Staff View: Neural fiber integrity in high-versus low-grade glioma using probabilistic fiber tracking

Neural fiber integrity in high-versus low-grade glioma using probabilistic fiber tracking

Rationale and Objectives: Gliomatous tumors are known to affect neural fiber integrity, either by displacement or destruction. The aim of this study is to investigate the integrity and distribution of the white matter tracts within and around the glioma regions using probabilistic fiber tracking. Ma...

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Main Authors:	Seow, Pohchoo, Hernowo, Aditya T., Narayanan, Vairavan, Wong, Jeannie Hsiu Ding, Bahuri, Nor Faizal Ahmad, Cham, Chun Yoong, Abdullah, Nor Aniza, Kadir, Khairul Azmi Abdul, Rahmat, Kartini, Ramli, Norlisah
Format:	Article
Published:	Elsevier 2021
Subjects:	R Medicine R Medicine (General) Medical technology
Online Access:	http://eprints.um.edu.my/34386/
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spelling	my.um.eprints.343862022-09-13T07:36:10Z http://eprints.um.edu.my/34386/ Neural fiber integrity in high-versus low-grade glioma using probabilistic fiber tracking Seow, Pohchoo Hernowo, Aditya T. Narayanan, Vairavan Wong, Jeannie Hsiu Ding Bahuri, Nor Faizal Ahmad Cham, Chun Yoong Abdullah, Nor Aniza Kadir, Khairul Azmi Abdul Rahmat, Kartini Ramli, Norlisah R Medicine R Medicine (General) Medical technology Rationale and Objectives: Gliomatous tumors are known to affect neural fiber integrity, either by displacement or destruction. The aim of this study is to investigate the integrity and distribution of the white matter tracts within and around the glioma regions using probabilistic fiber tracking. Material and Methods: Forty-two glioma patients were subjected to MRI using a standard tumor protocol with diffusion tensor imaging (DTI). The tumor and peritumor regions were delineated using snake model with reference to structural and diffusion MRI. A preprocessing pipeline of the structural MRI image, DTI data, and tumor regions was implemented. Tractography was performed to delineate the white matter (WM) tracts in the selected tumor regions via probabilistic fiber tracking. DTI indices were investigated through comparative mapping of WM tracts and tumor regions in low-grade gliomas (LGG) and high-grade gliomas (HGG). Results: Significant differences were seen in the planar tensor (C-p) in peritumor regions; mean diffusivity, axial diffusivity and pure isotropic diffusion in solid-enhancing tumor regions; and fractional anisotropy, axial diffusivity, pure anisotropic diffusion (q), total magnitude of diffusion tensor (L), relative anisotropy, C-p and spherical tensor (C-s) in solid nonenhancing tumor regions for affected WM tracts. In most cases of HGG, the WM tracts were not completely destroyed, but found intact inside the tumor. Discussion: Probabilistic fiber tracking revealed the existence and distribution of WM tracts inside tumor core for both LGG and HGG groups. There were more DTI indices in the solid nonenhancing tumor region, which showed significant differences between LGG and HGG. Elsevier 2021-12 Article PeerReviewed Seow, Pohchoo and Hernowo, Aditya T. and Narayanan, Vairavan and Wong, Jeannie Hsiu Ding and Bahuri, Nor Faizal Ahmad and Cham, Chun Yoong and Abdullah, Nor Aniza and Kadir, Khairul Azmi Abdul and Rahmat, Kartini and Ramli, Norlisah (2021) Neural fiber integrity in high-versus low-grade glioma using probabilistic fiber tracking. Academic Radiology, 28 (12). pp. 1721-1732. ISSN 1076-6332, DOI https://doi.org/10.1016/j.acra.2020.09.007 <https://doi.org/10.1016/j.acra.2020.09.007>. 10.1016/j.acra.2020.09.007
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine R Medicine (General) Medical technology
spellingShingle	R Medicine R Medicine (General) Medical technology Seow, Pohchoo Hernowo, Aditya T. Narayanan, Vairavan Wong, Jeannie Hsiu Ding Bahuri, Nor Faizal Ahmad Cham, Chun Yoong Abdullah, Nor Aniza Kadir, Khairul Azmi Abdul Rahmat, Kartini Ramli, Norlisah Neural fiber integrity in high-versus low-grade glioma using probabilistic fiber tracking
description	Rationale and Objectives: Gliomatous tumors are known to affect neural fiber integrity, either by displacement or destruction. The aim of this study is to investigate the integrity and distribution of the white matter tracts within and around the glioma regions using probabilistic fiber tracking. Material and Methods: Forty-two glioma patients were subjected to MRI using a standard tumor protocol with diffusion tensor imaging (DTI). The tumor and peritumor regions were delineated using snake model with reference to structural and diffusion MRI. A preprocessing pipeline of the structural MRI image, DTI data, and tumor regions was implemented. Tractography was performed to delineate the white matter (WM) tracts in the selected tumor regions via probabilistic fiber tracking. DTI indices were investigated through comparative mapping of WM tracts and tumor regions in low-grade gliomas (LGG) and high-grade gliomas (HGG). Results: Significant differences were seen in the planar tensor (C-p) in peritumor regions; mean diffusivity, axial diffusivity and pure isotropic diffusion in solid-enhancing tumor regions; and fractional anisotropy, axial diffusivity, pure anisotropic diffusion (q), total magnitude of diffusion tensor (L), relative anisotropy, C-p and spherical tensor (C-s) in solid nonenhancing tumor regions for affected WM tracts. In most cases of HGG, the WM tracts were not completely destroyed, but found intact inside the tumor. Discussion: Probabilistic fiber tracking revealed the existence and distribution of WM tracts inside tumor core for both LGG and HGG groups. There were more DTI indices in the solid nonenhancing tumor region, which showed significant differences between LGG and HGG.
format	Article
author	Seow, Pohchoo Hernowo, Aditya T. Narayanan, Vairavan Wong, Jeannie Hsiu Ding Bahuri, Nor Faizal Ahmad Cham, Chun Yoong Abdullah, Nor Aniza Kadir, Khairul Azmi Abdul Rahmat, Kartini Ramli, Norlisah
author_facet	Seow, Pohchoo Hernowo, Aditya T. Narayanan, Vairavan Wong, Jeannie Hsiu Ding Bahuri, Nor Faizal Ahmad Cham, Chun Yoong Abdullah, Nor Aniza Kadir, Khairul Azmi Abdul Rahmat, Kartini Ramli, Norlisah
author_sort	Seow, Pohchoo
title	Neural fiber integrity in high-versus low-grade glioma using probabilistic fiber tracking
title_short	Neural fiber integrity in high-versus low-grade glioma using probabilistic fiber tracking
title_full	Neural fiber integrity in high-versus low-grade glioma using probabilistic fiber tracking
title_fullStr	Neural fiber integrity in high-versus low-grade glioma using probabilistic fiber tracking
title_full_unstemmed	Neural fiber integrity in high-versus low-grade glioma using probabilistic fiber tracking
title_sort	neural fiber integrity in high-versus low-grade glioma using probabilistic fiber tracking
publisher	Elsevier
publishDate	2021
url	http://eprints.um.edu.my/34386/
_version_	1744649176799510528
score	13.211869

Neural fiber integrity in high-versus low-grade glioma using probabilistic fiber tracking

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