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Bioefficacy of mosquito mat vaporizers and associated metabolic detoxication mechanisms in Aedes aegypti (Linnaeus) in Selangor, Malaysia: A statewide assessment

This study aims to examine the efficacy of mosquito mat vaporizers on Aedes aegypti and their associated metabolic detoxication mechanisms. For this purpose, Aedes aegypti (Linnaeus) was collected from nine districts in Selangor, Malaysia and tested with mosquito vaporizing mat bioassays. The same p...

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Main Authors: Azratul-Hizayu, T., Chen, C. D., Lau, K. W., Azrizal-Wahid, N., Tan, T. K., Lim, Y. A. L., Sofian-Azirun, M., Low, V. L.
Format: Article
Published: Malaysian Soc Parasitology Tropical Medicine 2021
Subjects:
Q Science (General)
Online Access:http://eprints.um.edu.my/33893/
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spelling my.um.eprints.338932022-07-17T04:25:53Z http://eprints.um.edu.my/33893/ Bioefficacy of mosquito mat vaporizers and associated metabolic detoxication mechanisms in Aedes aegypti (Linnaeus) in Selangor, Malaysia: A statewide assessment Azratul-Hizayu, T. Chen, C. D. Lau, K. W. Azrizal-Wahid, N. Tan, T. K. Lim, Y. A. L. Sofian-Azirun, M. Low, V. L. Q Science (General) This study aims to examine the efficacy of mosquito mat vaporizers on Aedes aegypti and their associated metabolic detoxication mechanisms. For this purpose, Aedes aegypti (Linnaeus) was collected from nine districts in Selangor, Malaysia and tested with mosquito vaporizing mat bioassays. The same populations were also subjected to biochemical assays to investigate activities of detoxifying enzymes, namely non-specific esterase (EST), glutathione-S-transferase (GST) and mixed function oxidase (MFO). The efficacy of Ae. aegypti on the active ingredients tested in decreasing order were d- allethrin > dimefluthrin > prallethrin with PBO > prallethrin. The results further indicated significant enhancement mean levels of EST, GST and MFO in pyrethroid-resistant populations. The mortality rate of Ae. aegypti in response to pyrethroid active ingredients was associated with MFO activity, suggesting it is an important detoxification enzyme for the populations tested. In view of the presence of resistance against household insecticide products, pyrethroid efficacy on Ae. aegypti populations needs to be monitored closely to ensure the implementation of an effective vector control program in Malaysia. Malaysian Soc Parasitology Tropical Medicine 2021-09 Article PeerReviewed Azratul-Hizayu, T. and Chen, C. D. and Lau, K. W. and Azrizal-Wahid, N. and Tan, T. K. and Lim, Y. A. L. and Sofian-Azirun, M. and Low, V. L. (2021) Bioefficacy of mosquito mat vaporizers and associated metabolic detoxication mechanisms in Aedes aegypti (Linnaeus) in Selangor, Malaysia: A statewide assessment. Tropical Biomedicine, 38 (3). pp. 327-337. ISSN 0127-5720, DOI https://doi.org/10.47665/tb.38.3.073 <https://doi.org/10.47665/tb.38.3.073>. 10.47665/tb.38.3.073
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
spellingShingle Q Science (General)
Azratul-Hizayu, T.
Chen, C. D.
Lau, K. W.
Azrizal-Wahid, N.
Tan, T. K.
Lim, Y. A. L.
Sofian-Azirun, M.
Low, V. L.
Bioefficacy of mosquito mat vaporizers and associated metabolic detoxication mechanisms in Aedes aegypti (Linnaeus) in Selangor, Malaysia: A statewide assessment
description This study aims to examine the efficacy of mosquito mat vaporizers on Aedes aegypti and their associated metabolic detoxication mechanisms. For this purpose, Aedes aegypti (Linnaeus) was collected from nine districts in Selangor, Malaysia and tested with mosquito vaporizing mat bioassays. The same populations were also subjected to biochemical assays to investigate activities of detoxifying enzymes, namely non-specific esterase (EST), glutathione-S-transferase (GST) and mixed function oxidase (MFO). The efficacy of Ae. aegypti on the active ingredients tested in decreasing order were d- allethrin > dimefluthrin > prallethrin with PBO > prallethrin. The results further indicated significant enhancement mean levels of EST, GST and MFO in pyrethroid-resistant populations. The mortality rate of Ae. aegypti in response to pyrethroid active ingredients was associated with MFO activity, suggesting it is an important detoxification enzyme for the populations tested. In view of the presence of resistance against household insecticide products, pyrethroid efficacy on Ae. aegypti populations needs to be monitored closely to ensure the implementation of an effective vector control program in Malaysia.
format Article
author Azratul-Hizayu, T.
Chen, C. D.
Lau, K. W.
Azrizal-Wahid, N.
Tan, T. K.
Lim, Y. A. L.
Sofian-Azirun, M.
Low, V. L.
author_facet Azratul-Hizayu, T.
Chen, C. D.
Lau, K. W.
Azrizal-Wahid, N.
Tan, T. K.
Lim, Y. A. L.
Sofian-Azirun, M.
Low, V. L.
author_sort Azratul-Hizayu, T.
title Bioefficacy of mosquito mat vaporizers and associated metabolic detoxication mechanisms in Aedes aegypti (Linnaeus) in Selangor, Malaysia: A statewide assessment
title_short Bioefficacy of mosquito mat vaporizers and associated metabolic detoxication mechanisms in Aedes aegypti (Linnaeus) in Selangor, Malaysia: A statewide assessment
title_full Bioefficacy of mosquito mat vaporizers and associated metabolic detoxication mechanisms in Aedes aegypti (Linnaeus) in Selangor, Malaysia: A statewide assessment
title_fullStr Bioefficacy of mosquito mat vaporizers and associated metabolic detoxication mechanisms in Aedes aegypti (Linnaeus) in Selangor, Malaysia: A statewide assessment
title_full_unstemmed Bioefficacy of mosquito mat vaporizers and associated metabolic detoxication mechanisms in Aedes aegypti (Linnaeus) in Selangor, Malaysia: A statewide assessment
title_sort bioefficacy of mosquito mat vaporizers and associated metabolic detoxication mechanisms in aedes aegypti (linnaeus) in selangor, malaysia: a statewide assessment
publisher Malaysian Soc Parasitology Tropical Medicine
publishDate 2021
url http://eprints.um.edu.my/33893/
_version_ 1739828480007208960
score 13.211869

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