Staff View: Randomized controlled trial on the effect of partially hydrolyzed guar gum supplementation on diarrhea frequency and gut microbiome count among pelvic radiation patients

Randomized controlled trial on the effect of partially hydrolyzed guar gum supplementation on diarrhea frequency and gut microbiome count among pelvic radiation patients

Background Radiation therapy is the treatment of pelvic cancers, with diarrhea often being the most frequent acute side effect. This study aimed to determine the efficacy of partially hydrolyzed guar gum (PHGG) usage in reducing radiotherapy-induced diarrhea and improving bacterial count, nutrition...

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Main Authors:	Rosli, Dzairudzee, Shahar, Suzana, Manaf, Zahara Abdul, Lau, Hui Jin, Yusof, Nurul Yuziana Mohd, Haron, Mohd Roslan, Majid, Hazreen Abdul
Format:	Article
Published:	Wiley 2021
Subjects:	R Medicine Medical technology
Online Access:	http://eprints.um.edu.my/28867/
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spelling	my.um.eprints.288672022-04-21T07:55:29Z http://eprints.um.edu.my/28867/ Randomized controlled trial on the effect of partially hydrolyzed guar gum supplementation on diarrhea frequency and gut microbiome count among pelvic radiation patients Rosli, Dzairudzee Shahar, Suzana Manaf, Zahara Abdul Lau, Hui Jin Yusof, Nurul Yuziana Mohd Haron, Mohd Roslan Majid, Hazreen Abdul R Medicine Medical technology Background Radiation therapy is the treatment of pelvic cancers, with diarrhea often being the most frequent acute side effect. This study aimed to determine the efficacy of partially hydrolyzed guar gum (PHGG) usage in reducing radiotherapy-induced diarrhea and improving bacterial count, nutrition status, and quality of life (QoL) among cancer patients. Methods Adult patients undergoing pelvic radiation were recruited and randomly assigned to receive supplementation of either 10 g of PHGG or placebo (maltodextrin) twice daily, 14 days prior and 14 days during pelvic radiation. Diarrhea frequency, fecal samples, nutrition status, and QoL were assessed at baseline and days 14, 28 (2 weeks after pelvic radiation), and 45 (at the completion of pelvic radiation, 2 weeks' postsupplementation). Results A total of 30 patients (mean age 56.5 +/- 10.8 years, 75% malnourished) participated. The mean of diarrhea frequency in the intervention group (IG) was higher compared with the control group (CG) from days 14 and 28 but reduced at day 45. There was a significant intervention effect after controlling for confounders (ie, baseline diarrhea, age, nutrition status) (P< .05). Bifidobacterium count increased by double among the IG at 14 days of PHGG supplementation, whereas such trend was not observed in the CG. Conclusion Supplementation of PHGG potentially increased the bifidobacterial count and seemed to have post-supplementation effects by reducing the frequency of diarrhea upon the completion of pelvic radiation treatment. Wiley 2021-02 Article PeerReviewed Rosli, Dzairudzee and Shahar, Suzana and Manaf, Zahara Abdul and Lau, Hui Jin and Yusof, Nurul Yuziana Mohd and Haron, Mohd Roslan and Majid, Hazreen Abdul (2021) Randomized controlled trial on the effect of partially hydrolyzed guar gum supplementation on diarrhea frequency and gut microbiome count among pelvic radiation patients. Journal of Parenteral And Enteral Nutrition, 45 (2). pp. 277-286. ISSN 0148-6071, DOI https://doi.org/10.1002/jpen.1987 <https://doi.org/10.1002/jpen.1987>. 10.1002/jpen.1987
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine Medical technology
spellingShingle	R Medicine Medical technology Rosli, Dzairudzee Shahar, Suzana Manaf, Zahara Abdul Lau, Hui Jin Yusof, Nurul Yuziana Mohd Haron, Mohd Roslan Majid, Hazreen Abdul Randomized controlled trial on the effect of partially hydrolyzed guar gum supplementation on diarrhea frequency and gut microbiome count among pelvic radiation patients
description	Background Radiation therapy is the treatment of pelvic cancers, with diarrhea often being the most frequent acute side effect. This study aimed to determine the efficacy of partially hydrolyzed guar gum (PHGG) usage in reducing radiotherapy-induced diarrhea and improving bacterial count, nutrition status, and quality of life (QoL) among cancer patients. Methods Adult patients undergoing pelvic radiation were recruited and randomly assigned to receive supplementation of either 10 g of PHGG or placebo (maltodextrin) twice daily, 14 days prior and 14 days during pelvic radiation. Diarrhea frequency, fecal samples, nutrition status, and QoL were assessed at baseline and days 14, 28 (2 weeks after pelvic radiation), and 45 (at the completion of pelvic radiation, 2 weeks' postsupplementation). Results A total of 30 patients (mean age 56.5 +/- 10.8 years, 75% malnourished) participated. The mean of diarrhea frequency in the intervention group (IG) was higher compared with the control group (CG) from days 14 and 28 but reduced at day 45. There was a significant intervention effect after controlling for confounders (ie, baseline diarrhea, age, nutrition status) (P< .05). Bifidobacterium count increased by double among the IG at 14 days of PHGG supplementation, whereas such trend was not observed in the CG. Conclusion Supplementation of PHGG potentially increased the bifidobacterial count and seemed to have post-supplementation effects by reducing the frequency of diarrhea upon the completion of pelvic radiation treatment.
format	Article
author	Rosli, Dzairudzee Shahar, Suzana Manaf, Zahara Abdul Lau, Hui Jin Yusof, Nurul Yuziana Mohd Haron, Mohd Roslan Majid, Hazreen Abdul
author_facet	Rosli, Dzairudzee Shahar, Suzana Manaf, Zahara Abdul Lau, Hui Jin Yusof, Nurul Yuziana Mohd Haron, Mohd Roslan Majid, Hazreen Abdul
author_sort	Rosli, Dzairudzee
title	Randomized controlled trial on the effect of partially hydrolyzed guar gum supplementation on diarrhea frequency and gut microbiome count among pelvic radiation patients
title_short	Randomized controlled trial on the effect of partially hydrolyzed guar gum supplementation on diarrhea frequency and gut microbiome count among pelvic radiation patients
title_full	Randomized controlled trial on the effect of partially hydrolyzed guar gum supplementation on diarrhea frequency and gut microbiome count among pelvic radiation patients
title_fullStr	Randomized controlled trial on the effect of partially hydrolyzed guar gum supplementation on diarrhea frequency and gut microbiome count among pelvic radiation patients
title_full_unstemmed	Randomized controlled trial on the effect of partially hydrolyzed guar gum supplementation on diarrhea frequency and gut microbiome count among pelvic radiation patients
title_sort	randomized controlled trial on the effect of partially hydrolyzed guar gum supplementation on diarrhea frequency and gut microbiome count among pelvic radiation patients
publisher	Wiley
publishDate	2021
url	http://eprints.um.edu.my/28867/
_version_	1735409581758087168
score	13.211869

Randomized controlled trial on the effect of partially hydrolyzed guar gum supplementation on diarrhea frequency and gut microbiome count among pelvic radiation patients

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