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The utility of n-terminal pro-brain natriuretic peptide as an adjunct diagnostic tool for acute heart failure in acute dyspneic patients coming to the emergency department: A retrospective review of our early experience

Acute dyspnea is one of the prevalent reasons for admission to the emergency department. The use of N-terminal pro-B-type natriuretic peptide (NT-proBNP) as an adjunct for assessing acute dyspnea is not a common practice in many public hospitals in Malaysia. This retrospective review is part of our...

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Main Authors: Rajah, Rathika, Yee, Lim Kuan, Hau, Ng Boon, Soo, Chun Ian
Format: Article
Published: Penerbit Universiti Sains Malaysia 2021
Subjects:
R Medicine (General)
Online Access:http://eprints.um.edu.my/35186/
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spelling my.um.eprints.351862022-09-01T07:47:05Z http://eprints.um.edu.my/35186/ The utility of n-terminal pro-brain natriuretic peptide as an adjunct diagnostic tool for acute heart failure in acute dyspneic patients coming to the emergency department: A retrospective review of our early experience Rajah, Rathika Yee, Lim Kuan Hau, Ng Boon Soo, Chun Ian R Medicine (General) Acute dyspnea is one of the prevalent reasons for admission to the emergency department. The use of N-terminal pro-B-type natriuretic peptide (NT-proBNP) as an adjunct for assessing acute dyspnea is not a common practice in many public hospitals in Malaysia. This retrospective review is part of our clinical audit to determine the utility of NT-proBNP as an adjunct to non-standardised clinical evaluation in identifying acute heart failure (HF) in patients with persistent dyspnea (24 h) post-admission. In this cohort of 30 patients with acute dyspnea, NT-proBNP was positive in zo patients (87%) with acute HF. Three patients (13%) who were treated for septic shock recorded a NT-proBNP false-positive. NT-proBNP demonstrated an overall sensitivity of 90%, a specificity of 70%, a positive predictive value of 85.7% and a negative predictive value of 77.8% in identifying acute HF. These results reinforce that age-stratified NT-proBNP cut-off values are useful for ruling-in or -out acute HF. Thus, NT-proBNP should be considered a crucial point of care, testing to deafer the conundrum of acute dyspneic patients. Penerbit Universiti Sains Malaysia 2021 Article PeerReviewed Rajah, Rathika and Yee, Lim Kuan and Hau, Ng Boon and Soo, Chun Ian (2021) The utility of n-terminal pro-brain natriuretic peptide as an adjunct diagnostic tool for acute heart failure in acute dyspneic patients coming to the emergency department: A retrospective review of our early experience. Malaysian Journal of Medical Sciences, 28 (4). pp. 146-152. ISSN 1394-195X, DOI https://doi.org/10.21315/mjms2021.28.4.15 <https://doi.org/10.21315/mjms2021.28.4.15>. 10.21315/mjms2021.28.4.15
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine (General)
spellingShingle R Medicine (General)
Rajah, Rathika
Yee, Lim Kuan
Hau, Ng Boon
Soo, Chun Ian
The utility of n-terminal pro-brain natriuretic peptide as an adjunct diagnostic tool for acute heart failure in acute dyspneic patients coming to the emergency department: A retrospective review of our early experience
description Acute dyspnea is one of the prevalent reasons for admission to the emergency department. The use of N-terminal pro-B-type natriuretic peptide (NT-proBNP) as an adjunct for assessing acute dyspnea is not a common practice in many public hospitals in Malaysia. This retrospective review is part of our clinical audit to determine the utility of NT-proBNP as an adjunct to non-standardised clinical evaluation in identifying acute heart failure (HF) in patients with persistent dyspnea (24 h) post-admission. In this cohort of 30 patients with acute dyspnea, NT-proBNP was positive in zo patients (87%) with acute HF. Three patients (13%) who were treated for septic shock recorded a NT-proBNP false-positive. NT-proBNP demonstrated an overall sensitivity of 90%, a specificity of 70%, a positive predictive value of 85.7% and a negative predictive value of 77.8% in identifying acute HF. These results reinforce that age-stratified NT-proBNP cut-off values are useful for ruling-in or -out acute HF. Thus, NT-proBNP should be considered a crucial point of care, testing to deafer the conundrum of acute dyspneic patients.
format Article
author Rajah, Rathika
Yee, Lim Kuan
Hau, Ng Boon
Soo, Chun Ian
author_facet Rajah, Rathika
Yee, Lim Kuan
Hau, Ng Boon
Soo, Chun Ian
author_sort Rajah, Rathika
title The utility of n-terminal pro-brain natriuretic peptide as an adjunct diagnostic tool for acute heart failure in acute dyspneic patients coming to the emergency department: A retrospective review of our early experience
title_short The utility of n-terminal pro-brain natriuretic peptide as an adjunct diagnostic tool for acute heart failure in acute dyspneic patients coming to the emergency department: A retrospective review of our early experience
title_full The utility of n-terminal pro-brain natriuretic peptide as an adjunct diagnostic tool for acute heart failure in acute dyspneic patients coming to the emergency department: A retrospective review of our early experience
title_fullStr The utility of n-terminal pro-brain natriuretic peptide as an adjunct diagnostic tool for acute heart failure in acute dyspneic patients coming to the emergency department: A retrospective review of our early experience
title_full_unstemmed The utility of n-terminal pro-brain natriuretic peptide as an adjunct diagnostic tool for acute heart failure in acute dyspneic patients coming to the emergency department: A retrospective review of our early experience
title_sort utility of n-terminal pro-brain natriuretic peptide as an adjunct diagnostic tool for acute heart failure in acute dyspneic patients coming to the emergency department: a retrospective review of our early experience
publisher Penerbit Universiti Sains Malaysia
publishDate 2021
url http://eprints.um.edu.my/35186/
_version_ 1744649222438780928
score 13.211869

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