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Injection of botulinum toxin type A (BOTOX) into trigger zone of trigeminal neuralgia as a means to control pain

This article illustrates a case of persistent trigeminal neuralgia in a medically compromised 65-year-old female who did not respond to pharmacotherapy. She had undergone several peripheral neurectomies as well as a failed right posterior fossa exploration that resulted in a cerebrospinal fluid leak...

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Main Authors: Ngeow, Wei Cheong, Nair, R.
Format: Article
Language:English
Published: MOSBY-ELSEVIER, 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA 2010
Subjects:
R Medicine
RK Dentistry
Online Access:http://eprints.um.edu.my/2842/1/Injection_of_botulinum_toxin_type_A_%28BOTOX%29_into_trigger_zone_of_trigeminal_neuralgia_as_a_means_to_control_pain.pdf
http://eprints.um.edu.my/2842/
http://www.ncbi.nlm.nih.gov/pubmed/20219585
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spelling my.um.eprints.28422019-09-27T08:49:57Z http://eprints.um.edu.my/2842/ Injection of botulinum toxin type A (BOTOX) into trigger zone of trigeminal neuralgia as a means to control pain Ngeow, Wei Cheong Nair, R. R Medicine RK Dentistry This article illustrates a case of persistent trigeminal neuralgia in a medically compromised 65-year-old female who did not respond to pharmacotherapy. She had undergone several peripheral neurectomies as well as a failed right posterior fossa exploration that resulted in a cerebrospinal fluid leak. Persistent pain over the right external nasal area and right mental region was relieved for several hours after daily injections of bupivacaine. A trial of a single dose of 100 units of botulinum toxin type A (BOTOX) diluted in 2.5 mL saline was injected into the external nasal trigger zone (60 units) and to the mental nerve region (40 units). She achieved complete pain relief in the external nasal region for 5 months. Pain recurred and the site was again injected with 100 units of botulinum toxin type A (BOTOX). Pain relief at the mental region was partial. This was finally controlled with peripheral neurectomy. The patient was pain free with a maintenance dose of 200 mg carbamazepine daily for about 1 year, after which she elected to undergo stereotactic gamma knife radiosurgery when pain recurred at the external nasal region. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: e47-e50) MOSBY-ELSEVIER, 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA 2010-03 Article PeerReviewed application/pdf en http://eprints.um.edu.my/2842/1/Injection_of_botulinum_toxin_type_A_%28BOTOX%29_into_trigger_zone_of_trigeminal_neuralgia_as_a_means_to_control_pain.pdf Ngeow, Wei Cheong and Nair, R. (2010) Injection of botulinum toxin type A (BOTOX) into trigger zone of trigeminal neuralgia as a means to control pain. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 109 (3). E47-E50. ISSN 1079-2104 http://www.ncbi.nlm.nih.gov/pubmed/20219585 10.1016/j.tripleo.2009.03.021
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine
RK Dentistry
spellingShingle R Medicine
RK Dentistry
Ngeow, Wei Cheong
Nair, R.
Injection of botulinum toxin type A (BOTOX) into trigger zone of trigeminal neuralgia as a means to control pain
description This article illustrates a case of persistent trigeminal neuralgia in a medically compromised 65-year-old female who did not respond to pharmacotherapy. She had undergone several peripheral neurectomies as well as a failed right posterior fossa exploration that resulted in a cerebrospinal fluid leak. Persistent pain over the right external nasal area and right mental region was relieved for several hours after daily injections of bupivacaine. A trial of a single dose of 100 units of botulinum toxin type A (BOTOX) diluted in 2.5 mL saline was injected into the external nasal trigger zone (60 units) and to the mental nerve region (40 units). She achieved complete pain relief in the external nasal region for 5 months. Pain recurred and the site was again injected with 100 units of botulinum toxin type A (BOTOX). Pain relief at the mental region was partial. This was finally controlled with peripheral neurectomy. The patient was pain free with a maintenance dose of 200 mg carbamazepine daily for about 1 year, after which she elected to undergo stereotactic gamma knife radiosurgery when pain recurred at the external nasal region. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: e47-e50)
format Article
author Ngeow, Wei Cheong
Nair, R.
author_facet Ngeow, Wei Cheong
Nair, R.
author_sort Ngeow, Wei Cheong
title Injection of botulinum toxin type A (BOTOX) into trigger zone of trigeminal neuralgia as a means to control pain
title_short Injection of botulinum toxin type A (BOTOX) into trigger zone of trigeminal neuralgia as a means to control pain
title_full Injection of botulinum toxin type A (BOTOX) into trigger zone of trigeminal neuralgia as a means to control pain
title_fullStr Injection of botulinum toxin type A (BOTOX) into trigger zone of trigeminal neuralgia as a means to control pain
title_full_unstemmed Injection of botulinum toxin type A (BOTOX) into trigger zone of trigeminal neuralgia as a means to control pain
title_sort injection of botulinum toxin type a (botox) into trigger zone of trigeminal neuralgia as a means to control pain
publisher MOSBY-ELSEVIER, 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
publishDate 2010
url http://eprints.um.edu.my/2842/1/Injection_of_botulinum_toxin_type_A_%28BOTOX%29_into_trigger_zone_of_trigeminal_neuralgia_as_a_means_to_control_pain.pdf
http://eprints.um.edu.my/2842/
http://www.ncbi.nlm.nih.gov/pubmed/20219585
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score 13.211869

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