Development of MTH1-binding nucleotide analogs based on 7,8-dihalogenated 7-Deaza-dG derivatives
MTH1 is an enzyme that hydrolyzes 8-oxo-dGTP, which is an oxidatively damaged nucleobase, into 8-oxo-dGMP in nucleotide pools to prevent its mis-incorporation into genomic DNA. Selective and potent MTH1-binding molecules have potential as biological tools and drug candidates. We recently developed 8...
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| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
MDPI
2021
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/27846/ |
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