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Immunomodulation and regenerative capacity of MSCs for long-COVID

The rapid mutation of the SARS-CoV-2 virus is now a major concern with no effective drugs and treatments. The severity of the disease is linked to the induction of a cytokine storm that promotes extensive inflammation in the lung, leading to many acute lung injuries, pulmonary edema, and eventually...

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Main Authors:	Loke, Xin Ya, Imran, Siti A. M., Tye, Gee Jun, Wan Kamarul Zaman, Wan Safwani, Nordin, Fazlina
Format:	Article
Published:	MDPI 2021
Subjects:	R Medicine (General) TA Engineering (General). Civil engineering (General)
Online Access:	http://eprints.um.edu.my/27916/
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spelling	my.um.eprints.279162022-06-14T03:09:12Z http://eprints.um.edu.my/27916/ Immunomodulation and regenerative capacity of MSCs for long-COVID Loke, Xin Ya Imran, Siti A. M. Tye, Gee Jun Wan Kamarul Zaman, Wan Safwani Nordin, Fazlina R Medicine (General) TA Engineering (General). Civil engineering (General) The rapid mutation of the SARS-CoV-2 virus is now a major concern with no effective drugs and treatments. The severity of the disease is linked to the induction of a cytokine storm that promotes extensive inflammation in the lung, leading to many acute lung injuries, pulmonary edema, and eventually death. Mesenchymal stem cells (MSCs) might prove to be a treatment option as they have immunomodulation and regenerative properties. Clinical trials utilizing MSCs in treating acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) have provided a basis in treating post-COVID-19 patients. In this review, we discussed the effects of MSCs as an immunomodulator to reduce the severity and death in patients with COVID-19, including the usage of MSCs as an alternative regenerative therapy in post-COVID-19 patients. This review also includes the current clinical trials in utilizing MSCs and their potential future utilization for long-COVID treatments. MDPI 2021-11 Article PeerReviewed Loke, Xin Ya and Imran, Siti A. M. and Tye, Gee Jun and Wan Kamarul Zaman, Wan Safwani and Nordin, Fazlina (2021) Immunomodulation and regenerative capacity of MSCs for long-COVID. International Journal of Molecular Sciences, 22 (22). ISSN 1422-0067, DOI https://doi.org/10.3390/ijms222212421 <https://doi.org/10.3390/ijms222212421>. 10.3390/ijms222212421
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine (General) TA Engineering (General). Civil engineering (General)
spellingShingle	R Medicine (General) TA Engineering (General). Civil engineering (General) Loke, Xin Ya Imran, Siti A. M. Tye, Gee Jun Wan Kamarul Zaman, Wan Safwani Nordin, Fazlina Immunomodulation and regenerative capacity of MSCs for long-COVID
description	The rapid mutation of the SARS-CoV-2 virus is now a major concern with no effective drugs and treatments. The severity of the disease is linked to the induction of a cytokine storm that promotes extensive inflammation in the lung, leading to many acute lung injuries, pulmonary edema, and eventually death. Mesenchymal stem cells (MSCs) might prove to be a treatment option as they have immunomodulation and regenerative properties. Clinical trials utilizing MSCs in treating acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) have provided a basis in treating post-COVID-19 patients. In this review, we discussed the effects of MSCs as an immunomodulator to reduce the severity and death in patients with COVID-19, including the usage of MSCs as an alternative regenerative therapy in post-COVID-19 patients. This review also includes the current clinical trials in utilizing MSCs and their potential future utilization for long-COVID treatments.
format	Article
author	Loke, Xin Ya Imran, Siti A. M. Tye, Gee Jun Wan Kamarul Zaman, Wan Safwani Nordin, Fazlina
author_facet	Loke, Xin Ya Imran, Siti A. M. Tye, Gee Jun Wan Kamarul Zaman, Wan Safwani Nordin, Fazlina
author_sort	Loke, Xin Ya
title	Immunomodulation and regenerative capacity of MSCs for long-COVID
title_short	Immunomodulation and regenerative capacity of MSCs for long-COVID
title_full	Immunomodulation and regenerative capacity of MSCs for long-COVID
title_fullStr	Immunomodulation and regenerative capacity of MSCs for long-COVID
title_full_unstemmed	Immunomodulation and regenerative capacity of MSCs for long-COVID
title_sort	immunomodulation and regenerative capacity of mscs for long-covid
publisher	MDPI
publishDate	2021
url	http://eprints.um.edu.my/27916/
_version_	1736834261891153920
score	13.211869

Immunomodulation and regenerative capacity of MSCs for long-COVID

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