Staff View: Enhanced curcumin loaded nanocellulose: A possible inhalable nanotherapeutic to treat COVID-19

Enhanced curcumin loaded nanocellulose: A possible inhalable nanotherapeutic to treat COVID-19

Nanocellulose/polyvinyl alcohol/cur- cumin (CNC/PVA/curcumin) nanoparticles with enhanced drug loading properties were developed by the dispersion of nanocellulose in curcumin/polyvinyl alcohol aqueous medium. Due to the physical and chemical nature of sulphuric acid hydrolyzed nanocellulose and the...

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Main Authors:	Gunathilake, Thennakoon M. Sampath U., Ching, Yern Chee, Uyama, Hiroshi, Hai, Nguyen Dai, Chuah, Cheng Hock
Format:	Article
Published:	Springer 2022
Subjects:	Q Science (General)
Online Access:	http://eprints.um.edu.my/33504/
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spelling	my.um.eprints.335042022-07-29T08:20:14Z http://eprints.um.edu.my/33504/ Enhanced curcumin loaded nanocellulose: A possible inhalable nanotherapeutic to treat COVID-19 Gunathilake, Thennakoon M. Sampath U. Ching, Yern Chee Uyama, Hiroshi Hai, Nguyen Dai Chuah, Cheng Hock Q Science (General) Nanocellulose/polyvinyl alcohol/cur- cumin (CNC/PVA/curcumin) nanoparticles with enhanced drug loading properties were developed by the dispersion of nanocellulose in curcumin/polyvinyl alcohol aqueous medium. Due to the physical and chemical nature of sulphuric acid hydrolyzed nanocellulose and the antiviral properties of curcumin, the possibility of using these nanoparticles as an inhalable nanotherapeutic for the treatment of coronavirus disease 2019 (COVID-19) is discussed. The adsorption of curcumin and PVA into nanocellulose, and the presence of anionic sulphate groups, which is important for the interaction with viral glycoproteins were confirmed by Fourier transform infrared (FTIR) spectroscopy. FESEM images showed that the diameter of nanocellulose ranged from 50 to 100 nm, which is closer to the diameter (60-140 nm) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The solubility of poorly water-soluble curcumin was increased from 40.58 +/- 1.42 to 313.61 +/- 1.05 mg/L with increasing the PVA concentration from 0.05 to 0.8% (w/v) in aqueous medium. This is a significant increase in the solubility compared to curcumin's solubility in carboxymethyl cellulose medium in our previous study. The drug loading capacity increased by 22-fold with the addition of 0.8% PVA to the nanocellulose dispersed curcumin solution. The highest drug release increased from 1.25 +/- 0.15 mg/L to 17.11 +/- 0.22 mg/L with increasing the PVA concentration from 0 to 0.8% in the drug-loaded medium. Future studies of this material will be based on the antiviral efficacy against SARS-CoV-2 and cell cytotoxicity studies. Due to the particulate nature, morphology and size of SARS-CoV-2, nanoparticle-based strategies offer a strong approach to tackling this virus. Hence, we believe that the enhanced loading of curcumin in nanocellulose will provide a promising nano-based solution for the treatment of COVID-19. GRAPHICS] . Springer 2022-02 Article PeerReviewed Gunathilake, Thennakoon M. Sampath U. and Ching, Yern Chee and Uyama, Hiroshi and Hai, Nguyen Dai and Chuah, Cheng Hock (2022) Enhanced curcumin loaded nanocellulose: A possible inhalable nanotherapeutic to treat COVID-19. Cellulose, 29 (3). pp. 1821-1840. ISSN 0969-0239, DOI https://doi.org/10.1007/s10570-021-04391-8 <https://doi.org/10.1007/s10570-021-04391-8>. 10.1007/s10570-021-04391-8
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	Q Science (General)
spellingShingle	Q Science (General) Gunathilake, Thennakoon M. Sampath U. Ching, Yern Chee Uyama, Hiroshi Hai, Nguyen Dai Chuah, Cheng Hock Enhanced curcumin loaded nanocellulose: A possible inhalable nanotherapeutic to treat COVID-19
description	Nanocellulose/polyvinyl alcohol/cur- cumin (CNC/PVA/curcumin) nanoparticles with enhanced drug loading properties were developed by the dispersion of nanocellulose in curcumin/polyvinyl alcohol aqueous medium. Due to the physical and chemical nature of sulphuric acid hydrolyzed nanocellulose and the antiviral properties of curcumin, the possibility of using these nanoparticles as an inhalable nanotherapeutic for the treatment of coronavirus disease 2019 (COVID-19) is discussed. The adsorption of curcumin and PVA into nanocellulose, and the presence of anionic sulphate groups, which is important for the interaction with viral glycoproteins were confirmed by Fourier transform infrared (FTIR) spectroscopy. FESEM images showed that the diameter of nanocellulose ranged from 50 to 100 nm, which is closer to the diameter (60-140 nm) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The solubility of poorly water-soluble curcumin was increased from 40.58 +/- 1.42 to 313.61 +/- 1.05 mg/L with increasing the PVA concentration from 0.05 to 0.8% (w/v) in aqueous medium. This is a significant increase in the solubility compared to curcumin's solubility in carboxymethyl cellulose medium in our previous study. The drug loading capacity increased by 22-fold with the addition of 0.8% PVA to the nanocellulose dispersed curcumin solution. The highest drug release increased from 1.25 +/- 0.15 mg/L to 17.11 +/- 0.22 mg/L with increasing the PVA concentration from 0 to 0.8% in the drug-loaded medium. Future studies of this material will be based on the antiviral efficacy against SARS-CoV-2 and cell cytotoxicity studies. Due to the particulate nature, morphology and size of SARS-CoV-2, nanoparticle-based strategies offer a strong approach to tackling this virus. Hence, we believe that the enhanced loading of curcumin in nanocellulose will provide a promising nano-based solution for the treatment of COVID-19. GRAPHICS] .
format	Article
author	Gunathilake, Thennakoon M. Sampath U. Ching, Yern Chee Uyama, Hiroshi Hai, Nguyen Dai Chuah, Cheng Hock
author_facet	Gunathilake, Thennakoon M. Sampath U. Ching, Yern Chee Uyama, Hiroshi Hai, Nguyen Dai Chuah, Cheng Hock
author_sort	Gunathilake, Thennakoon M. Sampath U.
title	Enhanced curcumin loaded nanocellulose: A possible inhalable nanotherapeutic to treat COVID-19
title_short	Enhanced curcumin loaded nanocellulose: A possible inhalable nanotherapeutic to treat COVID-19
title_full	Enhanced curcumin loaded nanocellulose: A possible inhalable nanotherapeutic to treat COVID-19
title_fullStr	Enhanced curcumin loaded nanocellulose: A possible inhalable nanotherapeutic to treat COVID-19
title_full_unstemmed	Enhanced curcumin loaded nanocellulose: A possible inhalable nanotherapeutic to treat COVID-19
title_sort	enhanced curcumin loaded nanocellulose: a possible inhalable nanotherapeutic to treat covid-19
publisher	Springer
publishDate	2022
url	http://eprints.um.edu.my/33504/
_version_	1740826037168635904
score	13.211869

Enhanced curcumin loaded nanocellulose: A possible inhalable nanotherapeutic to treat COVID-19

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