Staff View: Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: A review

Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: A review

Bladder cancer is the fourth most common malignancy in males. It can present across the whole continuum of severity, from mild through well-differentiated disease to extremely malignant tumours with poor survival rates. As with other vital organ malignancies, proper clinical management involves accu...

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Main Authors:	Kanmalar, M., Abdul Sani, Siti Fairus, Kamri, Nur Izzahtul Nabilla B., Mohd Said, Nur Akmarina, Abd Jamil, Amirah Hajirah, Kuppusamy, S., Mun, Kien Seong, Bradley, D. A.
Format:	Article
Published:	BMC 2022
Subjects:	QD Chemistry QH301 Biology
Online Access:	http://eprints.um.edu.my/32718/
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spelling	my.um.eprints.327182022-08-12T00:15:19Z http://eprints.um.edu.my/32718/ Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: A review Kanmalar, M. Abdul Sani, Siti Fairus Kamri, Nur Izzahtul Nabilla B. Mohd Said, Nur Akmarina Abd Jamil, Amirah Hajirah Kuppusamy, S. Mun, Kien Seong Bradley, D. A. QD Chemistry QH301 Biology Bladder cancer is the fourth most common malignancy in males. It can present across the whole continuum of severity, from mild through well-differentiated disease to extremely malignant tumours with poor survival rates. As with other vital organ malignancies, proper clinical management involves accurate diagnosis and staging. Chemotherapy consisting of a cisplatin-based regimen is the mainstay in the management of muscle-invasive bladder cancers. Control via cisplatin-based chemotherapy is threatened by the development of chemoresistance. Intracellular cholesterol biosynthesis in bladder cancer cells is considered a contributory factor in determining the chemotherapy response. Farnesyl-diphosphate farnesyltransferase 1 (FDFT1), one of the main regulatory components in cholesterol biosynthesis, may play a role in determining sensitivity towards chemotherapy compounds in bladder cancer. FDFT1-associated molecular identification might serve as an alternative or appendage strategy for early prediction of potentially chemoresistant muscle-invasive bladder cancer tissues. This can be accomplished using Raman spectroscopy. Developments in the instrumentation have led to it becoming one of the most convenient forms of analysis, and there is a highly realistic chance that it will become an effective tool in the pathology lab. Chemosensitive bladder cancer tissues tend to have a higher lipid content, more protein genes and more cholesterol metabolites. These are believed to be associated with resistance towards bladder cancer chemotherapy. Herein, Raman peak assignments have been tabulated as an aid to indicating metabolic changes in bladder cancer tissues that are potentially correlated with FDFT1 expression. BMC 2022-12 Article PeerReviewed Kanmalar, M. and Abdul Sani, Siti Fairus and Kamri, Nur Izzahtul Nabilla B. and Mohd Said, Nur Akmarina and Abd Jamil, Amirah Hajirah and Kuppusamy, S. and Mun, Kien Seong and Bradley, D. A. (2022) Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: A review. Cellular & Molecular Biology Letters, 27 (1). ISSN 1689-1392, DOI https://doi.org/10.1186/s11658-022-00307-x <https://doi.org/10.1186/s11658-022-00307-x>. 10.1186/s11658-022-00307-x
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	QD Chemistry QH301 Biology
spellingShingle	QD Chemistry QH301 Biology Kanmalar, M. Abdul Sani, Siti Fairus Kamri, Nur Izzahtul Nabilla B. Mohd Said, Nur Akmarina Abd Jamil, Amirah Hajirah Kuppusamy, S. Mun, Kien Seong Bradley, D. A. Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: A review
description	Bladder cancer is the fourth most common malignancy in males. It can present across the whole continuum of severity, from mild through well-differentiated disease to extremely malignant tumours with poor survival rates. As with other vital organ malignancies, proper clinical management involves accurate diagnosis and staging. Chemotherapy consisting of a cisplatin-based regimen is the mainstay in the management of muscle-invasive bladder cancers. Control via cisplatin-based chemotherapy is threatened by the development of chemoresistance. Intracellular cholesterol biosynthesis in bladder cancer cells is considered a contributory factor in determining the chemotherapy response. Farnesyl-diphosphate farnesyltransferase 1 (FDFT1), one of the main regulatory components in cholesterol biosynthesis, may play a role in determining sensitivity towards chemotherapy compounds in bladder cancer. FDFT1-associated molecular identification might serve as an alternative or appendage strategy for early prediction of potentially chemoresistant muscle-invasive bladder cancer tissues. This can be accomplished using Raman spectroscopy. Developments in the instrumentation have led to it becoming one of the most convenient forms of analysis, and there is a highly realistic chance that it will become an effective tool in the pathology lab. Chemosensitive bladder cancer tissues tend to have a higher lipid content, more protein genes and more cholesterol metabolites. These are believed to be associated with resistance towards bladder cancer chemotherapy. Herein, Raman peak assignments have been tabulated as an aid to indicating metabolic changes in bladder cancer tissues that are potentially correlated with FDFT1 expression.
format	Article
author	Kanmalar, M. Abdul Sani, Siti Fairus Kamri, Nur Izzahtul Nabilla B. Mohd Said, Nur Akmarina Abd Jamil, Amirah Hajirah Kuppusamy, S. Mun, Kien Seong Bradley, D. A.
author_facet	Kanmalar, M. Abdul Sani, Siti Fairus Kamri, Nur Izzahtul Nabilla B. Mohd Said, Nur Akmarina Abd Jamil, Amirah Hajirah Kuppusamy, S. Mun, Kien Seong Bradley, D. A.
author_sort	Kanmalar, M.
title	Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: A review
title_short	Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: A review
title_full	Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: A review
title_fullStr	Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: A review
title_full_unstemmed	Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: A review
title_sort	raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by fdft1: a review
publisher	BMC
publishDate	2022
url	http://eprints.um.edu.my/32718/
_version_	1744649145840304128
score	13.211869

Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: A review

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