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Exploring the role and potential of probiotics in the field of mental health: Major depressive disorder

The field of probiotic has been exponentially expanding over the recent decades with a more therapeutic-centered research. Probiotics mediated microbiota modulation within the microbiota-gut-brain axis (MGBA) have been proven to be beneficial in various health domains through pre-clinical and clinic...

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Main Authors: Johnson, Dinyadarshini, Thurairajasingam, Sivakumar, Letchumanan, Vengadesh, Chan, Kok-Gan, Lee, Learn-Han
Format: Article
Published: 2021
Subjects:
RA0421 Public health. Hygiene. Preventive Medicine
RM Therapeutics. Pharmacology
Online Access:http://eprints.um.edu.my/27934/
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spelling my.um.eprints.279342022-04-13T00:39:12Z http://eprints.um.edu.my/27934/ Exploring the role and potential of probiotics in the field of mental health: Major depressive disorder Johnson, Dinyadarshini Thurairajasingam, Sivakumar Letchumanan, Vengadesh Chan, Kok-Gan Lee, Learn-Han RA0421 Public health. Hygiene. Preventive Medicine RM Therapeutics. Pharmacology The field of probiotic has been exponentially expanding over the recent decades with a more therapeutic-centered research. Probiotics mediated microbiota modulation within the microbiota-gut-brain axis (MGBA) have been proven to be beneficial in various health domains through pre-clinical and clinical studies. In the context of mental health, although probiotic research is still in its infancy stage, the promising role and potential of probiotics in various mental disorders demonstrated via in-vivo and in-vitro studies have laid a strong foundation for translating preclinical models to humans. The exploration of the therapeutic role and potential of probiotics in major depressive disorder (MDD) is an extremely noteworthy field of research. The possible etio-pathological mechanisms of depression involving inflammation, neurotransmitters, the hypothalamic-pituitary-adrenal (HPA) axis and epigenetic mechanisms potentially benefit from probiotic intervention. Probiotics, both as an adjunct to antidepressants or a stand-alone intervention, have a beneficial role and potential in mitigating anti-depressive effects, and confers some advantages compared to conventional treatments of depression using anti-depressants. 2021-05 Article PeerReviewed Johnson, Dinyadarshini and Thurairajasingam, Sivakumar and Letchumanan, Vengadesh and Chan, Kok-Gan and Lee, Learn-Han (2021) Exploring the role and potential of probiotics in the field of mental health: Major depressive disorder. Nutrients, 13 (5). ISSN 2072-6643, DOI https://doi.org/10.3390/nu13051728 <https://doi.org/10.3390/nu13051728>. 10.3390/nu13051728
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic RA0421 Public health. Hygiene. Preventive Medicine
RM Therapeutics. Pharmacology
spellingShingle RA0421 Public health. Hygiene. Preventive Medicine
RM Therapeutics. Pharmacology
Johnson, Dinyadarshini
Thurairajasingam, Sivakumar
Letchumanan, Vengadesh
Chan, Kok-Gan
Lee, Learn-Han
Exploring the role and potential of probiotics in the field of mental health: Major depressive disorder
description The field of probiotic has been exponentially expanding over the recent decades with a more therapeutic-centered research. Probiotics mediated microbiota modulation within the microbiota-gut-brain axis (MGBA) have been proven to be beneficial in various health domains through pre-clinical and clinical studies. In the context of mental health, although probiotic research is still in its infancy stage, the promising role and potential of probiotics in various mental disorders demonstrated via in-vivo and in-vitro studies have laid a strong foundation for translating preclinical models to humans. The exploration of the therapeutic role and potential of probiotics in major depressive disorder (MDD) is an extremely noteworthy field of research. The possible etio-pathological mechanisms of depression involving inflammation, neurotransmitters, the hypothalamic-pituitary-adrenal (HPA) axis and epigenetic mechanisms potentially benefit from probiotic intervention. Probiotics, both as an adjunct to antidepressants or a stand-alone intervention, have a beneficial role and potential in mitigating anti-depressive effects, and confers some advantages compared to conventional treatments of depression using anti-depressants.
format Article
author Johnson, Dinyadarshini
Thurairajasingam, Sivakumar
Letchumanan, Vengadesh
Chan, Kok-Gan
Lee, Learn-Han
author_facet Johnson, Dinyadarshini
Thurairajasingam, Sivakumar
Letchumanan, Vengadesh
Chan, Kok-Gan
Lee, Learn-Han
author_sort Johnson, Dinyadarshini
title Exploring the role and potential of probiotics in the field of mental health: Major depressive disorder
title_short Exploring the role and potential of probiotics in the field of mental health: Major depressive disorder
title_full Exploring the role and potential of probiotics in the field of mental health: Major depressive disorder
title_fullStr Exploring the role and potential of probiotics in the field of mental health: Major depressive disorder
title_full_unstemmed Exploring the role and potential of probiotics in the field of mental health: Major depressive disorder
title_sort exploring the role and potential of probiotics in the field of mental health: major depressive disorder
publishDate 2021
url http://eprints.um.edu.my/27934/
_version_ 1735409539862233088
score 13.211869

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