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Traumatic brain injury outcomes in 10 Asian pediatric ICUs: A pediatric acute and critical care medicine Asian network retrospective study

Traumatic brain injury remains an important cause of death and disability. We aim to report the epidemiology and management of moderate to severe traumatic brain injury in Asian PICUs and identify risk factors for mortality and poor functional outcomes. Design: A retrospective study of the Pediatric...

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Main Authors: Chong, Shu-Ling, Dang, Hongxing, Ming, Meixiu, Mahmood, Maznisah, Zheng, Charles Q. S., Gan, Chin Seng, Lee, Olive P. E., Ji, Jian, Chan, Lawrence C. N., Ong, Jacqueline S. M., Kurosawa, Hiroshi, Lee, Jan Hau, As, Pediat Acute Critical Care Med
Format: Article
Published: Lippincott Williams & Wilkins 2021
Subjects:
R Medicine
RC Internal medicine
RJ Pediatrics
Online Access:http://eprints.um.edu.my/34500/
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spelling my.um.eprints.345002022-09-14T06:37:35Z http://eprints.um.edu.my/34500/ Traumatic brain injury outcomes in 10 Asian pediatric ICUs: A pediatric acute and critical care medicine Asian network retrospective study Chong, Shu-Ling Dang, Hongxing Ming, Meixiu Mahmood, Maznisah Zheng, Charles Q. S. Gan, Chin Seng Lee, Olive P. E. Ji, Jian Chan, Lawrence C. N. Ong, Jacqueline S. M. Kurosawa, Hiroshi Lee, Jan Hau As, Pediat Acute Critical Care Med R Medicine RC Internal medicine RJ Pediatrics Traumatic brain injury remains an important cause of death and disability. We aim to report the epidemiology and management of moderate to severe traumatic brain injury in Asian PICUs and identify risk factors for mortality and poor functional outcomes. Design: A retrospective study of the Pediatric Acute and Critical Care Medicine Asian Network moderate to severe traumatic brain injury dataset collected between 2014 and 2017. Setting: Patients were from the participating PICUs of Pediatric Acute and Critical Care Medicine Asian Network. Patients: We included children less than 16 years old with a Glasgow Coma Scale less than or equal to 13. Interventions: None. Measurements and Main Results: We obtained data on patient demographics, injury circumstances, and PICU management. We performed a multivariate logistic regression predicting for mortality and poor functional outcomes. We analyzed 380 children with moderate to severe traumatic brain injury. Most injuries were a result of road traffic injuries (174 45.8%]) and falls (160 42.1%]). There were important differences in temperature control, use of antiepileptic drugs, and hyperosmolar agents between the sites. Fifty-six children died (14.7%), and 104 of 324 survivors (32.1%) had poor functional outcomes. Poor functional outcomes were associated with non-high-income sites (adjusted odds ratio, 1.90; 95% CI, 1.11-3.29), Glasgow Coma Scale less than 8 (adjusted odds ratio, 4.24; 95% CI, 2.44-7.63), involvement in a road traffic collision (adjusted odds ratio, 1.83; 95% CI, 1.04-3.26), and presence of child abuse (adjusted odds ratio, 2.75; 95% CI, 1.01-7.46). Conclusions: Poor functional outcomes are prevalent after pediatric traumatic brain injury in Asia. There is an urgent need for further research in these high-risk groups. Lippincott Williams & Wilkins 2021-04 Article PeerReviewed Chong, Shu-Ling and Dang, Hongxing and Ming, Meixiu and Mahmood, Maznisah and Zheng, Charles Q. S. and Gan, Chin Seng and Lee, Olive P. E. and Ji, Jian and Chan, Lawrence C. N. and Ong, Jacqueline S. M. and Kurosawa, Hiroshi and Lee, Jan Hau and As, Pediat Acute Critical Care Med (2021) Traumatic brain injury outcomes in 10 Asian pediatric ICUs: A pediatric acute and critical care medicine Asian network retrospective study. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 22 (4). pp. 401-411. ISSN 1529-7535, DOI https://doi.org/10.1097/PCC.0000000000002575 <https://doi.org/10.1097/PCC.0000000000002575>. 10.1097/PCC.0000000000002575
