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Synthesis, characterization and in vitro analysis of superparamagnetic iron oxide nanoparticles for targeted hyperthermia therapy

Superparamagnetic iron oxide nanoparticles (SPIONs) are considered as promising magnetic nanoheating agents for diagnostic as well as therapeutic applications due to their biocompatibility and tunability of magnetic properties. These nanoheating agents are commonly synthesized by coprecipitation of...

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Main Authors: Hedayatnasab, Ziba, Dabbagh, Ali, Abnisa, Faisal, Karimian, Hamed, Abu Kasim, Noor Hayaty, Daud, Wan Mohd Ashri Wan
Format: Article
Published: Springer International Publishing AG 2021
Subjects:
T Technology (General)
TP Chemical technology
Online Access:http://eprints.um.edu.my/28552/
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spelling my.um.eprints.285522022-08-16T04:30:16Z http://eprints.um.edu.my/28552/ Synthesis, characterization and in vitro analysis of superparamagnetic iron oxide nanoparticles for targeted hyperthermia therapy Hedayatnasab, Ziba Dabbagh, Ali Abnisa, Faisal Karimian, Hamed Abu Kasim, Noor Hayaty Daud, Wan Mohd Ashri Wan T Technology (General) TP Chemical technology Superparamagnetic iron oxide nanoparticles (SPIONs) are considered as promising magnetic nanoheating agents for diagnostic as well as therapeutic applications due to their biocompatibility and tunability of magnetic properties. These nanoheating agents are commonly synthesized by coprecipitation of two iron precursors, though applying less amount of these chemicals may minimize the toxicity risks for biomedical purposes. The aim of this study is to address this issue by considering the high oxidation vulnerability of ferrous ions to ferric ions to synthesize SPIONs via a single-iron precursor under four varied oxidative conditions. The obtained results implied that the properties of SPIONs can be modified by the variation in the oxidizing conditions. Thereby, the optimal sample was produced as the oxygen/nitrogen flow ratio adjusted to 50% in the synthesis environment. The induction heating efficiency of this optimal sample was investigated under the exposure of varied alternating magnetic field (AMF), which resulted in a remarkable specific absorption rate (SAR) of 168.96 W g(-1) while maintaining the temperature medium within the secure hyperthermia range. The cytotoxic effect of the optimal SPIONs sample against human liver carcinoma (HepG2) cells was determined using MTT assay, leading to a considerable decrement in the cell viability. The incorporation of SPIONs under the AMF exposure is, therefore, considered as an effectual mechanism to the tumor intervention. GRAPHICS] . Springer International Publishing AG 2021-02 Article PeerReviewed Hedayatnasab, Ziba and Dabbagh, Ali and Abnisa, Faisal and Karimian, Hamed and Abu Kasim, Noor Hayaty and Daud, Wan Mohd Ashri Wan (2021) Synthesis, characterization and in vitro analysis of superparamagnetic iron oxide nanoparticles for targeted hyperthermia therapy. Chemical Papers, 75 (2). pp. 669-679. ISSN 2585-7290, DOI https://doi.org/10.1007/s11696-020-01265-4 <https://doi.org/10.1007/s11696-020-01265-4>. 10.1007/s11696-020-01265-4
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic T Technology (General)
TP Chemical technology
spellingShingle T Technology (General)
TP Chemical technology
Hedayatnasab, Ziba
Dabbagh, Ali
Abnisa, Faisal
Karimian, Hamed
Abu Kasim, Noor Hayaty
Daud, Wan Mohd Ashri Wan
Synthesis, characterization and in vitro analysis of superparamagnetic iron oxide nanoparticles for targeted hyperthermia therapy
description Superparamagnetic iron oxide nanoparticles (SPIONs) are considered as promising magnetic nanoheating agents for diagnostic as well as therapeutic applications due to their biocompatibility and tunability of magnetic properties. These nanoheating agents are commonly synthesized by coprecipitation of two iron precursors, though applying less amount of these chemicals may minimize the toxicity risks for biomedical purposes. The aim of this study is to address this issue by considering the high oxidation vulnerability of ferrous ions to ferric ions to synthesize SPIONs via a single-iron precursor under four varied oxidative conditions. The obtained results implied that the properties of SPIONs can be modified by the variation in the oxidizing conditions. Thereby, the optimal sample was produced as the oxygen/nitrogen flow ratio adjusted to 50% in the synthesis environment. The induction heating efficiency of this optimal sample was investigated under the exposure of varied alternating magnetic field (AMF), which resulted in a remarkable specific absorption rate (SAR) of 168.96 W g(-1) while maintaining the temperature medium within the secure hyperthermia range. The cytotoxic effect of the optimal SPIONs sample against human liver carcinoma (HepG2) cells was determined using MTT assay, leading to a considerable decrement in the cell viability. The incorporation of SPIONs under the AMF exposure is, therefore, considered as an effectual mechanism to the tumor intervention. GRAPHICS] .
format Article
author Hedayatnasab, Ziba
Dabbagh, Ali
Abnisa, Faisal
Karimian, Hamed
Abu Kasim, Noor Hayaty
Daud, Wan Mohd Ashri Wan
author_facet Hedayatnasab, Ziba
Dabbagh, Ali
Abnisa, Faisal
Karimian, Hamed
Abu Kasim, Noor Hayaty
Daud, Wan Mohd Ashri Wan
author_sort Hedayatnasab, Ziba
title Synthesis, characterization and in vitro analysis of superparamagnetic iron oxide nanoparticles for targeted hyperthermia therapy
title_short Synthesis, characterization and in vitro analysis of superparamagnetic iron oxide nanoparticles for targeted hyperthermia therapy
title_full Synthesis, characterization and in vitro analysis of superparamagnetic iron oxide nanoparticles for targeted hyperthermia therapy
title_fullStr Synthesis, characterization and in vitro analysis of superparamagnetic iron oxide nanoparticles for targeted hyperthermia therapy
title_full_unstemmed Synthesis, characterization and in vitro analysis of superparamagnetic iron oxide nanoparticles for targeted hyperthermia therapy
title_sort synthesis, characterization and in vitro analysis of superparamagnetic iron oxide nanoparticles for targeted hyperthermia therapy
publisher Springer International Publishing AG
publishDate 2021
url http://eprints.um.edu.my/28552/
_version_ 1744649126202572800
score 13.211869

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