Multiyear prospective cohort study to evaluate the risk potential of MERS-CoV infection among Malaysian hajj pilgrims (MERCURIAL): A study protocol
Middle East respiratory syndrome (MERS) is a viral respiratory infection caused by the MERS-CoV. MERS was first reported in the Kingdom of Saudi Arabia in 2012. Every year, the Hajj pilgrimage to Mecca attracts more than two million pilgrims from 184 countries, making it one of the largest annual re...
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2021
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my.um.eprints.346972022-09-19T03:01:01Z http://eprints.um.edu.my/34697/ Multiyear prospective cohort study to evaluate the risk potential of MERS-CoV infection among Malaysian hajj pilgrims (MERCURIAL): A study protocol Johari, Mohd Iskandar Jefree Hontz, Robert D. Pike, Brian L. Husain, Tupur Chong, Chee-Kheong Rusli, Norhayati Sulaiman, Lokman-Hakim Verasahib, Khebir Zain, Rozainanee Mohd Azman, Adzzie-Shazleen Khor, Chee Sieng Nor'e, Siti-Sarah Tiong, Vunjia Lee, Hai Yen Teoh, Boon-Teong Sam, Sing Sin Khoo, Jing-Jing Abd Jamil, Juraina Loong, Shih-Keng Yaacob, Che Norainon Mahfodz, Nur-Hidayana Azizan, Noor Syahida Seri, Nurul Asma Anati Che Mat Mohd-Rahim, Nurul-Farhana Hassan, Habibi Yahaya, Hasmawati Garcia-Rivera, Jose A. AbuBakar, Sazaly QR Microbiology R Medicine RA Public aspects of medicine RB Pathology Theories of disease. Etiology. Pathogenesis Middle East respiratory syndrome (MERS) is a viral respiratory infection caused by the MERS-CoV. MERS was first reported in the Kingdom of Saudi Arabia in 2012. Every year, the Hajj pilgrimage to Mecca attracts more than two million pilgrims from 184 countries, making it one of the largest annual religious mass gatherings (MGs) worldwide. MGs in confined areas with a high number of pilgrims' movements worldwide continues to elicit significant global public health concerns. MERCURIAL was designed by adopting a seroconversion surveillance approach to provide multiyear evidence of MG-associated MERS-CoV seroconversion among the Malaysian Hajj pilgrims. Methods and analysis MERCURIAL is an ongoing multiyear prospective cohort study. Every year, for the next 5 years, a cohort of 1000 Hajj pilgrims was enrolled beginning in the 2016 Hajj pilgrimage season. Pre-Hajj and post-Hajj serum samples were obtained and serologically analysed for evidence of MERS-CoV seroconversion. Sociodemographic data, underlying medical conditions, symptoms experienced during Hajj pilgrimage, and exposure to camel and untreated camel products were recorded using structured pre-Hajj and post-Hajj questionnaires. The possible risk factors associated with the seroconversion data were analysed using univariate and multivariate logistic regression. The primary outcome of this study is to better enhance our understanding of the potential threat of MERS-CoV spreading through MG beyond the Middle East. Ethics and dissemination This study has obtained ethical approval from the Medical Research and Ethics Committee (MREC), Ministry of Health Malaysia. Results from the study will be submitted for publication in peer-reviewed journals and presented in conferences and scientific meetings. BMJ Publishing Group 2021 Article PeerReviewed Johari, Mohd Iskandar Jefree and Hontz, Robert D. and Pike, Brian L. and Husain, Tupur and Chong, Chee-Kheong and Rusli, Norhayati and Sulaiman, Lokman-Hakim and Verasahib, Khebir and Zain, Rozainanee Mohd and Azman, Adzzie-Shazleen and Khor, Chee Sieng and Nor'e, Siti-Sarah and Tiong, Vunjia and Lee, Hai Yen and Teoh, Boon-Teong and Sam, Sing Sin and Khoo, Jing-Jing and Abd Jamil, Juraina and Loong, Shih-Keng and Yaacob, Che Norainon and Mahfodz, Nur-Hidayana and Azizan, Noor Syahida and Seri, Nurul Asma Anati Che Mat and Mohd-Rahim, Nurul-Farhana and Hassan, Habibi and Yahaya, Hasmawati and Garcia-Rivera, Jose A. and AbuBakar, Sazaly (2021) Multiyear prospective cohort study to evaluate the risk potential of MERS-CoV infection among Malaysian hajj pilgrims (MERCURIAL): A study protocol. BMJ Open, 11 (8). ISSN 2044-6055, DOI https://doi.org/10.1136/bmjopen-2021-050901 <https://doi.org/10.1136/bmjopen-2021-050901>. 10.1136/bmjopen-2021-050901 |
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QR Microbiology R Medicine RA Public aspects of medicine RB Pathology Theories of disease. Etiology. Pathogenesis |
