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Phytochemicals of six selected herbal plants and their inhibitory activities towards free radicals and glycation

In type 2 diabetes mellitus patients, hyperglycaemia speed up the production of advanced glycation end products (AGEs), leading to oxidative stress and various diabetic complications. In order to identify natural products with potential antioxidant and antiglycative properties, six herbal plants, na...

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Main Authors:	Wong, Chen Yuan, Leong, Kok Hoong, He, Xuemei, Zheng, Fengjing, Sun, Jian, Wang, Zhenxing, Heh, Choon Han, Kong, Kin Weng
Format:	Article
Published:	Elsevier 2022
Subjects:	TP Chemical technology TX Home economics
Online Access:	http://eprints.um.edu.my/32738/
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spelling	my.um.eprints.327382022-08-11T00:30:05Z http://eprints.um.edu.my/32738/ Phytochemicals of six selected herbal plants and their inhibitory activities towards free radicals and glycation Wong, Chen Yuan Leong, Kok Hoong He, Xuemei Zheng, Fengjing Sun, Jian Wang, Zhenxing Heh, Choon Han Kong, Kin Weng TP Chemical technology TX Home economics In type 2 diabetes mellitus patients, hyperglycaemia speed up the production of advanced glycation end products (AGEs), leading to oxidative stress and various diabetic complications. In order to identify natural products with potential antioxidant and antiglycative properties, six herbal plants, namely Musa acuminata (flower buds), Bletilla striata (rhizomes), Amomum villosum (dried nuts), Moghania philippinensis (roots), Minettia speciosa (rhizomes), and Spatholobus suberectus (stems) were assessed for their antioxidant and antiglycative properties. Among all the selected samples, both water and ethanolic extracts of S. suberectus possessed the highest phenolic, flavonoid and triterpenoid contents, ranging from three to six-fold higher than other plant extracts. In consistent with its phytochemical content, S. suberectus also showed the highest antioxidant activities which are comparable, if not higher than the known antioxidants, butylated hydroxytoluene, gallic acid, rutin, quercetin and ursolic acid. Similarly, S. suberectus also displayed the highest antiglycative activities among the six herbal plants measured by two glycation assays using bovine serum albumin-glucose and bovine serum albumin-methylglyoxal as model systems. HPLC-QTa-MS/MS analysis identified 48 polyphenols and 76 terpenoids, from the water and ethanolic extracts of S. suberectus, where 12 polyphenols and 9 terpenoids are common in both extracts. The results also suggested that S. suberectus contains compounds such as quercetin, luteolin, apigenin and saponin derivatives, which were reported to exert high antioxidant and antiglycative properties. The high antioxidant and antiglycative properties suggest the great potential of S. suberectus in preventing the formation of AGEs and oxidative stress seen in type 2 diabetes. Elsevier 2022-04 Article PeerReviewed Wong, Chen Yuan and Leong, Kok Hoong and He, Xuemei and Zheng, Fengjing and Sun, Jian and Wang, Zhenxing and Heh, Choon Han and Kong, Kin Weng (2022) Phytochemicals of six selected herbal plants and their inhibitory activities towards free radicals and glycation. Food Bioscience, 46. ISSN 2212-4292, DOI https://doi.org/10.1016/j.fbio.2022.101557 <https://doi.org/10.1016/j.fbio.2022.101557>. 10.1016/j.fbio.2022.101557
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	TP Chemical technology TX Home economics
spellingShingle	TP Chemical technology TX Home economics Wong, Chen Yuan Leong, Kok Hoong He, Xuemei Zheng, Fengjing Sun, Jian Wang, Zhenxing Heh, Choon Han Kong, Kin Weng Phytochemicals of six selected herbal plants and their inhibitory activities towards free radicals and glycation
description	In type 2 diabetes mellitus patients, hyperglycaemia speed up the production of advanced glycation end products (AGEs), leading to oxidative stress and various diabetic complications. In order to identify natural products with potential antioxidant and antiglycative properties, six herbal plants, namely Musa acuminata (flower buds), Bletilla striata (rhizomes), Amomum villosum (dried nuts), Moghania philippinensis (roots), Minettia speciosa (rhizomes), and Spatholobus suberectus (stems) were assessed for their antioxidant and antiglycative properties. Among all the selected samples, both water and ethanolic extracts of S. suberectus possessed the highest phenolic, flavonoid and triterpenoid contents, ranging from three to six-fold higher than other plant extracts. In consistent with its phytochemical content, S. suberectus also showed the highest antioxidant activities which are comparable, if not higher than the known antioxidants, butylated hydroxytoluene, gallic acid, rutin, quercetin and ursolic acid. Similarly, S. suberectus also displayed the highest antiglycative activities among the six herbal plants measured by two glycation assays using bovine serum albumin-glucose and bovine serum albumin-methylglyoxal as model systems. HPLC-QTa-MS/MS analysis identified 48 polyphenols and 76 terpenoids, from the water and ethanolic extracts of S. suberectus, where 12 polyphenols and 9 terpenoids are common in both extracts. The results also suggested that S. suberectus contains compounds such as quercetin, luteolin, apigenin and saponin derivatives, which were reported to exert high antioxidant and antiglycative properties. The high antioxidant and antiglycative properties suggest the great potential of S. suberectus in preventing the formation of AGEs and oxidative stress seen in type 2 diabetes.
format	Article
author	Wong, Chen Yuan Leong, Kok Hoong He, Xuemei Zheng, Fengjing Sun, Jian Wang, Zhenxing Heh, Choon Han Kong, Kin Weng
author_facet	Wong, Chen Yuan Leong, Kok Hoong He, Xuemei Zheng, Fengjing Sun, Jian Wang, Zhenxing Heh, Choon Han Kong, Kin Weng
author_sort	Wong, Chen Yuan
title	Phytochemicals of six selected herbal plants and their inhibitory activities towards free radicals and glycation
title_short	Phytochemicals of six selected herbal plants and their inhibitory activities towards free radicals and glycation
title_full	Phytochemicals of six selected herbal plants and their inhibitory activities towards free radicals and glycation
title_fullStr	Phytochemicals of six selected herbal plants and their inhibitory activities towards free radicals and glycation
title_full_unstemmed	Phytochemicals of six selected herbal plants and their inhibitory activities towards free radicals and glycation
title_sort	phytochemicals of six selected herbal plants and their inhibitory activities towards free radicals and glycation
publisher	Elsevier
publishDate	2022
url	http://eprints.um.edu.my/32738/
_version_	1744649148563456000
score	13.211869

Phytochemicals of six selected herbal plants and their inhibitory activities towards free radicals and glycation

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