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Synergistic effects of Cu-doped ZnO nanoantibiotic against Gram-positive bacterial strains

A viable hydrothermal technique has been explored for the synthesis of copper doped Zinc oxide nanoparticles (Cu-doped ZnO-NPs) based on the precursor's mixture of Copper-II chloride dihydrate (CuCl2.2H(2)O), Zinc chloride (ZnCl2), and potassium hydroxide (KOH). X-ray diffraction (XRD) reported...

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Main Authors: Khalid, Awais, Ahmad, Pervaiz, Alharthi, Abdulrahman I., Muhammad, Saleh, Khandaker, Mayeen Uddin, Faruque, Mohammad Rashed Iqbal, Din, Israf Ud, Alotaibi, Mshari A., Khan, Abdulhameed
Format: Article
Published: Public Library of Science 2021
Subjects:
Q Science (General)
QC Physics
QD Chemistry
Online Access:http://eprints.um.edu.my/34197/
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spelling my.um.eprints.341972022-09-07T07:28:23Z http://eprints.um.edu.my/34197/ Synergistic effects of Cu-doped ZnO nanoantibiotic against Gram-positive bacterial strains Khalid, Awais Ahmad, Pervaiz Alharthi, Abdulrahman I. Muhammad, Saleh Khandaker, Mayeen Uddin Faruque, Mohammad Rashed Iqbal Din, Israf Ud Alotaibi, Mshari A. Khan, Abdulhameed Q Science (General) QC Physics QD Chemistry A viable hydrothermal technique has been explored for the synthesis of copper doped Zinc oxide nanoparticles (Cu-doped ZnO-NPs) based on the precursor's mixture of Copper-II chloride dihydrate (CuCl2.2H(2)O), Zinc chloride (ZnCl2), and potassium hydroxide (KOH). X-ray diffraction (XRD) reported the hexagonal wurtzite structure of the synthesized Cu-doped ZnO-NPs. The surface morphology is checked via field emission scanning electron microscopy (FE-SEM), whereas, the elemental compositions of the samples were confirmed by Raman, and X-ray photoelectron spectroscopy (XPS), respectively. The as-obtained ZnO-NPs and Cu-doped ZnO-NPs were then tested for their antibacterial activity against clinical isolates of Gram-positive (Staphylococcus aureus, Streptococcus pyogenes) and Gram-negative (Escherichia coli, Klebsiella pneumonia) bacteria via agar well diffusion method. The zone of inhibition (ZOI) for Cu-doped ZnO-NPs was found to be 24 and 19 mm against S. Aureus and S. pyogenes, and 18 and 11 mm against E. coli and K. pneumoniae, respectively. The synthesized Cu-doped ZnO-NPs can thus be found as a potential nano antibiotic against Gram-positive multi-drug resistant bacterial strains. Public Library of Science 2021-05-14 Article PeerReviewed Khalid, Awais and Ahmad, Pervaiz and Alharthi, Abdulrahman I. and Muhammad, Saleh and Khandaker, Mayeen Uddin and Faruque, Mohammad Rashed Iqbal and Din, Israf Ud and Alotaibi, Mshari A. and Khan, Abdulhameed (2021) Synergistic effects of Cu-doped ZnO nanoantibiotic against Gram-positive bacterial strains. PLoS ONE, 16 (5). ISSN 1932-6203, DOI https://doi.org/10.1371/journal.pone.0251082 <https://doi.org/10.1371/journal.pone.0251082>. 10.1371/journal.pone.0251082
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
QC Physics
QD Chemistry
spellingShingle Q Science (General)
QC Physics
QD Chemistry
Khalid, Awais
Ahmad, Pervaiz
Alharthi, Abdulrahman I.
Muhammad, Saleh
Khandaker, Mayeen Uddin
Faruque, Mohammad Rashed Iqbal
Din, Israf Ud
Alotaibi, Mshari A.
Khan, Abdulhameed
Synergistic effects of Cu-doped ZnO nanoantibiotic against Gram-positive bacterial strains
description A viable hydrothermal technique has been explored for the synthesis of copper doped Zinc oxide nanoparticles (Cu-doped ZnO-NPs) based on the precursor's mixture of Copper-II chloride dihydrate (CuCl2.2H(2)O), Zinc chloride (ZnCl2), and potassium hydroxide (KOH). X-ray diffraction (XRD) reported the hexagonal wurtzite structure of the synthesized Cu-doped ZnO-NPs. The surface morphology is checked via field emission scanning electron microscopy (FE-SEM), whereas, the elemental compositions of the samples were confirmed by Raman, and X-ray photoelectron spectroscopy (XPS), respectively. The as-obtained ZnO-NPs and Cu-doped ZnO-NPs were then tested for their antibacterial activity against clinical isolates of Gram-positive (Staphylococcus aureus, Streptococcus pyogenes) and Gram-negative (Escherichia coli, Klebsiella pneumonia) bacteria via agar well diffusion method. The zone of inhibition (ZOI) for Cu-doped ZnO-NPs was found to be 24 and 19 mm against S. Aureus and S. pyogenes, and 18 and 11 mm against E. coli and K. pneumoniae, respectively. The synthesized Cu-doped ZnO-NPs can thus be found as a potential nano antibiotic against Gram-positive multi-drug resistant bacterial strains.
format Article
author Khalid, Awais
Ahmad, Pervaiz
Alharthi, Abdulrahman I.
Muhammad, Saleh
Khandaker, Mayeen Uddin
Faruque, Mohammad Rashed Iqbal
Din, Israf Ud
Alotaibi, Mshari A.
Khan, Abdulhameed
author_facet Khalid, Awais
Ahmad, Pervaiz
Alharthi, Abdulrahman I.
Muhammad, Saleh
Khandaker, Mayeen Uddin
Faruque, Mohammad Rashed Iqbal
Din, Israf Ud
Alotaibi, Mshari A.
Khan, Abdulhameed
author_sort Khalid, Awais
title Synergistic effects of Cu-doped ZnO nanoantibiotic against Gram-positive bacterial strains
title_short Synergistic effects of Cu-doped ZnO nanoantibiotic against Gram-positive bacterial strains
title_full Synergistic effects of Cu-doped ZnO nanoantibiotic against Gram-positive bacterial strains
title_fullStr Synergistic effects of Cu-doped ZnO nanoantibiotic against Gram-positive bacterial strains
title_full_unstemmed Synergistic effects of Cu-doped ZnO nanoantibiotic against Gram-positive bacterial strains
title_sort synergistic effects of cu-doped zno nanoantibiotic against gram-positive bacterial strains
publisher Public Library of Science
publishDate 2021
url http://eprints.um.edu.my/34197/
_version_ 1744649163351523328
score 13.211869

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