Staff View: Changing predominant SARS-CoV-2 lineages drives successive COVID-19 waves in Malaysia, February 2020 to March 2021

Changing predominant SARS-CoV-2 lineages drives successive COVID-19 waves in Malaysia, February 2020 to March 2021

Malaysia has experienced three waves of coronavirus disease 2019 (COVID-19) as of March 31, 2021. We studied the associated molecular epidemiology and SARS-CoV-2 seroprevalence during the third wave. We obtained 60 whole-genome SARS-CoV-2 sequences between October 2020 and January 2021 in Kuala Lump...

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Main Authors:	Sam, I-Ching, Chong, Yoong Min, Abdullah, Azwani, Fu, Jolene Yin Ling, Hasan, M. Shahnaz, Jamaluddin, Fadhil Hadi, Kamarulzaman, Adeeba, Lim, Koo Koon, Nor, Mohd Afiq Mohd, Pang, Yong Kek, Ponnampalavanar, Sasheela, Shahib, Muhammad Fadzil, Omar, Sharifah Faridah Syed, Chan, Jonathan Chia Jui, Perera, David, Chan, Yoke Fun
Format:	Article
Published:	Wiley 2022
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/33694/
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id	my.um.eprints.33694
record_format	eprints
spelling	my.um.eprints.336942022-07-20T06:47:58Z http://eprints.um.edu.my/33694/ Changing predominant SARS-CoV-2 lineages drives successive COVID-19 waves in Malaysia, February 2020 to March 2021 Sam, I-Ching Chong, Yoong Min Abdullah, Azwani Fu, Jolene Yin Ling Hasan, M. Shahnaz Jamaluddin, Fadhil Hadi Kamarulzaman, Adeeba Lim, Koo Koon Nor, Mohd Afiq Mohd Pang, Yong Kek Ponnampalavanar, Sasheela Shahib, Muhammad Fadzil Omar, Sharifah Faridah Syed Chan, Jonathan Chia Jui Perera, David Chan, Yoke Fun R Medicine Malaysia has experienced three waves of coronavirus disease 2019 (COVID-19) as of March 31, 2021. We studied the associated molecular epidemiology and SARS-CoV-2 seroprevalence during the third wave. We obtained 60 whole-genome SARS-CoV-2 sequences between October 2020 and January 2021 in Kuala Lumpur/Selangor and analyzed 989 available Malaysian sequences. We tested 653 residual serum samples collected between December 2020 to April 2021 for anti-SARS-CoV-2 total antibodies, as a proxy for population immunity. The first wave (January 2020) comprised sporadic imported cases from China of early Pango lineages A and B. The second wave (March-June 2020) was associated with lineage B.6. The ongoing third wave (from September 2020) was propagated by a state election in Sabah. It is due to lineage B.1.524 viruses containing spike mutations D614G and A701V. Lineages B.1.459, B.1.470, and B.1.466.2 were likely imported from the region and confined to Sarawak state. Direct age-standardized seroprevalence in Kuala Lumpur/Selangor was 3.0%. The second and third waves were driven by super-spreading events and different circulating lineages. Malaysia is highly susceptible to further waves, especially as alpha (B.1.1.7) and beta (B.1.351) variants of concern were first detected in December 2020/January 2021. Increased genomic surveillance is critical. Wiley 2022-03 Article PeerReviewed Sam, I-Ching and Chong, Yoong Min and Abdullah, Azwani and Fu, Jolene Yin Ling and Hasan, M. Shahnaz and Jamaluddin, Fadhil Hadi and Kamarulzaman, Adeeba and Lim, Koo Koon and Nor, Mohd Afiq Mohd and Pang, Yong Kek and Ponnampalavanar, Sasheela and Shahib, Muhammad Fadzil and Omar, Sharifah Faridah Syed and Chan, Jonathan Chia Jui and Perera, David and Chan, Yoke Fun (2022) Changing predominant SARS-CoV-2 lineages drives successive COVID-19 waves in Malaysia, February 2020 to March 2021. Journal of Medical Virology, 94 (3). pp. 1146-1153. ISSN 0146-6615, DOI https://doi.org/10.1002/jmv.27441 <https://doi.org/10.1002/jmv.27441>. 10.1002/jmv.27441
