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Synthesis, growth, supramolecularity and antibacterial efficacy of 3,4-dimethoxybenzoic acid single crystals

In this paper, we have investigated the antibacterial potentials of organic single crystals, 3,4-dimethoxybenzoic acid (DMBA) grown by the slow evaporation solution growth technique. The crystallinity and structural orientation of as-grown DMBA compound was thoroughly studied using single-crystal X-...

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Main Authors: Rajendran, Archana, Sagadevan, Suresh, Lett, Jayasingh Anita, Kaliaraj, Gobi Saravanan, Fatimah, Is, Mohammad, Faruq, Al-Lohedan, Hamad A., Alshahateet, Solhe F., Podder, Jiban
Format: Article
Published: Elsevier 2021
Subjects:
QC Physics
QD Chemistry
T Technology (General)
Online Access:http://eprints.um.edu.my/34252/
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spelling my.um.eprints.342522022-09-08T07:49:50Z http://eprints.um.edu.my/34252/ Synthesis, growth, supramolecularity and antibacterial efficacy of 3,4-dimethoxybenzoic acid single crystals Rajendran, Archana Sagadevan, Suresh Lett, Jayasingh Anita Kaliaraj, Gobi Saravanan Fatimah, Is Mohammad, Faruq Al-Lohedan, Hamad A. Alshahateet, Solhe F. Podder, Jiban QC Physics QD Chemistry T Technology (General) In this paper, we have investigated the antibacterial potentials of organic single crystals, 3,4-dimethoxybenzoic acid (DMBA) grown by the slow evaporation solution growth technique. The crystallinity and structural orientation of as-grown DMBA compound was thoroughly studied using single-crystal X-ray diffraction and powder Xray diffraction (XRD) and found to be a triclinic crystal system with P1 space group. The Fourier transform infrared spectroscopy was used to understand the nature of bonding and functionalization, while the UV-Vis spectroscopic analysis provided the linear optical properties at the lower cutoff wavelength of 350 nm and transparency of 87%. Also, the photoluminescence spectrum shows the ultraviolet emission of the DMBA single crystal. Further, the antibacterial efficacy of DMBA crystals is investigated by means of percentage (%) inhibition and zone of inhibition (ZoI) against the two different bacterial stains of Klebsiella pneumoniae and Staphylococcus aureus. The results confirmed that the DMBA compound has higher activity against Staphylococcus aureus growth (75% inhibition efficiency and 5 mm ZoI at 100 mu g/mL) than that of Klebsiella pneumoniae (55% inhibition and 2 mm ZoI at 100 mu g/mL) and thereby providing evidence for the potential role of the DMBA compound in future medicinal drugs. Elsevier 2021-02 Article PeerReviewed Rajendran, Archana and Sagadevan, Suresh and Lett, Jayasingh Anita and Kaliaraj, Gobi Saravanan and Fatimah, Is and Mohammad, Faruq and Al-Lohedan, Hamad A. and Alshahateet, Solhe F. and Podder, Jiban (2021) Synthesis, growth, supramolecularity and antibacterial efficacy of 3,4-dimethoxybenzoic acid single crystals. Chemical Physics Letters, 764. ISSN 0009-2614, DOI https://doi.org/10.1016/j.cplett.2020.138269 <https://doi.org/10.1016/j.cplett.2020.138269>. 10.1016/j.cplett.2020.138269
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QC Physics
QD Chemistry
T Technology (General)
spellingShingle QC Physics
QD Chemistry
T Technology (General)
Rajendran, Archana
Sagadevan, Suresh
Lett, Jayasingh Anita
Kaliaraj, Gobi Saravanan
Fatimah, Is
Mohammad, Faruq
Al-Lohedan, Hamad A.
Alshahateet, Solhe F.
Podder, Jiban
Synthesis, growth, supramolecularity and antibacterial efficacy of 3,4-dimethoxybenzoic acid single crystals
description In this paper, we have investigated the antibacterial potentials of organic single crystals, 3,4-dimethoxybenzoic acid (DMBA) grown by the slow evaporation solution growth technique. The crystallinity and structural orientation of as-grown DMBA compound was thoroughly studied using single-crystal X-ray diffraction and powder Xray diffraction (XRD) and found to be a triclinic crystal system with P1 space group. The Fourier transform infrared spectroscopy was used to understand the nature of bonding and functionalization, while the UV-Vis spectroscopic analysis provided the linear optical properties at the lower cutoff wavelength of 350 nm and transparency of 87%. Also, the photoluminescence spectrum shows the ultraviolet emission of the DMBA single crystal. Further, the antibacterial efficacy of DMBA crystals is investigated by means of percentage (%) inhibition and zone of inhibition (ZoI) against the two different bacterial stains of Klebsiella pneumoniae and Staphylococcus aureus. The results confirmed that the DMBA compound has higher activity against Staphylococcus aureus growth (75% inhibition efficiency and 5 mm ZoI at 100 mu g/mL) than that of Klebsiella pneumoniae (55% inhibition and 2 mm ZoI at 100 mu g/mL) and thereby providing evidence for the potential role of the DMBA compound in future medicinal drugs.
format Article
author Rajendran, Archana
Sagadevan, Suresh
Lett, Jayasingh Anita
Kaliaraj, Gobi Saravanan
Fatimah, Is
Mohammad, Faruq
Al-Lohedan, Hamad A.
Alshahateet, Solhe F.
Podder, Jiban
author_facet Rajendran, Archana
Sagadevan, Suresh
Lett, Jayasingh Anita
Kaliaraj, Gobi Saravanan
Fatimah, Is
Mohammad, Faruq
Al-Lohedan, Hamad A.
Alshahateet, Solhe F.
Podder, Jiban
author_sort Rajendran, Archana
title Synthesis, growth, supramolecularity and antibacterial efficacy of 3,4-dimethoxybenzoic acid single crystals
title_short Synthesis, growth, supramolecularity and antibacterial efficacy of 3,4-dimethoxybenzoic acid single crystals
title_full Synthesis, growth, supramolecularity and antibacterial efficacy of 3,4-dimethoxybenzoic acid single crystals
title_fullStr Synthesis, growth, supramolecularity and antibacterial efficacy of 3,4-dimethoxybenzoic acid single crystals
title_full_unstemmed Synthesis, growth, supramolecularity and antibacterial efficacy of 3,4-dimethoxybenzoic acid single crystals
title_sort synthesis, growth, supramolecularity and antibacterial efficacy of 3,4-dimethoxybenzoic acid single crystals
publisher Elsevier
publishDate 2021
url http://eprints.um.edu.my/34252/
_version_ 1744649166903050240
score 13.211869

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