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Prostaglandin-endoperoxide synthase (PTGS2) and Defensin beta 1 (DEFB1) gene polymorphisms are not associated with periodontitis in Malays

Introduction: In line with the association of prostaglandin-endoperoxide synthase 2 (PTGS2) and defensin beta 1 (DEFB1) single nucleotide polymorphisms (SNPs) with periodontitis among the Chinese and European populations, the current study was aimed to assess the same association among the Malays in...

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Main Authors: Jagender Singh, Jasmin Kaur, Vaithilingam, Rathna Devi, Ng, Ching Ching, Baharuddin, Nor Adinar, Hasnur Safii, Syarida, Rahman, Mohammad Tariqur
Format: Article
Published: Malaysian Journal Pathology, Univ Malaysia 2021
Subjects:
R Medicine (General)
RK Dentistry
Online Access:http://eprints.um.edu.my/28366/
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spelling my.um.eprints.283662022-07-31T14:42:30Z http://eprints.um.edu.my/28366/ Prostaglandin-endoperoxide synthase (PTGS2) and Defensin beta 1 (DEFB1) gene polymorphisms are not associated with periodontitis in Malays Jagender Singh, Jasmin Kaur Vaithilingam, Rathna Devi Ng, Ching Ching Baharuddin, Nor Adinar Hasnur Safii, Syarida Rahman, Mohammad Tariqur R Medicine (General) RK Dentistry Introduction: In line with the association of prostaglandin-endoperoxide synthase 2 (PTGS2) and defensin beta 1 (DEFB1) single nucleotide polymorphisms (SNPs) with periodontitis among the Chinese and European populations, the current study was aimed to assess the same association among the Malays in Malaysia. Methods: Blood samples of individuals with periodontitis (PD) (n=72) and periodontally healthy (PH) (n=62) donors were obtained from Malaysian Periodontal Database and rs20417, rs689466,) and one DEFB1 SNP (rs1047031) using Taqman SNP genotyping assays. Notably, rs20417 and rs689466 were located in the promoter region while rs5275 and rs1047031 were located in the 3' untranslated region of the transcript. Association between the SNPs and PD were then analyzed using genotypic association analysis (additive, dominant and recessive models). Results: The allelic frequency for the rs689466-G was higher in PD group (35.2%) compared that in PH group (29.0%). However, the association of rs689466-G and other SNPs with PD was not statistically significant (at 95% CI). No associations were observed for genotypic associations between the PTGS2 and DEFB1 SNPs with PD susceptibility. Conclusions: PTGS2 (rs5275, rs20417, and rs689466) and DEFB1 (rs1047031) polymorphism was not associated with PD in Malays, unlike the Chinese, Taiwanese & European population. This suggests that other causal variants might be involved in the development and progression of PD among Malays. Malaysian Journal Pathology, Univ Malaysia 2021-12 Article PeerReviewed Jagender Singh, Jasmin Kaur and Vaithilingam, Rathna Devi and Ng, Ching Ching and Baharuddin, Nor Adinar and Hasnur Safii, Syarida and Rahman, Mohammad Tariqur (2021) Prostaglandin-endoperoxide synthase (PTGS2) and Defensin beta 1 (DEFB1) gene polymorphisms are not associated with periodontitis in Malays. Malaysian Journal of Pathology, 43 (3). pp. 425-434. ISSN 0126-8635,
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine (General)
RK Dentistry
spellingShingle R Medicine (General)
RK Dentistry
Jagender Singh, Jasmin Kaur
Vaithilingam, Rathna Devi
Ng, Ching Ching
Baharuddin, Nor Adinar
Hasnur Safii, Syarida
Rahman, Mohammad Tariqur
Prostaglandin-endoperoxide synthase (PTGS2) and Defensin beta 1 (DEFB1) gene polymorphisms are not associated with periodontitis in Malays
description Introduction: In line with the association of prostaglandin-endoperoxide synthase 2 (PTGS2) and defensin beta 1 (DEFB1) single nucleotide polymorphisms (SNPs) with periodontitis among the Chinese and European populations, the current study was aimed to assess the same association among the Malays in Malaysia. Methods: Blood samples of individuals with periodontitis (PD) (n=72) and periodontally healthy (PH) (n=62) donors were obtained from Malaysian Periodontal Database and rs20417, rs689466,) and one DEFB1 SNP (rs1047031) using Taqman SNP genotyping assays. Notably, rs20417 and rs689466 were located in the promoter region while rs5275 and rs1047031 were located in the 3' untranslated region of the transcript. Association between the SNPs and PD were then analyzed using genotypic association analysis (additive, dominant and recessive models). Results: The allelic frequency for the rs689466-G was higher in PD group (35.2%) compared that in PH group (29.0%). However, the association of rs689466-G and other SNPs with PD was not statistically significant (at 95% CI). No associations were observed for genotypic associations between the PTGS2 and DEFB1 SNPs with PD susceptibility. Conclusions: PTGS2 (rs5275, rs20417, and rs689466) and DEFB1 (rs1047031) polymorphism was not associated with PD in Malays, unlike the Chinese, Taiwanese & European population. This suggests that other causal variants might be involved in the development and progression of PD among Malays.
format Article
author Jagender Singh, Jasmin Kaur
Vaithilingam, Rathna Devi
Ng, Ching Ching
Baharuddin, Nor Adinar
Hasnur Safii, Syarida
Rahman, Mohammad Tariqur
author_facet Jagender Singh, Jasmin Kaur
Vaithilingam, Rathna Devi
Ng, Ching Ching
Baharuddin, Nor Adinar
Hasnur Safii, Syarida
Rahman, Mohammad Tariqur
author_sort Jagender Singh, Jasmin Kaur
title Prostaglandin-endoperoxide synthase (PTGS2) and Defensin beta 1 (DEFB1) gene polymorphisms are not associated with periodontitis in Malays
title_short Prostaglandin-endoperoxide synthase (PTGS2) and Defensin beta 1 (DEFB1) gene polymorphisms are not associated with periodontitis in Malays
title_full Prostaglandin-endoperoxide synthase (PTGS2) and Defensin beta 1 (DEFB1) gene polymorphisms are not associated with periodontitis in Malays
title_fullStr Prostaglandin-endoperoxide synthase (PTGS2) and Defensin beta 1 (DEFB1) gene polymorphisms are not associated with periodontitis in Malays
title_full_unstemmed Prostaglandin-endoperoxide synthase (PTGS2) and Defensin beta 1 (DEFB1) gene polymorphisms are not associated with periodontitis in Malays
title_sort prostaglandin-endoperoxide synthase (ptgs2) and defensin beta 1 (defb1) gene polymorphisms are not associated with periodontitis in malays
publisher Malaysian Journal Pathology, Univ Malaysia
publishDate 2021
url http://eprints.um.edu.my/28366/
_version_ 1740826005387345920
score 13.222552

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