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Nanocrystalline hydroxyapatite prepared at different precursor concentrations: thermal stability, morphology and in vitro cellular response

Hydroxyapatite is widely used for the reconstruction of defective bones due to its similarity with the composition of bone mineral. In this research, nanocrystalline hydroxyapatite (HA) was synthesised using calcium hydroxide and phosphoric acid as starting precursors. Different concentrations of th...

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Main Authors: Thi, Bang Le, Long, Bui Duc, Trung, Trinh Van, Thanh, Nguyen T Van, Ramesh, S.
Format: Article
Published: Univ Chemistry & Technology, Prague 2022
Subjects:
TJ Mechanical engineering and machinery
Online Access:http://eprints.um.edu.my/33523/
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spelling my.um.eprints.335232022-07-22T05:50:18Z http://eprints.um.edu.my/33523/ Nanocrystalline hydroxyapatite prepared at different precursor concentrations: thermal stability, morphology and in vitro cellular response Thi, Bang Le Long, Bui Duc Trung, Trinh Van Thanh, Nguyen T Van Ramesh, S. TJ Mechanical engineering and machinery Hydroxyapatite is widely used for the reconstruction of defective bones due to its similarity with the composition of bone mineral. In this research, nanocrystalline hydroxyapatite (HA) was synthesised using calcium hydroxide and phosphoric acid as starting precursors. Different concentrations of the reactants, viz. 0.5, 1.0, 1.5 and 2.0 mol center dot L-1, were considered to investigate their effect on the thermal stability and morphology of the synthesised HA. The results showed that the synthesised HA exhibited rod-like shaped particles having sizes in the range of 73.4 to 114.5 nm in length and 14.9 to 20.7 nm in width. The HA produced at the reactant concentration of 0.5 and 1.0 mol center dot L-1 was thermally stable up to 1200 degrees C and did not exhibit any secondary phase. However, the HA prepared at the 1.5 mol center dot L-1 concentration decomposed into tricalcium phosphate at 1000 degrees C while the HA prepared at 2.0 mol center dot L-1 decomposed at 1200 degrees C. It was also found that the size of the particles increased with increasing reactant concentrations. The HA produced from the reactant concentration of 1.0 mol center dot L-1 was found to be optimum in terms of the powder characteristics and the in vitro cell studies indicated that osteoblast cells proliferated well on the synthesised HA, thus confirming the biocompatible nature of the produced bioceramic. Univ Chemistry & Technology, Prague 2022 Article PeerReviewed Thi, Bang Le and Long, Bui Duc and Trung, Trinh Van and Thanh, Nguyen T Van and Ramesh, S. (2022) Nanocrystalline hydroxyapatite prepared at different precursor concentrations: thermal stability, morphology and in vitro cellular response. Ceramics-Silik�ty, 66 (1). pp. 19-27. ISSN 0862-5468, DOI https://doi.org/10.13168/cs.2021.0048 <https://doi.org/10.13168/cs.2021.0048>. 10.13168/cs.2021.0048
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic TJ Mechanical engineering and machinery
spellingShingle TJ Mechanical engineering and machinery
Thi, Bang Le
Long, Bui Duc
Trung, Trinh Van
Thanh, Nguyen T Van
Ramesh, S.
Nanocrystalline hydroxyapatite prepared at different precursor concentrations: thermal stability, morphology and in vitro cellular response
description Hydroxyapatite is widely used for the reconstruction of defective bones due to its similarity with the composition of bone mineral. In this research, nanocrystalline hydroxyapatite (HA) was synthesised using calcium hydroxide and phosphoric acid as starting precursors. Different concentrations of the reactants, viz. 0.5, 1.0, 1.5 and 2.0 mol center dot L-1, were considered to investigate their effect on the thermal stability and morphology of the synthesised HA. The results showed that the synthesised HA exhibited rod-like shaped particles having sizes in the range of 73.4 to 114.5 nm in length and 14.9 to 20.7 nm in width. The HA produced at the reactant concentration of 0.5 and 1.0 mol center dot L-1 was thermally stable up to 1200 degrees C and did not exhibit any secondary phase. However, the HA prepared at the 1.5 mol center dot L-1 concentration decomposed into tricalcium phosphate at 1000 degrees C while the HA prepared at 2.0 mol center dot L-1 decomposed at 1200 degrees C. It was also found that the size of the particles increased with increasing reactant concentrations. The HA produced from the reactant concentration of 1.0 mol center dot L-1 was found to be optimum in terms of the powder characteristics and the in vitro cell studies indicated that osteoblast cells proliferated well on the synthesised HA, thus confirming the biocompatible nature of the produced bioceramic.
format Article
author Thi, Bang Le
Long, Bui Duc
Trung, Trinh Van
Thanh, Nguyen T Van
Ramesh, S.
author_facet Thi, Bang Le
Long, Bui Duc
Trung, Trinh Van
Thanh, Nguyen T Van
Ramesh, S.
author_sort Thi, Bang Le
title Nanocrystalline hydroxyapatite prepared at different precursor concentrations: thermal stability, morphology and in vitro cellular response
title_short Nanocrystalline hydroxyapatite prepared at different precursor concentrations: thermal stability, morphology and in vitro cellular response
title_full Nanocrystalline hydroxyapatite prepared at different precursor concentrations: thermal stability, morphology and in vitro cellular response
title_fullStr Nanocrystalline hydroxyapatite prepared at different precursor concentrations: thermal stability, morphology and in vitro cellular response
title_full_unstemmed Nanocrystalline hydroxyapatite prepared at different precursor concentrations: thermal stability, morphology and in vitro cellular response
title_sort nanocrystalline hydroxyapatite prepared at different precursor concentrations: thermal stability, morphology and in vitro cellular response
publisher Univ Chemistry & Technology, Prague
publishDate 2022
url http://eprints.um.edu.my/33523/
_version_ 1739828455439073280
score 13.211869

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