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Electrochemical biosensors with aptamer recognition layer for the diagnosis of pathogenic bacteria: Barriers to commercialization and remediation

One of the serious public health threats is pathogenic bacteria due to the lack of affordable and early stage diagnosis and treatment. The existing diagnostic methods are tedious, time-consuming, expensive, and labor-intensive. Therefore, there is an urgent need for achieving simple, low-cost, preci...

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Main Authors: Al Mamun, Mohammad, Wahab, Yasmin Abdul, Hossain, M. A. Motalib, Hashem, Abu, Johan, Mohd Rafie
Format: Article
Published: Elsevier Science Ltd 2021
Subjects:
QD Chemistry
TP Chemical technology
Online Access:http://eprints.um.edu.my/27863/
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spelling my.um.eprints.278632022-04-12T06:54:23Z http://eprints.um.edu.my/27863/ Electrochemical biosensors with aptamer recognition layer for the diagnosis of pathogenic bacteria: Barriers to commercialization and remediation Al Mamun, Mohammad Wahab, Yasmin Abdul Hossain, M. A. Motalib Hashem, Abu Johan, Mohd Rafie QD Chemistry TP Chemical technology One of the serious public health threats is pathogenic bacteria due to the lack of affordable and early stage diagnosis and treatment. The existing diagnostic methods are tedious, time-consuming, expensive, and labor-intensive. Therefore, there is an urgent need for achieving simple, low-cost, precise, and rapid detection methods. Besides a plethora of efforts to meet those promises, electrochemical biosensors technologies with aptamers (synthetic ssDNA or ssRNA) recognition moieties have emerged as a promising sensing platform for bacterial diagnosis. In this review, we have comprehensively discussed the recent advances of different potentiometric and non-potentiometric electrochemical aptasensors emphasizing their surface designs, functionalization, and significant performance for the detection of pathogenic bacteria. At the end of this review, various quality advancements of aptasensors technologies, prospects, challenges, and boundaries of commercialization with research directions have been focused on and summarized. (c) 2021 Elsevier B.V. All rights reserved. Elsevier Science Ltd 2021-12 Article PeerReviewed Al Mamun, Mohammad and Wahab, Yasmin Abdul and Hossain, M. A. Motalib and Hashem, Abu and Johan, Mohd Rafie (2021) Electrochemical biosensors with aptamer recognition layer for the diagnosis of pathogenic bacteria: Barriers to commercialization and remediation. Trac-Trends in Analytical Chemistry, 145. ISSN 0165-9936, DOI https://doi.org/10.1016/j.trac.2021.116458 <https://doi.org/10.1016/j.trac.2021.116458>. 10.1016/j.trac.2021.116458
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
TP Chemical technology
spellingShingle QD Chemistry
TP Chemical technology
Al Mamun, Mohammad
Wahab, Yasmin Abdul
Hossain, M. A. Motalib
Hashem, Abu
Johan, Mohd Rafie
Electrochemical biosensors with aptamer recognition layer for the diagnosis of pathogenic bacteria: Barriers to commercialization and remediation
description One of the serious public health threats is pathogenic bacteria due to the lack of affordable and early stage diagnosis and treatment. The existing diagnostic methods are tedious, time-consuming, expensive, and labor-intensive. Therefore, there is an urgent need for achieving simple, low-cost, precise, and rapid detection methods. Besides a plethora of efforts to meet those promises, electrochemical biosensors technologies with aptamers (synthetic ssDNA or ssRNA) recognition moieties have emerged as a promising sensing platform for bacterial diagnosis. In this review, we have comprehensively discussed the recent advances of different potentiometric and non-potentiometric electrochemical aptasensors emphasizing their surface designs, functionalization, and significant performance for the detection of pathogenic bacteria. At the end of this review, various quality advancements of aptasensors technologies, prospects, challenges, and boundaries of commercialization with research directions have been focused on and summarized. (c) 2021 Elsevier B.V. All rights reserved.
format Article
author Al Mamun, Mohammad
Wahab, Yasmin Abdul
Hossain, M. A. Motalib
Hashem, Abu
Johan, Mohd Rafie
author_facet Al Mamun, Mohammad
Wahab, Yasmin Abdul
Hossain, M. A. Motalib
Hashem, Abu
Johan, Mohd Rafie
author_sort Al Mamun, Mohammad
title Electrochemical biosensors with aptamer recognition layer for the diagnosis of pathogenic bacteria: Barriers to commercialization and remediation
title_short Electrochemical biosensors with aptamer recognition layer for the diagnosis of pathogenic bacteria: Barriers to commercialization and remediation
title_full Electrochemical biosensors with aptamer recognition layer for the diagnosis of pathogenic bacteria: Barriers to commercialization and remediation
title_fullStr Electrochemical biosensors with aptamer recognition layer for the diagnosis of pathogenic bacteria: Barriers to commercialization and remediation
title_full_unstemmed Electrochemical biosensors with aptamer recognition layer for the diagnosis of pathogenic bacteria: Barriers to commercialization and remediation
title_sort electrochemical biosensors with aptamer recognition layer for the diagnosis of pathogenic bacteria: barriers to commercialization and remediation
publisher Elsevier Science Ltd
publishDate 2021
url http://eprints.um.edu.my/27863/
_version_ 1735409532144713728
score 13.211869

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