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Comparative analysis of autologous chondrocyte implantation and other treatment modalities: a systematic review

Purpose The purpose of this systematic review was to analyze and determine the effectiveness of autologous chondrocyte implantation (ACI) when compared with other treatment modalities, which includes microfracture, mosaicplasty, abrasionplasty, bone marrow�derived mesenchymal stem cell (BMSC), and...

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Main Authors: Sangeetha, N., Noorzurani, R., Kamarul, Tunku
Format: Article
Language:English
Published: 2011
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/3200/1/comparative_analysis_of_autologous_chondrocyte_implanation_%28ACI%29_and_other_treatment_modalities.pdf
http://eprints.um.edu.my/3200/
http://www.springerlink.com/content/mt486t177211h111/abstract/
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spelling my.um.eprints.32002018-10-10T08:42:44Z http://eprints.um.edu.my/3200/ Comparative analysis of autologous chondrocyte implantation and other treatment modalities: a systematic review Sangeetha, N. Noorzurani, R. Kamarul, Tunku R Medicine Purpose The purpose of this systematic review was to analyze and determine the effectiveness of autologous chondrocyte implantation (ACI) when compared with other treatment modalities, which includes microfracture, mosaicplasty, abrasionplasty, bone marrow�derived mesenchymal stem cell (BMSC), and matrix-assisted autologous chondrocyte implantation (MACI). Methods Literature search using online databases PubMed, Scopus, National Institute for Clinical Excellence and Cochrane controlled trial register regarding all cell-based therapies and other interventions for chondral lesions was explored. Data on clinical outcome and repair quality were analyzed. Duplicates and irrelevant articles were omitted. Result Seventeen ( n = 17) studies were included in this review. Among the four trials on ACI versus mosaicplasty, two studies showed no differences in clinical scores, one suggested similar performance while the other suggested better results in tissue quality for ACI. A systematically performed assessment comparing ACI with microfracture shows better clinical outcomes and higher tissue quality after ACI. Studies comparing ACI with MACI or BMSC demonstrated similar results. Although many of these studies had substantial flaws, on the overall, the evidence comparing ACI with other treatment modalities shows better clinical outcomes and higher tissue quality. Conclusion Despite significant differences between the methodologies employed by different researchers, we can conclude that all except two studies demonstrated ACI being the better treatment for cartilage defects. However, final conclusions regarding long-term effects are still difficult, and therefore, future studies are needed to answer the long-term effects of ACI. 2011 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3200/1/comparative_analysis_of_autologous_chondrocyte_implanation_%28ACI%29_and_other_treatment_modalities.pdf Sangeetha, N. and Noorzurani, R. and Kamarul, Tunku (2011) Comparative analysis of autologous chondrocyte implantation and other treatment modalities: a systematic review. European Journal of Orthopaedic Surgery & Traumatology, 22 (2). pp. 89-96. ISSN 1633-8065 http://www.springerlink.com/content/mt486t177211h111/abstract/ 10.1007/s00590-011-0798-6
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine
spellingShingle R Medicine
Sangeetha, N.
Noorzurani, R.
Kamarul, Tunku
Comparative analysis of autologous chondrocyte implantation and other treatment modalities: a systematic review
description Purpose The purpose of this systematic review was to analyze and determine the effectiveness of autologous chondrocyte implantation (ACI) when compared with other treatment modalities, which includes microfracture, mosaicplasty, abrasionplasty, bone marrow�derived mesenchymal stem cell (BMSC), and matrix-assisted autologous chondrocyte implantation (MACI). Methods Literature search using online databases PubMed, Scopus, National Institute for Clinical Excellence and Cochrane controlled trial register regarding all cell-based therapies and other interventions for chondral lesions was explored. Data on clinical outcome and repair quality were analyzed. Duplicates and irrelevant articles were omitted. Result Seventeen ( n = 17) studies were included in this review. Among the four trials on ACI versus mosaicplasty, two studies showed no differences in clinical scores, one suggested similar performance while the other suggested better results in tissue quality for ACI. A systematically performed assessment comparing ACI with microfracture shows better clinical outcomes and higher tissue quality after ACI. Studies comparing ACI with MACI or BMSC demonstrated similar results. Although many of these studies had substantial flaws, on the overall, the evidence comparing ACI with other treatment modalities shows better clinical outcomes and higher tissue quality. Conclusion Despite significant differences between the methodologies employed by different researchers, we can conclude that all except two studies demonstrated ACI being the better treatment for cartilage defects. However, final conclusions regarding long-term effects are still difficult, and therefore, future studies are needed to answer the long-term effects of ACI.
format Article
author Sangeetha, N.
Noorzurani, R.
Kamarul, Tunku
author_facet Sangeetha, N.
Noorzurani, R.
Kamarul, Tunku
author_sort Sangeetha, N.
title Comparative analysis of autologous chondrocyte implantation and other treatment modalities: a systematic review
title_short Comparative analysis of autologous chondrocyte implantation and other treatment modalities: a systematic review
title_full Comparative analysis of autologous chondrocyte implantation and other treatment modalities: a systematic review
title_fullStr Comparative analysis of autologous chondrocyte implantation and other treatment modalities: a systematic review
title_full_unstemmed Comparative analysis of autologous chondrocyte implantation and other treatment modalities: a systematic review
title_sort comparative analysis of autologous chondrocyte implantation and other treatment modalities: a systematic review
publishDate 2011
url http://eprints.um.edu.my/3200/1/comparative_analysis_of_autologous_chondrocyte_implanation_%28ACI%29_and_other_treatment_modalities.pdf
http://eprints.um.edu.my/3200/
http://www.springerlink.com/content/mt486t177211h111/abstract/
_version_ 1643687065832914944
score 13.211869

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