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Genetic polymorphism of circumsporozoite protein (CSP) in Plasmodium malariae isolates from Malaysia

Information about Plasmodium malariae is scanty worldwide due to its ``benign'' nature and low infection rates. Consequently, studies on the genetic polymorphisms of P. malariae are lacking. Here, we report genetic polymorphisms of 28 P. malariae circumsporozoite protein (Pmcsp) isolates f...

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Main Authors: Phang, Wei Kit, Bukhari, Fatma Diyana Mohd, Zen, Lee Phone Youth, Jaimin, Joel Judson, Dony, Jiloris Julian Frederick, Lau, Yee Ling
Format: Article
Published: Elsevier 2022
Subjects:
QR Microbiology
Diseases, treatment, etc
Online Access:http://eprints.um.edu.my/33685/
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spelling my.um.eprints.336852022-07-20T04:38:40Z http://eprints.um.edu.my/33685/ Genetic polymorphism of circumsporozoite protein (CSP) in Plasmodium malariae isolates from Malaysia Phang, Wei Kit Bukhari, Fatma Diyana Mohd Zen, Lee Phone Youth Jaimin, Joel Judson Dony, Jiloris Julian Frederick Lau, Yee Ling QR Microbiology Diseases, treatment, etc Information about Plasmodium malariae is scanty worldwide due to its ``benign'' nature and low infection rates. Consequently, studies on the genetic polymorphisms of P. malariae are lacking. Here, we report genetic polymorphisms of 28 P. malariae circumsporozoite protein (Pmcsp) isolates from Malaysia which were compared with those in other regions in Asia as well as those from Africa. Phylogenetic analysis revealed that most Malaysian P. malariae isolates clustered together but independently from other Asian isolates. Low nucleotide diversity was observed in Pmcsp non-repeat regions in contrast to high nucleotide diversity observed in non-repeat regions of Plasmodium knowlesi CSP gene, the current major cause of malaria in Malaysia. This study contributes to the characterisation of naturally occurring polymorphisms in the P. malariae CSP gene. Elsevier 2022-04 Article PeerReviewed Phang, Wei Kit and Bukhari, Fatma Diyana Mohd and Zen, Lee Phone Youth and Jaimin, Joel Judson and Dony, Jiloris Julian Frederick and Lau, Yee Ling (2022) Genetic polymorphism of circumsporozoite protein (CSP) in Plasmodium malariae isolates from Malaysia. Parasitology International, 87. ISSN 1383-5769, DOI https://doi.org/10.1016/j.parint.2021.102519 <https://doi.org/10.1016/j.parint.2021.102519>. 10.1016/j.parint.2021.102519
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QR Microbiology
Diseases, treatment, etc
spellingShingle QR Microbiology
Diseases, treatment, etc
Phang, Wei Kit
Bukhari, Fatma Diyana Mohd
Zen, Lee Phone Youth
Jaimin, Joel Judson
Dony, Jiloris Julian Frederick
Lau, Yee Ling
Genetic polymorphism of circumsporozoite protein (CSP) in Plasmodium malariae isolates from Malaysia
description Information about Plasmodium malariae is scanty worldwide due to its ``benign'' nature and low infection rates. Consequently, studies on the genetic polymorphisms of P. malariae are lacking. Here, we report genetic polymorphisms of 28 P. malariae circumsporozoite protein (Pmcsp) isolates from Malaysia which were compared with those in other regions in Asia as well as those from Africa. Phylogenetic analysis revealed that most Malaysian P. malariae isolates clustered together but independently from other Asian isolates. Low nucleotide diversity was observed in Pmcsp non-repeat regions in contrast to high nucleotide diversity observed in non-repeat regions of Plasmodium knowlesi CSP gene, the current major cause of malaria in Malaysia. This study contributes to the characterisation of naturally occurring polymorphisms in the P. malariae CSP gene.
format Article
author Phang, Wei Kit
Bukhari, Fatma Diyana Mohd
Zen, Lee Phone Youth
Jaimin, Joel Judson
Dony, Jiloris Julian Frederick
Lau, Yee Ling
author_facet Phang, Wei Kit
Bukhari, Fatma Diyana Mohd
Zen, Lee Phone Youth
Jaimin, Joel Judson
Dony, Jiloris Julian Frederick
Lau, Yee Ling
author_sort Phang, Wei Kit
title Genetic polymorphism of circumsporozoite protein (CSP) in Plasmodium malariae isolates from Malaysia
title_short Genetic polymorphism of circumsporozoite protein (CSP) in Plasmodium malariae isolates from Malaysia
title_full Genetic polymorphism of circumsporozoite protein (CSP) in Plasmodium malariae isolates from Malaysia
title_fullStr Genetic polymorphism of circumsporozoite protein (CSP) in Plasmodium malariae isolates from Malaysia
title_full_unstemmed Genetic polymorphism of circumsporozoite protein (CSP) in Plasmodium malariae isolates from Malaysia
title_sort genetic polymorphism of circumsporozoite protein (csp) in plasmodium malariae isolates from malaysia
publisher Elsevier
publishDate 2022
url http://eprints.um.edu.my/33685/
_version_ 1739828470315220992
score 13.211869

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