Bioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering
Hydroxyapatite (HA) exhibits several desirable characteristics, but it still lacks osteoinduction, which is a necessary requirement for a bone scaffold. HA-based composites with different amounts of Bioglass (R) (BG) were prepared using spark plasma sintering (SPS). Careful selection of the SPS para...
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Faculty of Technology, University of Novi Sad
2021
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my.um.eprints.342542022-06-16T02:50:51Z http://eprints.um.edu.my/34254/ Bioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering Rizwan, Muhammad Chandio, Ali Dad Sohail, Muhammad Bashir, M. Nasir Yousuf, Sumra Alias, Rodianah Rehman, Hammad ur Hamdi Abd. Shukor, Mohd Hamdi Basirun, Wan Jeffrey TJ Mechanical engineering and machinery TK Electrical engineering. Electronics Nuclear engineering Hydroxyapatite (HA) exhibits several desirable characteristics, but it still lacks osteoinduction, which is a necessary requirement for a bone scaffold. HA-based composites with different amounts of Bioglass (R) (BG) were prepared using spark plasma sintering (SPS). Careful selection of the SPS parameters avoided undesirable reactions between the calcium phosphate (CaP) and bioglass (BG present in the form of powder and fibres), as confirmed through X-ray diffraction analysis. Scanning electron microscopy images of the composite scaffolds revealed a fibre like appearance of the glassy region. The in vitro bioactivity and biodegradation analyses were performed by immersing the composites in simulated body fluid (SBF) and tris(hydroxymethyl)aminomethane (Tris), respectively. The ability to obtain only the CaP phase and glassy phase with desirable bioactive and biodegradation behaviour, indicated that these SPS scaffolds can be employed as bone scaffolds for clinical trials, after further in vivo analyses. Faculty of Technology, University of Novi Sad 2021 Article PeerReviewed Rizwan, Muhammad and Chandio, Ali Dad and Sohail, Muhammad and Bashir, M. Nasir and Yousuf, Sumra and Alias, Rodianah and Rehman, Hammad ur and Hamdi Abd. Shukor, Mohd Hamdi and Basirun, Wan Jeffrey (2021) Bioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering. Processing and Application of Ceramics, 15 (3). pp. 270-278. ISSN 1820-6131, DOI https://doi.org/10.2298/PAC2103270R <https://doi.org/10.2298/PAC2103270R>. 10.2298/PAC2103270R |
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TJ Mechanical engineering and machinery TK Electrical engineering. Electronics Nuclear engineering Rizwan, Muhammad Chandio, Ali Dad Sohail, Muhammad Bashir, M. Nasir Yousuf, Sumra Alias, Rodianah Rehman, Hammad ur Hamdi Abd. Shukor, Mohd Hamdi Basirun, Wan Jeffrey Bioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering |
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Hydroxyapatite (HA) exhibits several desirable characteristics, but it still lacks osteoinduction, which is a necessary requirement for a bone scaffold. HA-based composites with different amounts of Bioglass (R) (BG) were prepared using spark plasma sintering (SPS). Careful selection of the SPS parameters avoided undesirable reactions between the calcium phosphate (CaP) and bioglass (BG present in the form of powder and fibres), as confirmed through X-ray diffraction analysis. Scanning electron microscopy images of the composite scaffolds revealed a fibre like appearance of the glassy region. The in vitro bioactivity and biodegradation analyses were performed by immersing the composites in simulated body fluid (SBF) and tris(hydroxymethyl)aminomethane (Tris), respectively. The ability to obtain only the CaP phase and glassy phase with desirable bioactive and biodegradation behaviour, indicated that these SPS scaffolds can be employed as bone scaffolds for clinical trials, after further in vivo analyses. |
| format |
Article |
| author |
Rizwan, Muhammad Chandio, Ali Dad Sohail, Muhammad Bashir, M. Nasir Yousuf, Sumra Alias, Rodianah Rehman, Hammad ur Hamdi Abd. Shukor, Mohd Hamdi Basirun, Wan Jeffrey |
| author_facet |
Rizwan, Muhammad Chandio, Ali Dad Sohail, Muhammad Bashir, M. Nasir Yousuf, Sumra Alias, Rodianah Rehman, Hammad ur Hamdi Abd. Shukor, Mohd Hamdi Basirun, Wan Jeffrey |
| author_sort |
Rizwan, Muhammad |
| title |
Bioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering |
| title_short |
Bioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering |
| title_full |
Bioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering |
| title_fullStr |
Bioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering |
| title_full_unstemmed |
Bioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering |
| title_sort |
bioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering |
| publisher |
Faculty of Technology, University of Novi Sad |
| publishDate |
2021 |
| url |
http://eprints.um.edu.my/34254/ |
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1738510717266427904 |
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13.211869 |