Cover Image

Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers

MicroRNAs (miRNAs) are small regulatory molecules that are involved in posttranscriptional modifications. These noncoding RNAs are usually ferried by extracellular carriers such as exosomes or other protein and lipid carriers inside a range of body fluids including plasma and urine. Due to their abi...

Full description

Saved in:
Bibliographic Details
Main Authors: Tan, Paulina Pei Suu, Hall, Deborah, Chilian, William M., Chia, Yook Chin, Mohd Zain, Shamsul, Lim, Hooi Min, Kumar, Devaraj Navin, Ching, Siew Mooi, Low, Teck Yew, Noh, Mohd Fairulnizal Md, Pung, Yuh-Fen
Format: Article
Published: Amer Physiological Soc 2021
Subjects:
R Medicine (General)
Online Access:http://eprints.um.edu.my/34472/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.um.eprints.34472
record_format eprints
spelling my.um.eprints.344722022-05-31T07:58:52Z http://eprints.um.edu.my/34472/ Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers Tan, Paulina Pei Suu Hall, Deborah Chilian, William M. Chia, Yook Chin Mohd Zain, Shamsul Lim, Hooi Min Kumar, Devaraj Navin Ching, Siew Mooi Low, Teck Yew Noh, Mohd Fairulnizal Md Pung, Yuh-Fen R Medicine (General) MicroRNAs (miRNAs) are small regulatory molecules that are involved in posttranscriptional modifications. These noncoding RNAs are usually ferried by extracellular carriers such as exosomes or other protein and lipid carriers inside a range of body fluids including plasma and urine. Due to their ability to withstand harsh external conditions, exosomal miRNAs possess enormous potential as noninvasive disease biomarkers for, notably hypertension, whereby exosomal miRNAs have been implicated in its pathophysiological processes. More importantly, alterations in the microenvironment as a result of disease progression can induce active and selective loading of miRNAs into exosomes. In this paper, we first review the mechanisms of miRNA loading into exosomes, followed by the roles of exosomal miRNAs in the development of hypertension, and the potentials of exosomal miRNAs as biomarkers in comparison with other free circulating miRNAs. Finally, challenges and future research surrounding exosomal miRNAs will also be discussed. This review will aid in the understanding of noninvasive biomarkers for the early diagnosis of hypertension and for probing therapeutic efficacy. Amer Physiological Soc 2021-04 Article PeerReviewed Tan, Paulina Pei Suu and Hall, Deborah and Chilian, William M. and Chia, Yook Chin and Mohd Zain, Shamsul and Lim, Hooi Min and Kumar, Devaraj Navin and Ching, Siew Mooi and Low, Teck Yew and Noh, Mohd Fairulnizal Md and Pung, Yuh-Fen (2021) Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers. American Journal of Physiology-Heart and Circulatory Physiology, 320 (4). H1486-H1497. ISSN 0363-6135, DOI https://doi.org/10.1152/ajpheart.00888.2020 <https://doi.org/10.1152/ajpheart.00888.2020>. 10.1152/ajpheart.00888.2020
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine (General)
spellingShingle R Medicine (General)
Tan, Paulina Pei Suu
Hall, Deborah
Chilian, William M.
Chia, Yook Chin
Mohd Zain, Shamsul
Lim, Hooi Min
Kumar, Devaraj Navin
Ching, Siew Mooi
Low, Teck Yew
Noh, Mohd Fairulnizal Md
Pung, Yuh-Fen
Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers
description MicroRNAs (miRNAs) are small regulatory molecules that are involved in posttranscriptional modifications. These noncoding RNAs are usually ferried by extracellular carriers such as exosomes or other protein and lipid carriers inside a range of body fluids including plasma and urine. Due to their ability to withstand harsh external conditions, exosomal miRNAs possess enormous potential as noninvasive disease biomarkers for, notably hypertension, whereby exosomal miRNAs have been implicated in its pathophysiological processes. More importantly, alterations in the microenvironment as a result of disease progression can induce active and selective loading of miRNAs into exosomes. In this paper, we first review the mechanisms of miRNA loading into exosomes, followed by the roles of exosomal miRNAs in the development of hypertension, and the potentials of exosomal miRNAs as biomarkers in comparison with other free circulating miRNAs. Finally, challenges and future research surrounding exosomal miRNAs will also be discussed. This review will aid in the understanding of noninvasive biomarkers for the early diagnosis of hypertension and for probing therapeutic efficacy.
format Article
author Tan, Paulina Pei Suu
Hall, Deborah
Chilian, William M.
Chia, Yook Chin
Mohd Zain, Shamsul
Lim, Hooi Min
Kumar, Devaraj Navin
Ching, Siew Mooi
Low, Teck Yew
Noh, Mohd Fairulnizal Md
Pung, Yuh-Fen
author_facet Tan, Paulina Pei Suu
Hall, Deborah
Chilian, William M.
Chia, Yook Chin
Mohd Zain, Shamsul
Lim, Hooi Min
Kumar, Devaraj Navin
Ching, Siew Mooi
Low, Teck Yew
Noh, Mohd Fairulnizal Md
Pung, Yuh-Fen
author_sort Tan, Paulina Pei Suu
title Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers
title_short Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers
title_full Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers
title_fullStr Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers
title_full_unstemmed Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers
title_sort exosomal micrornas in the development of essential hypertension and its potential as biomarkers
publisher Amer Physiological Soc
publishDate 2021
url http://eprints.um.edu.my/34472/
_version_ 1735409608429666304
score 13.211869

Similar Items