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
RC Internal medicine
RJ Pediatrics
spellingShingle R Medicine
RC Internal medicine
RJ Pediatrics
Chong, Shu-Ling
Dang, Hongxing
Ming, Meixiu
Mahmood, Maznisah
Zheng, Charles Q. S.
Gan, Chin Seng
Lee, Olive P. E.
Ji, Jian
Chan, Lawrence C. N.
Ong, Jacqueline S. M.
Kurosawa, Hiroshi
Lee, Jan Hau
As, Pediat Acute Critical Care Med
Traumatic brain injury outcomes in 10 Asian pediatric ICUs: A pediatric acute and critical care medicine Asian network retrospective study
description Traumatic brain injury remains an important cause of death and disability. We aim to report the epidemiology and management of moderate to severe traumatic brain injury in Asian PICUs and identify risk factors for mortality and poor functional outcomes. Design: A retrospective study of the Pediatric Acute and Critical Care Medicine Asian Network moderate to severe traumatic brain injury dataset collected between 2014 and 2017. Setting: Patients were from the participating PICUs of Pediatric Acute and Critical Care Medicine Asian Network. Patients: We included children less than 16 years old with a Glasgow Coma Scale less than or equal to 13. Interventions: None. Measurements and Main Results: We obtained data on patient demographics, injury circumstances, and PICU management. We performed a multivariate logistic regression predicting for mortality and poor functional outcomes. We analyzed 380 children with moderate to severe traumatic brain injury. Most injuries were a result of road traffic injuries (174 45.8%]) and falls (160 42.1%]). There were important differences in temperature control, use of antiepileptic drugs, and hyperosmolar agents between the sites. Fifty-six children died (14.7%), and 104 of 324 survivors (32.1%) had poor functional outcomes. Poor functional outcomes were associated with non-high-income sites (adjusted odds ratio, 1.90; 95% CI, 1.11-3.29), Glasgow Coma Scale less than 8 (adjusted odds ratio, 4.24; 95% CI, 2.44-7.63), involvement in a road traffic collision (adjusted odds ratio, 1.83; 95% CI, 1.04-3.26), and presence of child abuse (adjusted odds ratio, 2.75; 95% CI, 1.01-7.46). Conclusions: Poor functional outcomes are prevalent after pediatric traumatic brain injury in Asia. There is an urgent need for further research in these high-risk groups.
format Article
author Chong, Shu-Ling
Dang, Hongxing
Ming, Meixiu
Mahmood, Maznisah
Zheng, Charles Q. S.
Gan, Chin Seng
Lee, Olive P. E.
Ji, Jian
Chan, Lawrence C. N.
Ong, Jacqueline S. M.
Kurosawa, Hiroshi
Lee, Jan Hau
As, Pediat Acute Critical Care Med
author_facet Chong, Shu-Ling
Dang, Hongxing
Ming, Meixiu
Mahmood, Maznisah
Zheng, Charles Q. S.
Gan, Chin Seng
Lee, Olive P. E.
Ji, Jian
Chan, Lawrence C. N.
Ong, Jacqueline S. M.
Kurosawa, Hiroshi
Lee, Jan Hau
As, Pediat Acute Critical Care Med
author_sort Chong, Shu-Ling
title Traumatic brain injury outcomes in 10 Asian pediatric ICUs: A pediatric acute and critical care medicine Asian network retrospective study
title_short Traumatic brain injury outcomes in 10 Asian pediatric ICUs: A pediatric acute and critical care medicine Asian network retrospective study
title_full Traumatic brain injury outcomes in 10 Asian pediatric ICUs: A pediatric acute and critical care medicine Asian network retrospective study
title_fullStr Traumatic brain injury outcomes in 10 Asian pediatric ICUs: A pediatric acute and critical care medicine Asian network retrospective study
title_full_unstemmed Traumatic brain injury outcomes in 10 Asian pediatric ICUs: A pediatric acute and critical care medicine Asian network retrospective study
title_sort traumatic brain injury outcomes in 10 asian pediatric icus: a pediatric acute and critical care medicine asian network retrospective study
publisher Lippincott Williams & Wilkins
publishDate 2021
url http://eprints.um.edu.my/34500/
_version_ 1744649183223087104
score 13.211869

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