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The effect of nanoparticle-incorporated natural-based biomaterials towards cells on activated pathways: A systematic review

The advancement of natural-based biomaterials in providing a carrier has revealed a wide range of benefits in the biomedical sciences, particularly in wound healing, tissue engineering and regenerative medicine. Incorporating nanoparticles within polymer composites has been reported to enhance scaff...

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Main Authors: Fadilah, Nur Izzah Md, Isa, Isma Liza Mohd, Zaman, Wan Safwani Wan Kamarul, Tabata, Yasuhiko, Fauzi, Mh Busra
Format: Article
Published: MDPI 2022
Subjects:
Q Science (General)
Online Access:http://eprints.um.edu.my/33403/
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spelling my.um.eprints.334032022-08-05T03:59:51Z http://eprints.um.edu.my/33403/ The effect of nanoparticle-incorporated natural-based biomaterials towards cells on activated pathways: A systematic review Fadilah, Nur Izzah Md Isa, Isma Liza Mohd Zaman, Wan Safwani Wan Kamarul Tabata, Yasuhiko Fauzi, Mh Busra Q Science (General) The advancement of natural-based biomaterials in providing a carrier has revealed a wide range of benefits in the biomedical sciences, particularly in wound healing, tissue engineering and regenerative medicine. Incorporating nanoparticles within polymer composites has been reported to enhance scaffolding performance, cellular interactions and their physico-chemical and biological properties in comparison to analogue composites without nanoparticles. This review summarized the current knowledge of nanoparticles incorporated into natural-based biomaterials with effects on their cellular interactions in wound healing. Although the mechanisms of wound healing and the function of specific cells in wound repair have been partially described, many of the underlying signaling pathways remain unknown. We also reviewed the current understanding and new insights into the wingless/integrated (Wnt)/beta-catenin pathway and other signaling pathways of transforming growth factor beta (TGF-beta), Notch, and Sonic hedgehog during wound healing. The findings demonstrated that most of the studies reported positive outcomes of biomaterial scaffolds incorporated with nanoparticles on cell attachment, viability, proliferation, and migration. Combining therapies consisting of nanoparticles and biomaterials could be promising for future therapies and better outcomes in tissue engineering and regenerative medicine. MDPI 2022-02 Article PeerReviewed Fadilah, Nur Izzah Md and Isa, Isma Liza Mohd and Zaman, Wan Safwani Wan Kamarul and Tabata, Yasuhiko and Fauzi, Mh Busra (2022) The effect of nanoparticle-incorporated natural-based biomaterials towards cells on activated pathways: A systematic review. Polymers, 14 (3). ISSN 2073-4360, DOI https://doi.org/10.3390/polym14030476 <https://doi.org/10.3390/polym14030476>. 10.3390/polym14030476
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
spellingShingle Q Science (General)
Fadilah, Nur Izzah Md
Isa, Isma Liza Mohd
Zaman, Wan Safwani Wan Kamarul
Tabata, Yasuhiko
Fauzi, Mh Busra
The effect of nanoparticle-incorporated natural-based biomaterials towards cells on activated pathways: A systematic review
description The advancement of natural-based biomaterials in providing a carrier has revealed a wide range of benefits in the biomedical sciences, particularly in wound healing, tissue engineering and regenerative medicine. Incorporating nanoparticles within polymer composites has been reported to enhance scaffolding performance, cellular interactions and their physico-chemical and biological properties in comparison to analogue composites without nanoparticles. This review summarized the current knowledge of nanoparticles incorporated into natural-based biomaterials with effects on their cellular interactions in wound healing. Although the mechanisms of wound healing and the function of specific cells in wound repair have been partially described, many of the underlying signaling pathways remain unknown. We also reviewed the current understanding and new insights into the wingless/integrated (Wnt)/beta-catenin pathway and other signaling pathways of transforming growth factor beta (TGF-beta), Notch, and Sonic hedgehog during wound healing. The findings demonstrated that most of the studies reported positive outcomes of biomaterial scaffolds incorporated with nanoparticles on cell attachment, viability, proliferation, and migration. Combining therapies consisting of nanoparticles and biomaterials could be promising for future therapies and better outcomes in tissue engineering and regenerative medicine.
format Article
author Fadilah, Nur Izzah Md
Isa, Isma Liza Mohd
Zaman, Wan Safwani Wan Kamarul
Tabata, Yasuhiko
Fauzi, Mh Busra
author_facet Fadilah, Nur Izzah Md
Isa, Isma Liza Mohd
Zaman, Wan Safwani Wan Kamarul
Tabata, Yasuhiko
Fauzi, Mh Busra
author_sort Fadilah, Nur Izzah Md
title The effect of nanoparticle-incorporated natural-based biomaterials towards cells on activated pathways: A systematic review
title_short The effect of nanoparticle-incorporated natural-based biomaterials towards cells on activated pathways: A systematic review
title_full The effect of nanoparticle-incorporated natural-based biomaterials towards cells on activated pathways: A systematic review
title_fullStr The effect of nanoparticle-incorporated natural-based biomaterials towards cells on activated pathways: A systematic review
title_full_unstemmed The effect of nanoparticle-incorporated natural-based biomaterials towards cells on activated pathways: A systematic review
title_sort effect of nanoparticle-incorporated natural-based biomaterials towards cells on activated pathways: a systematic review
publisher MDPI
publishDate 2022
url http://eprints.um.edu.my/33403/
_version_ 1740826028336480256
score 13.211869

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