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A rhodamine based chemosensor for solvent dependent chromogenic sensing of cobalt (II) and copper (II) ions with good selectivity and sensitivity: Synthesis, filter paper test strip, DFT calculations and cytotoxicity

A new chemosensor 1 was synthesized by reacting rhodamine B hydrazide and 2,3,4-trihydroxybenzaldehyde, which was then characterized by spectroscopic techniques and single crystal X-ray crystallography. Sensor 1 has the ability to sense Co2+/Cu2+ ions by ``naked-eye'' with an apparent colo...

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Main Authors: Chan, Wei Chuen, Saad, Hazwani Mat, Sim, Kae Shin, Lee, Vannajan Sanghiran, Ang, Chee Wei, Yeong, Keng Yoon, Tan, Kong Wai
Format: Article
Published: Elsevier 2021
Subjects:
Q Science (General)
QD Chemistry
Online Access:http://eprints.um.edu.my/28560/
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spelling my.um.eprints.285602022-08-16T10:34:11Z http://eprints.um.edu.my/28560/ A rhodamine based chemosensor for solvent dependent chromogenic sensing of cobalt (II) and copper (II) ions with good selectivity and sensitivity: Synthesis, filter paper test strip, DFT calculations and cytotoxicity Chan, Wei Chuen Saad, Hazwani Mat Sim, Kae Shin Lee, Vannajan Sanghiran Ang, Chee Wei Yeong, Keng Yoon Tan, Kong Wai Q Science (General) QD Chemistry A new chemosensor 1 was synthesized by reacting rhodamine B hydrazide and 2,3,4-trihydroxybenzaldehyde, which was then characterized by spectroscopic techniques and single crystal X-ray crystallography. Sensor 1 has the ability to sense Co2+/Cu2+ ions by ``naked-eye'' with an apparent colour change from colourless to pink in different solvent system, MeCN and DMF respectively. Furthermore, it can selectively detect Co2+/Cu2+ among wide range of different metal ions, and it exhibits low detection limit of 4.425 x 10(-8) M and 1.398 x 10(-7) M respectively. Binding mode of the two complexes were determined to be 1:1 stoichiometry for Co2+ complex and 1:2 stoichiometry for Cu2+ complex through Job's plot, IR spectroscopy, mass spectrometry and H-1 NMR spectroscopy. Moreover, reversibility of the sensor 1 as copper (II) ion detector was determined by using EDTA and the results showed that sensor 1 can be reused for at least 6 cycles. Other than that, a low cost chemosensor test strips were fabricated for the convenient ``naked-eye'' detection of Co2+ and Cu2+ in pure aqueous media. The MTT assay was conducted in order to determine the cytotoxicity of sensor 1 towards human cell lines. (C) 2021 Elsevier B.V. All rights reserved. Elsevier 2021-12-05 Article PeerReviewed Chan, Wei Chuen and Saad, Hazwani Mat and Sim, Kae Shin and Lee, Vannajan Sanghiran and Ang, Chee Wei and Yeong, Keng Yoon and Tan, Kong Wai (2021) A rhodamine based chemosensor for solvent dependent chromogenic sensing of cobalt (II) and copper (II) ions with good selectivity and sensitivity: Synthesis, filter paper test strip, DFT calculations and cytotoxicity. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 262. ISSN 1386-1425, DOI https://doi.org/10.1016/j.saa.2021.120099 <https://doi.org/10.1016/j.saa.2021.120099>. 10.1016/j.saa.2021.120099
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
QD Chemistry
spellingShingle Q Science (General)
QD Chemistry
Chan, Wei Chuen
Saad, Hazwani Mat
Sim, Kae Shin
Lee, Vannajan Sanghiran
Ang, Chee Wei
Yeong, Keng Yoon
Tan, Kong Wai
A rhodamine based chemosensor for solvent dependent chromogenic sensing of cobalt (II) and copper (II) ions with good selectivity and sensitivity: Synthesis, filter paper test strip, DFT calculations and cytotoxicity
description A new chemosensor 1 was synthesized by reacting rhodamine B hydrazide and 2,3,4-trihydroxybenzaldehyde, which was then characterized by spectroscopic techniques and single crystal X-ray crystallography. Sensor 1 has the ability to sense Co2+/Cu2+ ions by ``naked-eye'' with an apparent colour change from colourless to pink in different solvent system, MeCN and DMF respectively. Furthermore, it can selectively detect Co2+/Cu2+ among wide range of different metal ions, and it exhibits low detection limit of 4.425 x 10(-8) M and 1.398 x 10(-7) M respectively. Binding mode of the two complexes were determined to be 1:1 stoichiometry for Co2+ complex and 1:2 stoichiometry for Cu2+ complex through Job's plot, IR spectroscopy, mass spectrometry and H-1 NMR spectroscopy. Moreover, reversibility of the sensor 1 as copper (II) ion detector was determined by using EDTA and the results showed that sensor 1 can be reused for at least 6 cycles. Other than that, a low cost chemosensor test strips were fabricated for the convenient ``naked-eye'' detection of Co2+ and Cu2+ in pure aqueous media. The MTT assay was conducted in order to determine the cytotoxicity of sensor 1 towards human cell lines. (C) 2021 Elsevier B.V. All rights reserved.
format Article
author Chan, Wei Chuen
Saad, Hazwani Mat
Sim, Kae Shin
Lee, Vannajan Sanghiran
Ang, Chee Wei
Yeong, Keng Yoon
Tan, Kong Wai
author_facet Chan, Wei Chuen
Saad, Hazwani Mat
Sim, Kae Shin
Lee, Vannajan Sanghiran
Ang, Chee Wei
Yeong, Keng Yoon
Tan, Kong Wai
author_sort Chan, Wei Chuen
title A rhodamine based chemosensor for solvent dependent chromogenic sensing of cobalt (II) and copper (II) ions with good selectivity and sensitivity: Synthesis, filter paper test strip, DFT calculations and cytotoxicity
title_short A rhodamine based chemosensor for solvent dependent chromogenic sensing of cobalt (II) and copper (II) ions with good selectivity and sensitivity: Synthesis, filter paper test strip, DFT calculations and cytotoxicity
title_full A rhodamine based chemosensor for solvent dependent chromogenic sensing of cobalt (II) and copper (II) ions with good selectivity and sensitivity: Synthesis, filter paper test strip, DFT calculations and cytotoxicity
title_fullStr A rhodamine based chemosensor for solvent dependent chromogenic sensing of cobalt (II) and copper (II) ions with good selectivity and sensitivity: Synthesis, filter paper test strip, DFT calculations and cytotoxicity
title_full_unstemmed A rhodamine based chemosensor for solvent dependent chromogenic sensing of cobalt (II) and copper (II) ions with good selectivity and sensitivity: Synthesis, filter paper test strip, DFT calculations and cytotoxicity
title_sort rhodamine based chemosensor for solvent dependent chromogenic sensing of cobalt (ii) and copper (ii) ions with good selectivity and sensitivity: synthesis, filter paper test strip, dft calculations and cytotoxicity
publisher Elsevier
publishDate 2021
url http://eprints.um.edu.my/28560/
_version_ 1744649126877855744
score 13.211869

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