The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes.
1. Zidovudine (3'-azido-3'-deoxythymidine; AZT) is the drug of proven efficacy available for the treatment of patients with AIDS or ARC. It is eliminated mainly by hepatic glucuronidation. Therefore, interference with this metabolic pathway may lead to enhancement of AZT effect or to incre...
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| Main Authors: | , , |
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| Format: | Article |
| Published: |
Blackwell Publishing
1991
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/282/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1368487/?tool=pubmed |
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