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Attenuation parameter and liver stiffness measurement using FibroTouch vs Fibroscan in patients with chronic liver disease

Background & aim We studied FibroTouch (FT) and Fibroscan (FS) examination results and their repeatability when performed by healthcare personnel of different background. Methods FT and FS examinations were performed on patients with chronic liver disease by two operators, a doctor and a nurse,...

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Main Authors: Ng, Ying Zhuang, Lai, Lee Lee, Wong, Sui Weng, Mohamad, Siti Yatimah, Chuah, Kee Huat, Chan, Wah Kheong
Format: Article
Published: Public Library of Science 2021
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R Medicine
Online Access:http://eprints.um.edu.my/28217/
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spelling my.um.eprints.282172022-03-05T05:00:51Z http://eprints.um.edu.my/28217/ Attenuation parameter and liver stiffness measurement using FibroTouch vs Fibroscan in patients with chronic liver disease Ng, Ying Zhuang Lai, Lee Lee Wong, Sui Weng Mohamad, Siti Yatimah Chuah, Kee Huat Chan, Wah Kheong R Medicine Background & aim We studied FibroTouch (FT) and Fibroscan (FS) examination results and their repeatability when performed by healthcare personnel of different background. Methods FT and FS examinations were performed on patients with chronic liver disease by two operators, a doctor and a nurse, twice on each patient, at two different time points, independent of each other. Results The data for 163 patients with 1304 examinations was analyzed. There was strong correlation between FT and FS for attenuation parameter (Spearman's rho 0.76, p<0.001) and liver stiffness measurement (LSM) (Spearman's rho 0.70, p<0.001). However, FT produced higher value at lower attenuation parameter and LSM, and lower value at higher attenuation parameter and LSM. There was substantial agreement when using 15kPa LSM cut-off, but only moderate agreement when using 10kPa and 20kPa LSM cut-offs and 248dB/m, 268dB/m and 280dB/m attenuation parameter cut-offs. The IQR for attenuation parameter and IQR/median for LSM were significantly lower for FT compared with FS (4dB/m vs 27dB/m, p<0.001, and 10 vs 12, p<0.001, respectively). The intra- and inter-observer reliability of attenuation parameter and LSM using FT and FS were good to excellent with intraclass correlation coefficients 0.89-0.99. FT had shorter examination time (33s vs 47s, p<0.001) and less invalid measurements (0 vs 2, p<0.001). Conclusion Measurements obtained with FT and FS strongly correlated, but significant differences in their absolute values, consistency, examination time and number of invalid measurements were observed. Either device can be used by healthcare personnel of different backgrounds when sufficiently trained. Public Library of Science 2021-05-03 Article PeerReviewed Ng, Ying Zhuang and Lai, Lee Lee and Wong, Sui Weng and Mohamad, Siti Yatimah and Chuah, Kee Huat and Chan, Wah Kheong (2021) Attenuation parameter and liver stiffness measurement using FibroTouch vs Fibroscan in patients with chronic liver disease. PLoS ONE, 16 (5). ISSN 1932-6203, DOI https://doi.org/10.1371/journal.pone.0250300 <https://doi.org/10.1371/journal.pone.0250300>. 10.1371/journal.pone.0250300
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Ng, Ying Zhuang
Lai, Lee Lee
Wong, Sui Weng
Mohamad, Siti Yatimah
Chuah, Kee Huat
Chan, Wah Kheong
Attenuation parameter and liver stiffness measurement using FibroTouch vs Fibroscan in patients with chronic liver disease
description Background & aim We studied FibroTouch (FT) and Fibroscan (FS) examination results and their repeatability when performed by healthcare personnel of different background. Methods FT and FS examinations were performed on patients with chronic liver disease by two operators, a doctor and a nurse, twice on each patient, at two different time points, independent of each other. Results The data for 163 patients with 1304 examinations was analyzed. There was strong correlation between FT and FS for attenuation parameter (Spearman's rho 0.76, p<0.001) and liver stiffness measurement (LSM) (Spearman's rho 0.70, p<0.001). However, FT produced higher value at lower attenuation parameter and LSM, and lower value at higher attenuation parameter and LSM. There was substantial agreement when using 15kPa LSM cut-off, but only moderate agreement when using 10kPa and 20kPa LSM cut-offs and 248dB/m, 268dB/m and 280dB/m attenuation parameter cut-offs. The IQR for attenuation parameter and IQR/median for LSM were significantly lower for FT compared with FS (4dB/m vs 27dB/m, p<0.001, and 10 vs 12, p<0.001, respectively). The intra- and inter-observer reliability of attenuation parameter and LSM using FT and FS were good to excellent with intraclass correlation coefficients 0.89-0.99. FT had shorter examination time (33s vs 47s, p<0.001) and less invalid measurements (0 vs 2, p<0.001). Conclusion Measurements obtained with FT and FS strongly correlated, but significant differences in their absolute values, consistency, examination time and number of invalid measurements were observed. Either device can be used by healthcare personnel of different backgrounds when sufficiently trained.
format Article
author Ng, Ying Zhuang
Lai, Lee Lee
Wong, Sui Weng
Mohamad, Siti Yatimah
Chuah, Kee Huat
Chan, Wah Kheong
author_facet Ng, Ying Zhuang
Lai, Lee Lee
Wong, Sui Weng
Mohamad, Siti Yatimah
Chuah, Kee Huat
Chan, Wah Kheong
author_sort Ng, Ying Zhuang
title Attenuation parameter and liver stiffness measurement using FibroTouch vs Fibroscan in patients with chronic liver disease
title_short Attenuation parameter and liver stiffness measurement using FibroTouch vs Fibroscan in patients with chronic liver disease
title_full Attenuation parameter and liver stiffness measurement using FibroTouch vs Fibroscan in patients with chronic liver disease
title_fullStr Attenuation parameter and liver stiffness measurement using FibroTouch vs Fibroscan in patients with chronic liver disease
title_full_unstemmed Attenuation parameter and liver stiffness measurement using FibroTouch vs Fibroscan in patients with chronic liver disease
title_sort attenuation parameter and liver stiffness measurement using fibrotouch vs fibroscan in patients with chronic liver disease
publisher Public Library of Science
publishDate 2021
url http://eprints.um.edu.my/28217/
_version_ 1735409544509521920
score 13.211869

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