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Ibuprofen-loaded chitosan-lipid nanoconjugate hydrogel with gum arabic: green synthesis, characterisation, in vitro kinetics mechanistic release study and pge2 production test

Ibuprofen is a well-known non-steroidal anti-inflammatory (NSAID) medicine that is often used to treat inflammation in general. When given orally, it produces gastrointestinal issues which lead to lower patient compliance. Ibuprofen transdermal administration improves both patient compliance and the...

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Main Authors: Mahmood, Syed, Almurisi, Samah Hamed, AL-Japairai, Khater, Hilles, Ayah Rebhi, Alelwani, Walla, Bannunah, Azzah M., Alshammari, Farhan, Alheibshy, Fawaz
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Published: MDPI 2021
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QD Chemistry
Online Access:http://eprints.um.edu.my/33976/
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spelling my.um.eprints.339762022-07-01T08:02:57Z http://eprints.um.edu.my/33976/ Ibuprofen-loaded chitosan-lipid nanoconjugate hydrogel with gum arabic: green synthesis, characterisation, in vitro kinetics mechanistic release study and pge2 production test Mahmood, Syed Almurisi, Samah Hamed AL-Japairai, Khater Hilles, Ayah Rebhi Alelwani, Walla Bannunah, Azzah M. Alshammari, Farhan Alheibshy, Fawaz QD Chemistry Ibuprofen is a well-known non-steroidal anti-inflammatory (NSAID) medicine that is often used to treat inflammation in general. When given orally, it produces gastrointestinal issues which lead to lower patient compliance. Ibuprofen transdermal administration improves both patient compliance and the efficacy of the drug. Nanoconjugation hydrogels were proposed as a controlled transdermal delivery tool for ibuprofen. Six formulations were prepared using different compositions including chitosan, lipids, gum arabic, and polyvinyl alcohol, through ionic interaction, maturation, and freeze-thaw methods. The formulations were characterised by size, drug conjugation efficiency, differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). Further analysis of optimised hydrogels was performed, including X-ray diffraction (XRD), rheology, gel fraction and swelling ability, in vitro drug release, and in vitro macrophage prostaglandin E2 (PGE(2)) production testing. The effects of ibuprofen's electrostatic interaction with a lipid or polymer on the physicochemical and dissolution characterisation of ibuprofen hydrogels were evaluated. The results showed that the S3 (with lipid conjugation) hydrogel provided higher conjugation efficiency and prolonged drug release compared with the S6 hydrogel. MDPI 2021-12 Article PeerReviewed Mahmood, Syed and Almurisi, Samah Hamed and AL-Japairai, Khater and Hilles, Ayah Rebhi and Alelwani, Walla and Bannunah, Azzah M. and Alshammari, Farhan and Alheibshy, Fawaz (2021) Ibuprofen-loaded chitosan-lipid nanoconjugate hydrogel with gum arabic: green synthesis, characterisation, in vitro kinetics mechanistic release study and pge2 production test. Gels, 7 (4). ISSN 2310-2861, DOI https://doi.org/10.3390/gels7040254 <https://doi.org/10.3390/gels7040254>. 10.3390/gels7040254
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
spellingShingle QD Chemistry
Mahmood, Syed
Almurisi, Samah Hamed
AL-Japairai, Khater
Hilles, Ayah Rebhi
Alelwani, Walla
Bannunah, Azzah M.
Alshammari, Farhan
Alheibshy, Fawaz
Ibuprofen-loaded chitosan-lipid nanoconjugate hydrogel with gum arabic: green synthesis, characterisation, in vitro kinetics mechanistic release study and pge2 production test
description Ibuprofen is a well-known non-steroidal anti-inflammatory (NSAID) medicine that is often used to treat inflammation in general. When given orally, it produces gastrointestinal issues which lead to lower patient compliance. Ibuprofen transdermal administration improves both patient compliance and the efficacy of the drug. Nanoconjugation hydrogels were proposed as a controlled transdermal delivery tool for ibuprofen. Six formulations were prepared using different compositions including chitosan, lipids, gum arabic, and polyvinyl alcohol, through ionic interaction, maturation, and freeze-thaw methods. The formulations were characterised by size, drug conjugation efficiency, differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). Further analysis of optimised hydrogels was performed, including X-ray diffraction (XRD), rheology, gel fraction and swelling ability, in vitro drug release, and in vitro macrophage prostaglandin E2 (PGE(2)) production testing. The effects of ibuprofen's electrostatic interaction with a lipid or polymer on the physicochemical and dissolution characterisation of ibuprofen hydrogels were evaluated. The results showed that the S3 (with lipid conjugation) hydrogel provided higher conjugation efficiency and prolonged drug release compared with the S6 hydrogel.
format Article
author Mahmood, Syed
Almurisi, Samah Hamed
AL-Japairai, Khater
Hilles, Ayah Rebhi
Alelwani, Walla
Bannunah, Azzah M.
Alshammari, Farhan
Alheibshy, Fawaz
author_facet Mahmood, Syed
Almurisi, Samah Hamed
AL-Japairai, Khater
Hilles, Ayah Rebhi
Alelwani, Walla
Bannunah, Azzah M.
Alshammari, Farhan
Alheibshy, Fawaz
author_sort Mahmood, Syed
title Ibuprofen-loaded chitosan-lipid nanoconjugate hydrogel with gum arabic: green synthesis, characterisation, in vitro kinetics mechanistic release study and pge2 production test
title_short Ibuprofen-loaded chitosan-lipid nanoconjugate hydrogel with gum arabic: green synthesis, characterisation, in vitro kinetics mechanistic release study and pge2 production test
title_full Ibuprofen-loaded chitosan-lipid nanoconjugate hydrogel with gum arabic: green synthesis, characterisation, in vitro kinetics mechanistic release study and pge2 production test
title_fullStr Ibuprofen-loaded chitosan-lipid nanoconjugate hydrogel with gum arabic: green synthesis, characterisation, in vitro kinetics mechanistic release study and pge2 production test
title_full_unstemmed Ibuprofen-loaded chitosan-lipid nanoconjugate hydrogel with gum arabic: green synthesis, characterisation, in vitro kinetics mechanistic release study and pge2 production test
title_sort ibuprofen-loaded chitosan-lipid nanoconjugate hydrogel with gum arabic: green synthesis, characterisation, in vitro kinetics mechanistic release study and pge2 production test
publisher MDPI
publishDate 2021
url http://eprints.um.edu.my/33976/
_version_ 1738510696428077056
score 13.211869

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