Evidence of an interaction between nifedipine and nafcillin in humans
Aims: Nafcillin (Wyeth Laboratories, Philadelphia, PA, USA) has been reported to induce the metabolism of cyclosporin and warfarin, which are known substrates of cytochrome P‐450 (CYP). However, there has not been any report to date on its possible interaction with nifedipine, an index substrate of...
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2003
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my.um.eprints.30332021-12-30T08:33:48Z http://eprints.um.edu.my/3033/ Evidence of an interaction between nifedipine and nafcillin in humans Lang, C.C. Jamal, S.K. Mohamed, Z. Mustafa, Mohd Rais Mustafa, A.M. Lee, T.C. R Medicine Aims: Nafcillin (Wyeth Laboratories, Philadelphia, PA, USA) has been reported to induce the metabolism of cyclosporin and warfarin, which are known substrates of cytochrome P‐450 (CYP). However, there has not been any report to date on its possible interaction with nifedipine, an index substrate of the enzyme, CYP3A4. Methods: Nine healthy normotensive subjects participated in this randomized placebo‐controlled two‐way crossover study examining the effects of 5 days’ pretreatment of nafcillin 500 mg or placebo four times daily on the pharmacokinetics of an oral dose of nifedipine 10 mg. Plasma nifedipine concentrations were measured by gas chromatography–mass spectro. Results: The area under the plasma nifedipine concentration–time curve (AUC0–α) in nafcillin‐pretreated subjects (80.9 ± 32.9 µg l−1 h−1) was significantly decreased compared with subjects who received only nifedipine (216.4 ± 93.2 µg l−1 h−1) (P < 0.001). Total plasma clearance of nifedipine (CL/F) was significantly increased with nafcillin pretreatment (138.5 ± 42.0 l h−1vs 56.5 ± 32.0 l h−1) (P < 0.002). Conclusions: The results show that nafcillin pretreatment markedly increased the clearance of nifedipine and suggest that nafcillin is a potent inducer of CYP enzyme. Wiley 2003 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3033/1/Evidence_of_an_interaction_between_nifedipine_and_nafcillin_in_humans.pdf Lang, C.C. and Jamal, S.K. and Mohamed, Z. and Mustafa, Mohd Rais and Mustafa, A.M. and Lee, T.C. (2003) Evidence of an interaction between nifedipine and nafcillin in humans. British Journal of Clinical Pharmacology, 55 (6). pp. 588-590. ISSN 0306-5251 https://doi.org/10.1046/j.1365-2125.2003.01789.x doi:10.1046/j.1365-2125.2003.01789.x |
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R Medicine Lang, C.C. Jamal, S.K. Mohamed, Z. Mustafa, Mohd Rais Mustafa, A.M. Lee, T.C. Evidence of an interaction between nifedipine and nafcillin in humans |
| description |
Aims: Nafcillin (Wyeth Laboratories, Philadelphia, PA, USA) has been reported to induce the metabolism of cyclosporin and warfarin, which are known substrates of cytochrome P‐450 (CYP). However, there has not been any report to date on its possible interaction with nifedipine, an index substrate of the enzyme, CYP3A4.
Methods: Nine healthy normotensive subjects participated in this randomized placebo‐controlled two‐way crossover study examining the effects of 5 days’ pretreatment of nafcillin 500 mg or placebo four times daily on the pharmacokinetics of an oral dose of nifedipine 10 mg. Plasma nifedipine concentrations were measured by gas chromatography–mass spectro.
Results: The area under the plasma nifedipine concentration–time curve (AUC0–α) in nafcillin‐pretreated subjects (80.9 ± 32.9 µg l−1 h−1) was significantly decreased compared with subjects who received only nifedipine (216.4 ± 93.2 µg l−1 h−1) (P < 0.001). Total plasma clearance of nifedipine (CL/F) was significantly increased with nafcillin pretreatment (138.5 ± 42.0 l h−1vs 56.5 ± 32.0 l h−1) (P < 0.002).
Conclusions: The results show that nafcillin pretreatment markedly increased the clearance of nifedipine and suggest that nafcillin is a potent inducer of CYP enzyme. |
| format |
Article |
| author |
Lang, C.C. Jamal, S.K. Mohamed, Z. Mustafa, Mohd Rais Mustafa, A.M. Lee, T.C. |
| author_facet |
Lang, C.C. Jamal, S.K. Mohamed, Z. Mustafa, Mohd Rais Mustafa, A.M. Lee, T.C. |
| author_sort |
Lang, C.C. |
| title |
Evidence of an interaction between nifedipine and nafcillin in humans |
| title_short |
Evidence of an interaction between nifedipine and nafcillin in humans |
| title_full |
Evidence of an interaction between nifedipine and nafcillin in humans |
| title_fullStr |
Evidence of an interaction between nifedipine and nafcillin in humans |
| title_full_unstemmed |
Evidence of an interaction between nifedipine and nafcillin in humans |
| title_sort |
evidence of an interaction between nifedipine and nafcillin in humans |
| publisher |
Wiley |
| publishDate |
2003 |
| url |
http://eprints.um.edu.my/3033/1/Evidence_of_an_interaction_between_nifedipine_and_nafcillin_in_humans.pdf http://eprints.um.edu.my/3033/ https://doi.org/10.1046/j.1365-2125.2003.01789.x |
| _version_ |
1720980442573701120 |
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13.211869 |