Role of surface-exposed charged basic amino acids (Lys, Arg) and guanidination in insulin on the interaction and stability of insulin-insulin receptor complex
Naturally occurring proteins are emerging as novel therapeutics in the protein-based biopharmaceutical industry for the treatment of diabetes and obesity. However, proteins are not suitable for oral delivery due to short halflife, reduced physical and chemical stability and low permeability across t...
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| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
Elsevier Sci Ltd
2021
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/28083/ |
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