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QR Microbiology R Medicine RA Public aspects of medicine RB Pathology Theories of disease. Etiology. Pathogenesis Johari, Mohd Iskandar Jefree Hontz, Robert D. Pike, Brian L. Husain, Tupur Chong, Chee-Kheong Rusli, Norhayati Sulaiman, Lokman-Hakim Verasahib, Khebir Zain, Rozainanee Mohd Azman, Adzzie-Shazleen Khor, Chee Sieng Nor'e, Siti-Sarah Tiong, Vunjia Lee, Hai Yen Teoh, Boon-Teong Sam, Sing Sin Khoo, Jing-Jing Abd Jamil, Juraina Loong, Shih-Keng Yaacob, Che Norainon Mahfodz, Nur-Hidayana Azizan, Noor Syahida Seri, Nurul Asma Anati Che Mat Mohd-Rahim, Nurul-Farhana Hassan, Habibi Yahaya, Hasmawati Garcia-Rivera, Jose A. AbuBakar, Sazaly Multiyear prospective cohort study to evaluate the risk potential of MERS-CoV infection among Malaysian hajj pilgrims (MERCURIAL): A study protocol |
| description |
Middle East respiratory syndrome (MERS) is a viral respiratory infection caused by the MERS-CoV. MERS was first reported in the Kingdom of Saudi Arabia in 2012. Every year, the Hajj pilgrimage to Mecca attracts more than two million pilgrims from 184 countries, making it one of the largest annual religious mass gatherings (MGs) worldwide. MGs in confined areas with a high number of pilgrims' movements worldwide continues to elicit significant global public health concerns. MERCURIAL was designed by adopting a seroconversion surveillance approach to provide multiyear evidence of MG-associated MERS-CoV seroconversion among the Malaysian Hajj pilgrims. Methods and analysis MERCURIAL is an ongoing multiyear prospective cohort study. Every year, for the next 5 years, a cohort of 1000 Hajj pilgrims was enrolled beginning in the 2016 Hajj pilgrimage season. Pre-Hajj and post-Hajj serum samples were obtained and serologically analysed for evidence of MERS-CoV seroconversion. Sociodemographic data, underlying medical conditions, symptoms experienced during Hajj pilgrimage, and exposure to camel and untreated camel products were recorded using structured pre-Hajj and post-Hajj questionnaires. The possible risk factors associated with the seroconversion data were analysed using univariate and multivariate logistic regression. The primary outcome of this study is to better enhance our understanding of the potential threat of MERS-CoV spreading through MG beyond the Middle East. Ethics and dissemination This study has obtained ethical approval from the Medical Research and Ethics Committee (MREC), Ministry of Health Malaysia. Results from the study will be submitted for publication in peer-reviewed journals and presented in conferences and scientific meetings. |
| format |
Article |
| author |
Johari, Mohd Iskandar Jefree Hontz, Robert D. Pike, Brian L. Husain, Tupur Chong, Chee-Kheong Rusli, Norhayati Sulaiman, Lokman-Hakim Verasahib, Khebir Zain, Rozainanee Mohd Azman, Adzzie-Shazleen Khor, Chee Sieng Nor'e, Siti-Sarah Tiong, Vunjia Lee, Hai Yen Teoh, Boon-Teong Sam, Sing Sin Khoo, Jing-Jing Abd Jamil, Juraina Loong, Shih-Keng Yaacob, Che Norainon Mahfodz, Nur-Hidayana Azizan, Noor Syahida Seri, Nurul Asma Anati Che Mat Mohd-Rahim, Nurul-Farhana Hassan, Habibi Yahaya, Hasmawati Garcia-Rivera, Jose A. AbuBakar, Sazaly |
| author_facet |
Johari, Mohd Iskandar Jefree Hontz, Robert D. Pike, Brian L. Husain, Tupur Chong, Chee-Kheong Rusli, Norhayati Sulaiman, Lokman-Hakim Verasahib, Khebir Zain, Rozainanee Mohd Azman, Adzzie-Shazleen Khor, Chee Sieng Nor'e, Siti-Sarah Tiong, Vunjia Lee, Hai Yen Teoh, Boon-Teong Sam, Sing Sin Khoo, Jing-Jing Abd Jamil, Juraina Loong, Shih-Keng Yaacob, Che Norainon Mahfodz, Nur-Hidayana Azizan, Noor Syahida Seri, Nurul Asma Anati Che Mat Mohd-Rahim, Nurul-Farhana Hassan, Habibi Yahaya, Hasmawati Garcia-Rivera, Jose A. AbuBakar, Sazaly |
| author_sort |
Johari, Mohd Iskandar Jefree |
| title |
Multiyear prospective cohort study to evaluate the risk potential of MERS-CoV infection among Malaysian hajj pilgrims (MERCURIAL): A study protocol |
| title_short |
Multiyear prospective cohort study to evaluate the risk potential of MERS-CoV infection among Malaysian hajj pilgrims (MERCURIAL): A study protocol |
| title_full |
Multiyear prospective cohort study to evaluate the risk potential of MERS-CoV infection among Malaysian hajj pilgrims (MERCURIAL): A study protocol |
| title_fullStr |
Multiyear prospective cohort study to evaluate the risk potential of MERS-CoV infection among Malaysian hajj pilgrims (MERCURIAL): A study protocol |
| title_full_unstemmed |
Multiyear prospective cohort study to evaluate the risk potential of MERS-CoV infection among Malaysian hajj pilgrims (MERCURIAL): A study protocol |
| title_sort |
multiyear prospective cohort study to evaluate the risk potential of mers-cov infection among malaysian hajj pilgrims (mercurial): a study protocol |
| publisher |
BMJ Publishing Group |
| publishDate |
2021 |
| url |
http://eprints.um.edu.my/34697/ |
| _version_ |
1744649195346722816 |
| score |
13.211869 |