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Contribution of viral respiratory infections to dengue-like illness presentation at a community clinic in southern Malaysia

This study explored the contribution of viral respiratory infections (VRIs) in dengue-like illness (DLI) patients and their distinguishing clinicolaboratory parameters. Two hundred DLI patients were prospectively recruited (July 1- October 1, 2019) from a community clinic in Southern Malaysia. Patie...

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Main Authors: Dhanoa, Amreeta, Ngim, Chin Fang, Mohd Yunos, Nor'azim, Husain, Syed M. Tupur, Pong, Lian Yih, Ismail, Wan Fadhilah Wan, Hontz, Robert D., Hassan, Sharifah Syed
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Published: Amer Soc Trop Med & Hygiene 2022
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RC Internal medicine
Online Access:http://eprints.um.edu.my/33538/
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spelling my.um.eprints.335382022-08-15T01:19:15Z http://eprints.um.edu.my/33538/ Contribution of viral respiratory infections to dengue-like illness presentation at a community clinic in southern Malaysia Dhanoa, Amreeta Ngim, Chin Fang Mohd Yunos, Nor'azim Husain, Syed M. Tupur Pong, Lian Yih Ismail, Wan Fadhilah Wan Hontz, Robert D. Hassan, Sharifah Syed RC Internal medicine This study explored the contribution of viral respiratory infections (VRIs) in dengue-like illness (DLI) patients and their distinguishing clinicolaboratory parameters. Two hundred DLI patients were prospectively recruited (July 1- October 1, 2019) from a community clinic in Southern Malaysia. Patients >_ 18 years with acute fever and fulfilling the WHO criteria of probable dengue were recruited. They underwent blood testing: blood counts, rapid dengue tests (nonstructural antigen-1/IgM) and polymerase chain reaction (PCR) for dengue, Zika, chikungunya, and Leptospira. Nasopharyngeal swabs (NPSs) were collected for FilmArrayVR RP2plus testing. From the 200 NPSs, 58 respiratory viruses (RVs) were detected in 54 patients. Of the 96 dengue-confirmed cases, 86 had dengue mono-infection, and 10 were coinfected with RVs. Of the 104 nondengue, 44 were RV positive and 4 Leptospira positive. Zika and chikungunya virus were not detected. Overall, the etiological diagnosis was confirmed for 72% of patients. Clinicolaboratory parameters were compared between dengue mono-infection and VRI mono-infection. Patients with coinfections were excluded. Multiple logistic regression showed that recent household/neighborhood history of dengue (adjusted odds ratio aOR]: 5.9, 95% CI = 1.7-20.7), leukopenia (aOR: 12.5, 95% CI = 2.6-61.4) and thrombocytopenia (aOR: 5.5, 95% CI = 1.3-23.0) predicted dengue. Inversely, rhinorrhoea (aOR: 0.1, 95% CI = 0.01-0.3) and cough (aOR: 0.3, 95% CI = 0.1-0.9) favored VRI. Thus, VRIs comprise many infections diagnosed initially as DLIs. Early clinicolaboratory parameters can guide physicians screen patients for further testing. Amer Soc Trop Med & Hygiene 2022-01 Article PeerReviewed Dhanoa, Amreeta and Ngim, Chin Fang and Mohd Yunos, Nor'azim and Husain, Syed M. Tupur and Pong, Lian Yih and Ismail, Wan Fadhilah Wan and Hontz, Robert D. and Hassan, Sharifah Syed (2022) Contribution of viral respiratory infections to dengue-like illness presentation at a community clinic in southern Malaysia. American Journal of Tropical Medicine and Hygiene, 106 (1). pp. 187-191. ISSN 0002-9637, DOI https://doi.org/10.4269/ajtmh.21-0648 <https://doi.org/10.4269/ajtmh.21-0648>. 10.4269/ajtmh.21-0648
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic RC Internal medicine
spellingShingle RC Internal medicine
Dhanoa, Amreeta
Ngim, Chin Fang
Mohd Yunos, Nor'azim
Husain, Syed M. Tupur
Pong, Lian Yih
Ismail, Wan Fadhilah Wan
Hontz, Robert D.
Hassan, Sharifah Syed
Contribution of viral respiratory infections to dengue-like illness presentation at a community clinic in southern Malaysia
description This study explored the contribution of viral respiratory infections (VRIs) in dengue-like illness (DLI) patients and their distinguishing clinicolaboratory parameters. Two hundred DLI patients were prospectively recruited (July 1- October 1, 2019) from a community clinic in Southern Malaysia. Patients >_ 18 years with acute fever and fulfilling the WHO criteria of probable dengue were recruited. They underwent blood testing: blood counts, rapid dengue tests (nonstructural antigen-1/IgM) and polymerase chain reaction (PCR) for dengue, Zika, chikungunya, and Leptospira. Nasopharyngeal swabs (NPSs) were collected for FilmArrayVR RP2plus testing. From the 200 NPSs, 58 respiratory viruses (RVs) were detected in 54 patients. Of the 96 dengue-confirmed cases, 86 had dengue mono-infection, and 10 were coinfected with RVs. Of the 104 nondengue, 44 were RV positive and 4 Leptospira positive. Zika and chikungunya virus were not detected. Overall, the etiological diagnosis was confirmed for 72% of patients. Clinicolaboratory parameters were compared between dengue mono-infection and VRI mono-infection. Patients with coinfections were excluded. Multiple logistic regression showed that recent household/neighborhood history of dengue (adjusted odds ratio aOR]: 5.9, 95% CI = 1.7-20.7), leukopenia (aOR: 12.5, 95% CI = 2.6-61.4) and thrombocytopenia (aOR: 5.5, 95% CI = 1.3-23.0) predicted dengue. Inversely, rhinorrhoea (aOR: 0.1, 95% CI = 0.01-0.3) and cough (aOR: 0.3, 95% CI = 0.1-0.9) favored VRI. Thus, VRIs comprise many infections diagnosed initially as DLIs. Early clinicolaboratory parameters can guide physicians screen patients for further testing.
format Article
author Dhanoa, Amreeta
Ngim, Chin Fang
Mohd Yunos, Nor'azim
Husain, Syed M. Tupur
Pong, Lian Yih
Ismail, Wan Fadhilah Wan
Hontz, Robert D.
Hassan, Sharifah Syed
author_facet Dhanoa, Amreeta
Ngim, Chin Fang
Mohd Yunos, Nor'azim
Husain, Syed M. Tupur
Pong, Lian Yih
Ismail, Wan Fadhilah Wan
Hontz, Robert D.
Hassan, Sharifah Syed
author_sort Dhanoa, Amreeta
title Contribution of viral respiratory infections to dengue-like illness presentation at a community clinic in southern Malaysia
title_short Contribution of viral respiratory infections to dengue-like illness presentation at a community clinic in southern Malaysia
title_full Contribution of viral respiratory infections to dengue-like illness presentation at a community clinic in southern Malaysia
title_fullStr Contribution of viral respiratory infections to dengue-like illness presentation at a community clinic in southern Malaysia
title_full_unstemmed Contribution of viral respiratory infections to dengue-like illness presentation at a community clinic in southern Malaysia
title_sort contribution of viral respiratory infections to dengue-like illness presentation at a community clinic in southern malaysia
publisher Amer Soc Trop Med & Hygiene
publishDate 2022
url http://eprints.um.edu.my/33538/
_version_ 1744649156865032192
score 13.211869

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