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Spectrum of imaging findings of papillary breast disease: A radiopathological review in a tertiary center

To evaluate the clinical and imaging findings of papillary breast neoplasm and review the pathologic correlation at a tertiary center. Retrospective study of patients diagnosed with benign and malignant papillary lesions between 2008 to 2018. 147 patients were identified with histology diagnosis of...

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Main Authors:	Fadzli, Farhana, Rahmat, Kartini, Ramli, Marlina Tanty, Rozalli, Faizatul Izza, Hooi, Teoh Kean, Fadzli, Ahmad Nazran, Hoong, See Mee, Mohd Ramli, Norlisah, Mohd Taib, Nur Aishah
Format:	Article
Published:	Lippincott, Williams & Wilkins 2021
Subjects:	R Medicine (General) RC Internal medicine
Online Access:	http://eprints.um.edu.my/34179/
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spelling	my.um.eprints.341792022-09-02T08:22:59Z http://eprints.um.edu.my/34179/ Spectrum of imaging findings of papillary breast disease: A radiopathological review in a tertiary center Fadzli, Farhana Rahmat, Kartini Ramli, Marlina Tanty Rozalli, Faizatul Izza Hooi, Teoh Kean Fadzli, Ahmad Nazran Hoong, See Mee Mohd Ramli, Norlisah Mohd Taib, Nur Aishah R Medicine (General) RC Internal medicine To evaluate the clinical and imaging findings of papillary breast neoplasm and review the pathologic correlation at a tertiary center. Retrospective study of patients diagnosed with benign and malignant papillary lesions between 2008 to 2018. 147 patients were identified with histology diagnosis of papillary lesions. The clinical, imaging, and pathological characteristics were reviewed. Patient cohort included 147 women diagnosed with papillary lesions (mean age at diagnosis 53.8 years) and were divided into 3 histology groups (benign, atypical, and malignant). Common clinical presentations were breast lump (n = 60) and nipple discharge (n = 29), 48 patients were asymptomatic. Only 37 were detected as a mass lesion on mammogram. The presence of mass lesion on mammogram was the most common feature in all 3 papillary lesion groups, and with the presence of asymmetric density, were the 2 mammographic features significantly associated (P < .05) with malignancy. All lesions were detected on ultrasound. The most common sonographic features for all 3 groups were the presence of a mass and irregular shape. Among all the sonographic features assessed, larger size, presence of vascularity and absence of dilated ducts were significantly associated (P < .05) with malignancy. Feature pattern recognition of the variety of benign, atypical and malignant papillary neoplasm on ultrasound and mammogram, with emphasis on size, presence of vascularity and dilated ducts on ultrasound and presence of mass, and architectural distortion on mammogram, is important in the assessment of patients with suspected ductal lesions to facilitate optimal treatment and surgical care. Lippincott, Williams & Wilkins 2021-04-23 Article PeerReviewed Fadzli, Farhana and Rahmat, Kartini and Ramli, Marlina Tanty and Rozalli, Faizatul Izza and Hooi, Teoh Kean and Fadzli, Ahmad Nazran and Hoong, See Mee and Mohd Ramli, Norlisah and Mohd Taib, Nur Aishah (2021) Spectrum of imaging findings of papillary breast disease: A radiopathological review in a tertiary center. Medicine, 100 (16). ISSN 0025-7974, DOI https://doi.org/10.1097/MD.0000000000025297 <https://doi.org/10.1097/MD.0000000000025297>. 10.1097/MD.0000000000025297
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine (General) RC Internal medicine
spellingShingle	R Medicine (General) RC Internal medicine Fadzli, Farhana Rahmat, Kartini Ramli, Marlina Tanty Rozalli, Faizatul Izza Hooi, Teoh Kean Fadzli, Ahmad Nazran Hoong, See Mee Mohd Ramli, Norlisah Mohd Taib, Nur Aishah Spectrum of imaging findings of papillary breast disease: A radiopathological review in a tertiary center
description	To evaluate the clinical and imaging findings of papillary breast neoplasm and review the pathologic correlation at a tertiary center. Retrospective study of patients diagnosed with benign and malignant papillary lesions between 2008 to 2018. 147 patients were identified with histology diagnosis of papillary lesions. The clinical, imaging, and pathological characteristics were reviewed. Patient cohort included 147 women diagnosed with papillary lesions (mean age at diagnosis 53.8 years) and were divided into 3 histology groups (benign, atypical, and malignant). Common clinical presentations were breast lump (n = 60) and nipple discharge (n = 29), 48 patients were asymptomatic. Only 37 were detected as a mass lesion on mammogram. The presence of mass lesion on mammogram was the most common feature in all 3 papillary lesion groups, and with the presence of asymmetric density, were the 2 mammographic features significantly associated (P < .05) with malignancy. All lesions were detected on ultrasound. The most common sonographic features for all 3 groups were the presence of a mass and irregular shape. Among all the sonographic features assessed, larger size, presence of vascularity and absence of dilated ducts were significantly associated (P < .05) with malignancy. Feature pattern recognition of the variety of benign, atypical and malignant papillary neoplasm on ultrasound and mammogram, with emphasis on size, presence of vascularity and dilated ducts on ultrasound and presence of mass, and architectural distortion on mammogram, is important in the assessment of patients with suspected ductal lesions to facilitate optimal treatment and surgical care.
format	Article
author	Fadzli, Farhana Rahmat, Kartini Ramli, Marlina Tanty Rozalli, Faizatul Izza Hooi, Teoh Kean Fadzli, Ahmad Nazran Hoong, See Mee Mohd Ramli, Norlisah Mohd Taib, Nur Aishah
author_facet	Fadzli, Farhana Rahmat, Kartini Ramli, Marlina Tanty Rozalli, Faizatul Izza Hooi, Teoh Kean Fadzli, Ahmad Nazran Hoong, See Mee Mohd Ramli, Norlisah Mohd Taib, Nur Aishah
author_sort	Fadzli, Farhana
title	Spectrum of imaging findings of papillary breast disease: A radiopathological review in a tertiary center
title_short	Spectrum of imaging findings of papillary breast disease: A radiopathological review in a tertiary center
title_full	Spectrum of imaging findings of papillary breast disease: A radiopathological review in a tertiary center
title_fullStr	Spectrum of imaging findings of papillary breast disease: A radiopathological review in a tertiary center
title_full_unstemmed	Spectrum of imaging findings of papillary breast disease: A radiopathological review in a tertiary center
title_sort	spectrum of imaging findings of papillary breast disease: a radiopathological review in a tertiary center
publisher	Lippincott, Williams & Wilkins
publishDate	2021
url	http://eprints.um.edu.my/34179/
_version_	1744649162100572160
score	13.211869

Spectrum of imaging findings of papillary breast disease: A radiopathological review in a tertiary center

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