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The intellicage system: A review of its utility as a novel behavioral platform for a rodent model of substance use disorder

The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of the behavioral and molecular mechanisms underlying substance abuse and addiction. Here, we review a novel and comprehensive behavioral platform to characterize addiction-like traits i...

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Main Authors: Iman, Ismail Nurul, Yusof, Nurul Aiman Mohd, Talib, Ummi Nasrah, Ahmad, Nur Aimi Zawami, Norazit, Anwar, Kumar, Jaya, Mehat, Muhammad Zulfadli, Jayabalan, Nanthini, Muthuraju, Sangu, Stefaniuk, Marzena, Kaczmarek, Leszek, Muzaimi, Mustapha
Format: Article
Published: Frontiers Media SA 2021
Subjects:
R Medicine (General)
Online Access:http://eprints.um.edu.my/34521/
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spelling my.um.eprints.345212022-06-01T04:41:31Z http://eprints.um.edu.my/34521/ The intellicage system: A review of its utility as a novel behavioral platform for a rodent model of substance use disorder Iman, Ismail Nurul Yusof, Nurul Aiman Mohd Talib, Ummi Nasrah Ahmad, Nur Aimi Zawami Norazit, Anwar Kumar, Jaya Mehat, Muhammad Zulfadli Jayabalan, Nanthini Muthuraju, Sangu Stefaniuk, Marzena Kaczmarek, Leszek Muzaimi, Mustapha R Medicine (General) The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of the behavioral and molecular mechanisms underlying substance abuse and addiction. Here, we review a novel and comprehensive behavioral platform to characterize addiction-like traits in rodents using a fully automated learning system, the IntelliCage. This system simultaneously captures the basic behavioral navigation, reward preference, and aversion, as well as the multi-dimensional complex behaviors and cognitive functions of group-housed rodents. It can reliably capture and track locomotor and cognitive pattern alterations associated with the development of substance addiction. Thus, the IntelliCage learning system offers a potentially efficient, flexible, and sensitive tool for the high-throughput screening of the rodent SUD model. Frontiers Media SA 2021-06-04 Article PeerReviewed Iman, Ismail Nurul and Yusof, Nurul Aiman Mohd and Talib, Ummi Nasrah and Ahmad, Nur Aimi Zawami and Norazit, Anwar and Kumar, Jaya and Mehat, Muhammad Zulfadli and Jayabalan, Nanthini and Muthuraju, Sangu and Stefaniuk, Marzena and Kaczmarek, Leszek and Muzaimi, Mustapha (2021) The intellicage system: A review of its utility as a novel behavioral platform for a rodent model of substance use disorder. Frontiers In Behavioral Neuroscience, 15. ISSN 1662-5153, DOI https://doi.org/10.3389/fnbeh.2021.683780 <https://doi.org/10.3389/fnbeh.2021.683780>. 10.3389/fnbeh.2021.683780
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine (General)
spellingShingle R Medicine (General)
Iman, Ismail Nurul
Yusof, Nurul Aiman Mohd
Talib, Ummi Nasrah
Ahmad, Nur Aimi Zawami
Norazit, Anwar
Kumar, Jaya
Mehat, Muhammad Zulfadli
Jayabalan, Nanthini
Muthuraju, Sangu
Stefaniuk, Marzena
Kaczmarek, Leszek
Muzaimi, Mustapha
The intellicage system: A review of its utility as a novel behavioral platform for a rodent model of substance use disorder
description The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of the behavioral and molecular mechanisms underlying substance abuse and addiction. Here, we review a novel and comprehensive behavioral platform to characterize addiction-like traits in rodents using a fully automated learning system, the IntelliCage. This system simultaneously captures the basic behavioral navigation, reward preference, and aversion, as well as the multi-dimensional complex behaviors and cognitive functions of group-housed rodents. It can reliably capture and track locomotor and cognitive pattern alterations associated with the development of substance addiction. Thus, the IntelliCage learning system offers a potentially efficient, flexible, and sensitive tool for the high-throughput screening of the rodent SUD model.
format Article
author Iman, Ismail Nurul
Yusof, Nurul Aiman Mohd
Talib, Ummi Nasrah
Ahmad, Nur Aimi Zawami
Norazit, Anwar
Kumar, Jaya
Mehat, Muhammad Zulfadli
Jayabalan, Nanthini
Muthuraju, Sangu
Stefaniuk, Marzena
Kaczmarek, Leszek
Muzaimi, Mustapha
author_facet Iman, Ismail Nurul
Yusof, Nurul Aiman Mohd
Talib, Ummi Nasrah
Ahmad, Nur Aimi Zawami
Norazit, Anwar
Kumar, Jaya
Mehat, Muhammad Zulfadli
Jayabalan, Nanthini
Muthuraju, Sangu
Stefaniuk, Marzena
Kaczmarek, Leszek
Muzaimi, Mustapha
author_sort Iman, Ismail Nurul
title The intellicage system: A review of its utility as a novel behavioral platform for a rodent model of substance use disorder
title_short The intellicage system: A review of its utility as a novel behavioral platform for a rodent model of substance use disorder
title_full The intellicage system: A review of its utility as a novel behavioral platform for a rodent model of substance use disorder
title_fullStr The intellicage system: A review of its utility as a novel behavioral platform for a rodent model of substance use disorder
title_full_unstemmed The intellicage system: A review of its utility as a novel behavioral platform for a rodent model of substance use disorder
title_sort intellicage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder
publisher Frontiers Media SA
publishDate 2021
url http://eprints.um.edu.my/34521/
_version_ 1735409611615240192
score 13.211869

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