and Ibrahim, Halijah and Yun, Aida (2021) Aphrodisiac potential of Polyalthia bullata (Tongkat Ali) in fowl. Asian Pacific Journal of Reproduction, 10 (2). pp. 75-81. ISSN 23050500, DOI https://doi.org/10.4103/2305-0500.311615 <https://doi.org/10.4103/2305-0500.311615>. 10.4103/2305-0500.311615
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QK Botany
RV Botanic, Thomsonian, and eclectic medicine
spellingShingle QK Botany
RV Botanic, Thomsonian, and eclectic medicine
Vejayan, Jaya
Yahya, Yasmin
Chakravarthi, Srikumar
Ibrahim, Halijah
Yun, Aida
Aphrodisiac potential of Polyalthia bullata (Tongkat Ali) in fowl
description Objective: To study the aphrodisiac potential of Polyalthia (P.) bullata in fowl. Methods: In this study, testosterone, as an indicator of the aphrodisiac potential of P. bullata, was investigated for its release from TM3 Leydig cells grown in vitro and in 4 fowls given capsules containing P. bullata at a dose of 10 mg in each capsule twice a day, for 50 days. In the latter in vivo evaluation, mating behaviours were additionally determined after the treated fowls were released to the individual hens, and their testes and liver were dissected for histological examinations. Blood drawn from the fowls was assessed for any changes in diagnostic parameters. Results: In the in vitro test (TM3 Leydig cells), P. bullata was able to increase testosterone to 0.48 nmol/L within 72 h of incubation, compared to the untreated control with only 0.18 nmol/L, i.e., an increase of 170. In the in vivo test, outcomes in the fowls dosed with P. bullata showed similar positive elevations of testosterone to (9.72±1.10) nmol/L in comparison to the controls that showed a level of only (4.05±0.84) nmol/L. Total frequencies of mating behaviours were observed (wing flapping, body shakes, crowing and beak pecking) to be 23 counts for the test compared to only 15 for the control fowls. Histological examination of the male reproductive organs provided evidence of testosterone boosting based on an observable increase in the activity at the seminiferous tubules of testis tissues without any damaging effects, compared to the controls. In the nine diagnostic blood parameters assessed, including alanine aminotransferase, aspartate aminotransferase, and gamma glutamyltransferase, none was remarkably elevated compared to the controls. The histological changes in the liver were not severe and mainly consisted of only localized moderate but recoverable obstructions and swellings of the vessels and tubules. Conclusions: P. bullata is able to boost testosterone both in vitro and in vivo, with no acute toxicities. © 2021 Medknow.
format Article
author Vejayan, Jaya
Yahya, Yasmin
Chakravarthi, Srikumar
Ibrahim, Halijah
Yun, Aida
author_facet Vejayan, Jaya
Yahya, Yasmin
Chakravarthi, Srikumar
Ibrahim, Halijah
Yun, Aida
author_sort Vejayan, Jaya
title Aphrodisiac potential of Polyalthia bullata (Tongkat Ali) in fowl
title_short Aphrodisiac potential of Polyalthia bullata (Tongkat Ali) in fowl
title_full Aphrodisiac potential of Polyalthia bullata (Tongkat Ali) in fowl
title_fullStr Aphrodisiac potential of Polyalthia bullata (Tongkat Ali) in fowl
title_full_unstemmed Aphrodisiac potential of Polyalthia bullata (Tongkat Ali) in fowl
title_sort aphrodisiac potential of polyalthia bullata (tongkat ali) in fowl
publishDate 2021
url http://eprints.um.edu.my/35478/
_version_ 1781704473312231424
score 13.211869

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