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine
spellingShingle	R Medicine Sam, I-Ching Chong, Yoong Min Abdullah, Azwani Fu, Jolene Yin Ling Hasan, M. Shahnaz Jamaluddin, Fadhil Hadi Kamarulzaman, Adeeba Lim, Koo Koon Nor, Mohd Afiq Mohd Pang, Yong Kek Ponnampalavanar, Sasheela Shahib, Muhammad Fadzil Omar, Sharifah Faridah Syed Chan, Jonathan Chia Jui Perera, David Chan, Yoke Fun Changing predominant SARS-CoV-2 lineages drives successive COVID-19 waves in Malaysia, February 2020 to March 2021
description	Malaysia has experienced three waves of coronavirus disease 2019 (COVID-19) as of March 31, 2021. We studied the associated molecular epidemiology and SARS-CoV-2 seroprevalence during the third wave. We obtained 60 whole-genome SARS-CoV-2 sequences between October 2020 and January 2021 in Kuala Lumpur/Selangor and analyzed 989 available Malaysian sequences. We tested 653 residual serum samples collected between December 2020 to April 2021 for anti-SARS-CoV-2 total antibodies, as a proxy for population immunity. The first wave (January 2020) comprised sporadic imported cases from China of early Pango lineages A and B. The second wave (March-June 2020) was associated with lineage B.6. The ongoing third wave (from September 2020) was propagated by a state election in Sabah. It is due to lineage B.1.524 viruses containing spike mutations D614G and A701V. Lineages B.1.459, B.1.470, and B.1.466.2 were likely imported from the region and confined to Sarawak state. Direct age-standardized seroprevalence in Kuala Lumpur/Selangor was 3.0%. The second and third waves were driven by super-spreading events and different circulating lineages. Malaysia is highly susceptible to further waves, especially as alpha (B.1.1.7) and beta (B.1.351) variants of concern were first detected in December 2020/January 2021. Increased genomic surveillance is critical.
format	Article
author	Sam, I-Ching Chong, Yoong Min Abdullah, Azwani Fu, Jolene Yin Ling Hasan, M. Shahnaz Jamaluddin, Fadhil Hadi Kamarulzaman, Adeeba Lim, Koo Koon Nor, Mohd Afiq Mohd Pang, Yong Kek Ponnampalavanar, Sasheela Shahib, Muhammad Fadzil Omar, Sharifah Faridah Syed Chan, Jonathan Chia Jui Perera, David Chan, Yoke Fun
author_facet	Sam, I-Ching Chong, Yoong Min Abdullah, Azwani Fu, Jolene Yin Ling Hasan, M. Shahnaz Jamaluddin, Fadhil Hadi Kamarulzaman, Adeeba Lim, Koo Koon Nor, Mohd Afiq Mohd Pang, Yong Kek Ponnampalavanar, Sasheela Shahib, Muhammad Fadzil Omar, Sharifah Faridah Syed Chan, Jonathan Chia Jui Perera, David Chan, Yoke Fun
author_sort	Sam, I-Ching
title	Changing predominant SARS-CoV-2 lineages drives successive COVID-19 waves in Malaysia, February 2020 to March 2021
title_short	Changing predominant SARS-CoV-2 lineages drives successive COVID-19 waves in Malaysia, February 2020 to March 2021
title_full	Changing predominant SARS-CoV-2 lineages drives successive COVID-19 waves in Malaysia, February 2020 to March 2021
title_fullStr	Changing predominant SARS-CoV-2 lineages drives successive COVID-19 waves in Malaysia, February 2020 to March 2021
title_full_unstemmed	Changing predominant SARS-CoV-2 lineages drives successive COVID-19 waves in Malaysia, February 2020 to March 2021
title_sort	changing predominant sars-cov-2 lineages drives successive covid-19 waves in malaysia, february 2020 to march 2021
publisher	Wiley
publishDate	2022
url	http://eprints.um.edu.my/33694/
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score	13.211869

Changing predominant SARS-CoV-2 lineages drives successive COVID-19 waves in Malaysia, February 2020 to March 2021

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