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An overview of metal-free sustainable nitrogen-based catalytic knoevenagel condensation reaction

Knoevenagel condensation reaction counts as a vital condensation in organic chemistry due to the synthesis of valuable intermediates, heterocycles, and fine chemicals from commercially available reactants through forming new C = C bonds between an aldehyde or ketone and active methylene compounds. T...

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Main Authors: Johari, Suzaimi, Johan, Mohd Rafie, Khaligh, Nader Ghaffari
Format: Article
Published: Royal Soc Chemistry 2022
Subjects:
QD Chemistry
Online Access:http://eprints.um.edu.my/33350/
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spelling my.um.eprints.333502022-08-08T00:20:09Z http://eprints.um.edu.my/33350/ An overview of metal-free sustainable nitrogen-based catalytic knoevenagel condensation reaction Johari, Suzaimi Johan, Mohd Rafie Khaligh, Nader Ghaffari QD Chemistry Knoevenagel condensation reaction counts as a vital condensation in organic chemistry due to the synthesis of valuable intermediates, heterocycles, and fine chemicals from commercially available reactants through forming new C = C bonds between an aldehyde or ketone and active methylene compounds. Therefore, the catalytic Knoevenagel condensation reaction has continuously received significant interest in different aspects, i.e., investigating the catalytic efficiency of new heterogeneous and homogeneous catalysts. Furthermore, metal-free catalysis has recently attracted considerable attention because of environmental concerns. This review summarizes the most recent studies on utilizing metal-free nitrogen-based catalysts in the Knoevenagel condensation reaction, including organocatalysts, polymers, ionic liquids, and bio- and carbon-based catalysts. The substrate scope, the optimal reaction conditions, selectivity, the desired product yield, merits, and limitations of each method are discussed. In addition, the recyclability, biocompatibility, and biodegradability of catalysts are reported. This review also covers the approaches that influence the selectivity of the Knoevenagel products. Royal Soc Chemistry 2022-03-16 Article PeerReviewed Johari, Suzaimi and Johan, Mohd Rafie and Khaligh, Nader Ghaffari (2022) An overview of metal-free sustainable nitrogen-based catalytic knoevenagel condensation reaction. Organic & Biomolecular Chemistry, 20 (11). pp. 2164-2186. ISSN 1477-0520, DOI https://doi.org/10.1039/d2ob00135g <https://doi.org/10.1039/d2ob00135g>. 10.1039/d2ob00135g
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
spellingShingle QD Chemistry
Johari, Suzaimi
Johan, Mohd Rafie
Khaligh, Nader Ghaffari
An overview of metal-free sustainable nitrogen-based catalytic knoevenagel condensation reaction
description Knoevenagel condensation reaction counts as a vital condensation in organic chemistry due to the synthesis of valuable intermediates, heterocycles, and fine chemicals from commercially available reactants through forming new C = C bonds between an aldehyde or ketone and active methylene compounds. Therefore, the catalytic Knoevenagel condensation reaction has continuously received significant interest in different aspects, i.e., investigating the catalytic efficiency of new heterogeneous and homogeneous catalysts. Furthermore, metal-free catalysis has recently attracted considerable attention because of environmental concerns. This review summarizes the most recent studies on utilizing metal-free nitrogen-based catalysts in the Knoevenagel condensation reaction, including organocatalysts, polymers, ionic liquids, and bio- and carbon-based catalysts. The substrate scope, the optimal reaction conditions, selectivity, the desired product yield, merits, and limitations of each method are discussed. In addition, the recyclability, biocompatibility, and biodegradability of catalysts are reported. This review also covers the approaches that influence the selectivity of the Knoevenagel products.
format Article
author Johari, Suzaimi
Johan, Mohd Rafie
Khaligh, Nader Ghaffari
author_facet Johari, Suzaimi
Johan, Mohd Rafie
Khaligh, Nader Ghaffari
author_sort Johari, Suzaimi
title An overview of metal-free sustainable nitrogen-based catalytic knoevenagel condensation reaction
title_short An overview of metal-free sustainable nitrogen-based catalytic knoevenagel condensation reaction
title_full An overview of metal-free sustainable nitrogen-based catalytic knoevenagel condensation reaction
title_fullStr An overview of metal-free sustainable nitrogen-based catalytic knoevenagel condensation reaction
title_full_unstemmed An overview of metal-free sustainable nitrogen-based catalytic knoevenagel condensation reaction
title_sort overview of metal-free sustainable nitrogen-based catalytic knoevenagel condensation reaction
publisher Royal Soc Chemistry
publishDate 2022
url http://eprints.um.edu.my/33350/
_version_ 1740826023888420864
score 13.211869

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