Staff View: Comparative expression of pro-inflammatory and apoptotic biosignatures in chronic HBV-infected patients with and without liver cirrhosis

Comparative expression of pro-inflammatory and apoptotic biosignatures in chronic HBV-infected patients with and without liver cirrhosis

The interplay of immune mediators is paramount to optimal host anti-viral immune responses, especially against chronic hepatitis B virus (HBV) infection. Here, we investigated the dynamic changes in host immune responses in chronic HBV-infected individuals with and without liver cirrhosis by examini...

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Main Authors:	Barathan, Muttiah, Riazalhosseini, Behnaz, Iyadorai, Thevambiga, Vellasamy, Kumutha Malar, Vadivelu, Jamuna, Chang, Li-Yen, Zulpa, Ahmad Khusairy, Larsson, Marie, Shankar, Esaki M., Mohamed, Rosmawati
Format:	Article
Published:	Elsevier 2021
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/34326/
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spelling	my.um.eprints.343262022-06-15T07:47:38Z http://eprints.um.edu.my/34326/ Comparative expression of pro-inflammatory and apoptotic biosignatures in chronic HBV-infected patients with and without liver cirrhosis Barathan, Muttiah Riazalhosseini, Behnaz Iyadorai, Thevambiga Vellasamy, Kumutha Malar Vadivelu, Jamuna Chang, Li-Yen Zulpa, Ahmad Khusairy Larsson, Marie Shankar, Esaki M. Mohamed, Rosmawati R Medicine The interplay of immune mediators is paramount to optimal host anti-viral immune responses, especially against chronic hepatitis B virus (HBV) infection. Here, we investigated the dynamic changes in host immune responses in chronic HBV-infected individuals with and without liver cirrhosis by examining the signatures of apoptosis and plasma levels of pro-inflammatory cytokines, chemokines, and cytotoxic proteins. A total of 40 chronic HBV patients with and without liver cirrhosis were studied for plasma levels of immune mediators, and signatures of apoptosis in peripheral blood mononuclear cells (PBMCs). The intracellular concentrations of reactive oxygen species (ROS) in patients with chronic HBV with liver cirrhosis was relatively higher as compared to chronic HBV patients. The onset of apoptosis was sustained due to ongoing liver inflammation in concert with plasma TNF-alpha and IL-6 levels. Plasma VEGF was upregulated among chronic HBV patients with liver cirrhosis, whereas CCL2, CCL5 and granzyme B levels were down-regulated. High levels of ROS, IL-6 and TNF-alpha correlated with ongoing inflammation among chronic HBV patients with liver cirrhosis, which likely attributed to the expression of biosignatures of apoptosis and activation in immune cells. Elsevier 2021-12 Article PeerReviewed Barathan, Muttiah and Riazalhosseini, Behnaz and Iyadorai, Thevambiga and Vellasamy, Kumutha Malar and Vadivelu, Jamuna and Chang, Li-Yen and Zulpa, Ahmad Khusairy and Larsson, Marie and Shankar, Esaki M. and Mohamed, Rosmawati (2021) Comparative expression of pro-inflammatory and apoptotic biosignatures in chronic HBV-infected patients with and without liver cirrhosis. Microbial Pathogenesis, 161 (A). ISSN 0882-4010, DOI https://doi.org/10.1016/j.micpath.2021.105231 <https://doi.org/10.1016/j.micpath.2021.105231>. 10.1016/j.micpath.2021.105231
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine
spellingShingle	R Medicine Barathan, Muttiah Riazalhosseini, Behnaz Iyadorai, Thevambiga Vellasamy, Kumutha Malar Vadivelu, Jamuna Chang, Li-Yen Zulpa, Ahmad Khusairy Larsson, Marie Shankar, Esaki M. Mohamed, Rosmawati Comparative expression of pro-inflammatory and apoptotic biosignatures in chronic HBV-infected patients with and without liver cirrhosis
description	The interplay of immune mediators is paramount to optimal host anti-viral immune responses, especially against chronic hepatitis B virus (HBV) infection. Here, we investigated the dynamic changes in host immune responses in chronic HBV-infected individuals with and without liver cirrhosis by examining the signatures of apoptosis and plasma levels of pro-inflammatory cytokines, chemokines, and cytotoxic proteins. A total of 40 chronic HBV patients with and without liver cirrhosis were studied for plasma levels of immune mediators, and signatures of apoptosis in peripheral blood mononuclear cells (PBMCs). The intracellular concentrations of reactive oxygen species (ROS) in patients with chronic HBV with liver cirrhosis was relatively higher as compared to chronic HBV patients. The onset of apoptosis was sustained due to ongoing liver inflammation in concert with plasma TNF-alpha and IL-6 levels. Plasma VEGF was upregulated among chronic HBV patients with liver cirrhosis, whereas CCL2, CCL5 and granzyme B levels were down-regulated. High levels of ROS, IL-6 and TNF-alpha correlated with ongoing inflammation among chronic HBV patients with liver cirrhosis, which likely attributed to the expression of biosignatures of apoptosis and activation in immune cells.
format	Article
author	Barathan, Muttiah Riazalhosseini, Behnaz Iyadorai, Thevambiga Vellasamy, Kumutha Malar Vadivelu, Jamuna Chang, Li-Yen Zulpa, Ahmad Khusairy Larsson, Marie Shankar, Esaki M. Mohamed, Rosmawati
author_facet	Barathan, Muttiah Riazalhosseini, Behnaz Iyadorai, Thevambiga Vellasamy, Kumutha Malar Vadivelu, Jamuna Chang, Li-Yen Zulpa, Ahmad Khusairy Larsson, Marie Shankar, Esaki M. Mohamed, Rosmawati
author_sort	Barathan, Muttiah
title	Comparative expression of pro-inflammatory and apoptotic biosignatures in chronic HBV-infected patients with and without liver cirrhosis
title_short	Comparative expression of pro-inflammatory and apoptotic biosignatures in chronic HBV-infected patients with and without liver cirrhosis
title_full	Comparative expression of pro-inflammatory and apoptotic biosignatures in chronic HBV-infected patients with and without liver cirrhosis
title_fullStr	Comparative expression of pro-inflammatory and apoptotic biosignatures in chronic HBV-infected patients with and without liver cirrhosis
title_full_unstemmed	Comparative expression of pro-inflammatory and apoptotic biosignatures in chronic HBV-infected patients with and without liver cirrhosis
title_sort	comparative expression of pro-inflammatory and apoptotic biosignatures in chronic hbv-infected patients with and without liver cirrhosis
publisher	Elsevier
publishDate	2021
url	http://eprints.um.edu.my/34326/
_version_	1736834290195365888
score	13.211869

Comparative expression of pro-inflammatory and apoptotic biosignatures in chronic HBV-infected patients with and without liver cirrhosis

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