Effect of artocarpus-integer lectin on functional-activity of guinea-pig complement
The effect of Artocarpus integer lectin (lectin C) on the functional activity of guinea-pig complement was investigated. Purified and crude extract of lectin C from six cultivars of Artocarpus integer seeds were found to consume complement and thus decreased the complement-induced haemolytic activit...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Published: |
1994
|
| Subjects: | |
| Online Access: | http://eprints.um.edu.my/3449/ http://informahealthcare.com/doi/abs/10.3109/08820139409087796 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | The effect of Artocarpus integer lectin (lectin C) on the functional activity of guinea-pig complement was investigated. Purified and crude extract of lectin C from six cultivars of Artocarpus integer seeds were found to consume complement and thus decreased the complement-induced haemolytic activity of sensitized sheep erythrocytes. The change in the complement-mediated haemolytic activity was significantly decreased when incubation of the lectins was performed in the presence of melibiose. The reversal effect of the carbohydrate, which is a potent inhibitor of the lectin's binding to O-linked oligosaccharides of glycoprotein, demonstrate involvement of the lectins interaction with O-glycans of glycoproteins in the consumption of guinea-pig complement. |
|---|