Staff View: Emerging SARS-CoV-2 variants of concern (VOCs): An impending global crisis

Emerging SARS-CoV-2 variants of concern (VOCs): An impending global crisis

The worldwide battle against the SARS-CoV-2 virus rages on, with millions infected and many innocent lives lost. The causative organism, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a beta coronavirus that belongs to the Coronaviridae family. Many clinically significant variants...

Full description

Saved in:

Bibliographic Details
Main Authors:	Thye, Angel Yun-Kuan, Law, Jodi Woan-Fei, Pusparajah, Priyia, Letchumanan, Vengadesh, Chan, Kok-Gan, Lee, Learn-Han
Format:	Article
Published:	MDPI 2021
Subjects:	QD Chemistry QH301 Biology RM Therapeutics. Pharmacology RS Pharmacy and materia medica
Online Access:	http://eprints.um.edu.my/28282/
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my.um.eprints.28282
record_format	eprints
spelling	my.um.eprints.282822022-04-08T00:17:30Z http://eprints.um.edu.my/28282/ Emerging SARS-CoV-2 variants of concern (VOCs): An impending global crisis Thye, Angel Yun-Kuan Law, Jodi Woan-Fei Pusparajah, Priyia Letchumanan, Vengadesh Chan, Kok-Gan Lee, Learn-Han QD Chemistry QH301 Biology RM Therapeutics. Pharmacology RS Pharmacy and materia medica The worldwide battle against the SARS-CoV-2 virus rages on, with millions infected and many innocent lives lost. The causative organism, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a beta coronavirus that belongs to the Coronaviridae family. Many clinically significant variants have emerged, as the virus's genome is prone to various mutations, leading to antigenic drift and resulting in evasion of host immune recognition. The current variants of concern (VOCs) include B.1.1.7 (Alpha), B.1.351 (Beta), B.1.617/B.1.617.2 (Delta), and P.1 (Gamma). The emerging variants contain various important mutations on the spike protein, leading to deleterious consequences, such as immune invasion and vaccine escape. These adverse effects result in increased transmissibility, morbidity, and mortality and the evasion of detection by existing or currently available diagnostic tests, potentially delaying diagnosis and treatment. This review discusses the key mutations present in the VOC strains and provides insights into how these mutations allow for greater transmissibility and immune evasion than the progenitor strain. Continuous monitoring and surveillance of VOC strains play a vital role in preventing and controlling the virus's spread.</p> MDPI 2021-10 Article PeerReviewed Thye, Angel Yun-Kuan and Law, Jodi Woan-Fei and Pusparajah, Priyia and Letchumanan, Vengadesh and Chan, Kok-Gan and Lee, Learn-Han (2021) Emerging SARS-CoV-2 variants of concern (VOCs): An impending global crisis. Biomedicines, 9 (10). ISSN 2227-9059, DOI https://doi.org/10.3390/biomedicines9101303 <https://doi.org/10.3390/biomedicines9101303>. 10.3390/biomedicines9101303
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	QD Chemistry QH301 Biology RM Therapeutics. Pharmacology RS Pharmacy and materia medica
spellingShingle	QD Chemistry QH301 Biology RM Therapeutics. Pharmacology RS Pharmacy and materia medica Thye, Angel Yun-Kuan Law, Jodi Woan-Fei Pusparajah, Priyia Letchumanan, Vengadesh Chan, Kok-Gan Lee, Learn-Han Emerging SARS-CoV-2 variants of concern (VOCs): An impending global crisis
description	The worldwide battle against the SARS-CoV-2 virus rages on, with millions infected and many innocent lives lost. The causative organism, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a beta coronavirus that belongs to the Coronaviridae family. Many clinically significant variants have emerged, as the virus's genome is prone to various mutations, leading to antigenic drift and resulting in evasion of host immune recognition. The current variants of concern (VOCs) include B.1.1.7 (Alpha), B.1.351 (Beta), B.1.617/B.1.617.2 (Delta), and P.1 (Gamma). The emerging variants contain various important mutations on the spike protein, leading to deleterious consequences, such as immune invasion and vaccine escape. These adverse effects result in increased transmissibility, morbidity, and mortality and the evasion of detection by existing or currently available diagnostic tests, potentially delaying diagnosis and treatment. This review discusses the key mutations present in the VOC strains and provides insights into how these mutations allow for greater transmissibility and immune evasion than the progenitor strain. Continuous monitoring and surveillance of VOC strains play a vital role in preventing and controlling the virus's spread.</p>
format	Article
author	Thye, Angel Yun-Kuan Law, Jodi Woan-Fei Pusparajah, Priyia Letchumanan, Vengadesh Chan, Kok-Gan Lee, Learn-Han
author_facet	Thye, Angel Yun-Kuan Law, Jodi Woan-Fei Pusparajah, Priyia Letchumanan, Vengadesh Chan, Kok-Gan Lee, Learn-Han
author_sort	Thye, Angel Yun-Kuan
title	Emerging SARS-CoV-2 variants of concern (VOCs): An impending global crisis
title_short	Emerging SARS-CoV-2 variants of concern (VOCs): An impending global crisis
title_full	Emerging SARS-CoV-2 variants of concern (VOCs): An impending global crisis
title_fullStr	Emerging SARS-CoV-2 variants of concern (VOCs): An impending global crisis
title_full_unstemmed	Emerging SARS-CoV-2 variants of concern (VOCs): An impending global crisis
title_sort	emerging sars-cov-2 variants of concern (vocs): an impending global crisis
publisher	MDPI
publishDate	2021
url	http://eprints.um.edu.my/28282/
_version_	1735409550664663040
score	13.211869

Emerging SARS-CoV-2 variants of concern (VOCs): An impending global crisis

Similar Items