Staff View: Lack of association between Gly82Ser, 1704G/T and 2184A/G of RAGE gene polymorphisms and retinopathy susceptibility in Malaysian diabetic patients.

Lack of association between Gly82Ser, 1704G/T and 2184A/G of RAGE gene polymorphisms and retinopathy susceptibility in Malaysian diabetic patients.

Diabetic retinopathy is the most common diabetic eye disease, occurring in about 60% of type 2 diabetic patients. Other than known clinical risk factors, the influence of genes has been suggested as part of the development of diabetic retinopathy. We investigated the association of Gly82Ser, 1704G/T...

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Main Authors:	Ng, Z.X., Kuppusamy, U.R., Poh, R., Tajunisah, I., Koay, A.C., Fong, K.C., Chua, K.H.
Format:	Article
Published:	2012
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/2944/ http://www.ncbi.nlm.nih.gov/pubmed/22427038
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id	my.um.eprints.2944
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spelling	my.um.eprints.29442014-12-21T09:40:38Z http://eprints.um.edu.my/2944/ Lack of association between Gly82Ser, 1704G/T and 2184A/G of RAGE gene polymorphisms and retinopathy susceptibility in Malaysian diabetic patients. Ng, Z.X. Kuppusamy, U.R. Poh, R. Tajunisah, I. Koay, A.C. Fong, K.C. Chua, K.H. R Medicine Diabetic retinopathy is the most common diabetic eye disease, occurring in about 60% of type 2 diabetic patients. Other than known clinical risk factors, the influence of genes has been suggested as part of the development of diabetic retinopathy. We investigated the association of Gly82Ser, 1704G/T and 2184A/G polymorphisms in the RAGE gene with retinopathy in type 2 diabetic patients in Malaysia. Ninety-eight unrelated retinopathy patients and 185 unrelated healthy controls from all over Malaysia were recruited in this study. The allele and genotype frequencies of the three gene polymorphisms were investigated using PCR-RFLP. The allele frequency of the three polymorphisms did not differ significantly between the control and the retinopathy group (P > 0.05). Analysis of the frequency of GA+AA, GT+TT and AG+GG in the retinopathy group did not reveal significant differences (P > 0.05) compared to the control group. We conclude that RAGE gene Gly82Ser, 1704G/T and 2184A/G polymorphisms are not associated with retinopathy development in the Malaysian population. 2012-03-10 Article PeerReviewed Ng, Z.X. and Kuppusamy, U.R. and Poh, R. and Tajunisah, I. and Koay, A.C. and Fong, K.C. and Chua, K.H. (2012) Lack of association between Gly82Ser, 1704G/T and 2184A/G of RAGE gene polymorphisms and retinopathy susceptibility in Malaysian diabetic patients. Genetics and Molecular Research, 11 (1). ISSN 1676-5680 http://www.ncbi.nlm.nih.gov/pubmed/22427038 PMID: 22427038
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine
spellingShingle	R Medicine Ng, Z.X. Kuppusamy, U.R. Poh, R. Tajunisah, I. Koay, A.C. Fong, K.C. Chua, K.H. Lack of association between Gly82Ser, 1704G/T and 2184A/G of RAGE gene polymorphisms and retinopathy susceptibility in Malaysian diabetic patients.
description	Diabetic retinopathy is the most common diabetic eye disease, occurring in about 60% of type 2 diabetic patients. Other than known clinical risk factors, the influence of genes has been suggested as part of the development of diabetic retinopathy. We investigated the association of Gly82Ser, 1704G/T and 2184A/G polymorphisms in the RAGE gene with retinopathy in type 2 diabetic patients in Malaysia. Ninety-eight unrelated retinopathy patients and 185 unrelated healthy controls from all over Malaysia were recruited in this study. The allele and genotype frequencies of the three gene polymorphisms were investigated using PCR-RFLP. The allele frequency of the three polymorphisms did not differ significantly between the control and the retinopathy group (P > 0.05). Analysis of the frequency of GA+AA, GT+TT and AG+GG in the retinopathy group did not reveal significant differences (P > 0.05) compared to the control group. We conclude that RAGE gene Gly82Ser, 1704G/T and 2184A/G polymorphisms are not associated with retinopathy development in the Malaysian population.
format	Article
author	Ng, Z.X. Kuppusamy, U.R. Poh, R. Tajunisah, I. Koay, A.C. Fong, K.C. Chua, K.H.
author_facet	Ng, Z.X. Kuppusamy, U.R. Poh, R. Tajunisah, I. Koay, A.C. Fong, K.C. Chua, K.H.
author_sort	Ng, Z.X.
title	Lack of association between Gly82Ser, 1704G/T and 2184A/G of RAGE gene polymorphisms and retinopathy susceptibility in Malaysian diabetic patients.
title_short	Lack of association between Gly82Ser, 1704G/T and 2184A/G of RAGE gene polymorphisms and retinopathy susceptibility in Malaysian diabetic patients.
title_full	Lack of association between Gly82Ser, 1704G/T and 2184A/G of RAGE gene polymorphisms and retinopathy susceptibility in Malaysian diabetic patients.
title_fullStr	Lack of association between Gly82Ser, 1704G/T and 2184A/G of RAGE gene polymorphisms and retinopathy susceptibility in Malaysian diabetic patients.
title_full_unstemmed	Lack of association between Gly82Ser, 1704G/T and 2184A/G of RAGE gene polymorphisms and retinopathy susceptibility in Malaysian diabetic patients.
title_sort	lack of association between gly82ser, 1704g/t and 2184a/g of rage gene polymorphisms and retinopathy susceptibility in malaysian diabetic patients.
publishDate	2012
url	http://eprints.um.edu.my/2944/ http://www.ncbi.nlm.nih.gov/pubmed/22427038
_version_	1643687012900798464
score	13.211869

Lack of association between Gly82Ser, 1704G/T and 2184A/G of RAGE gene polymorphisms and retinopathy susceptibility in Malaysian diabetic patients.

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