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Cathinone: An alkaloid of Catha edulis (Khat) exacerbated hyperglycemia in diabetes-induced rats

Cathinone, the main bioactive alkaloid of Catha edulis (khat), slightly increased the blood sugar levels of healthy animals, while its effect on blood sugar levels of diabetic animals has not yet been reported. This study investigated the in vitro inhibition of cathinone on alpha-amylase and alpha-g...

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Main Authors: Alsalahi, Abdulsamad, Chik, Zamri, Mohamed, Zahurin, Giribabu, Nelli, Alshawsh, Mohammed Abdullah
Format: Article
Published: Elsevier 2021
Subjects:
Q Science (General)
R Medicine
Online Access:http://eprints.um.edu.my/27825/
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spelling my.um.eprints.278252022-03-08T03:22:39Z http://eprints.um.edu.my/27825/ Cathinone: An alkaloid of Catha edulis (Khat) exacerbated hyperglycemia in diabetes-induced rats Alsalahi, Abdulsamad Chik, Zamri Mohamed, Zahurin Giribabu, Nelli Alshawsh, Mohammed Abdullah Q Science (General) R Medicine Cathinone, the main bioactive alkaloid of Catha edulis (khat), slightly increased the blood sugar levels of healthy animals, while its effect on blood sugar levels of diabetic animals has not yet been reported. This study investigated the in vitro inhibition of cathinone on alpha-amylase and alpha-glucosidase as well as its in vivo glycemic effects in diabetes-induced rats. Rats were fed on a high fat diet for five weeks, which then intraperitoneally injected with streptozotocin (30 mg/kg). Diabetic rats were distributed randomly into diabetic control (DC, n = 5), 10 mg/kg glibenclamide-treated group (DG, n = 5), and 1.6 mg/kg cathinone-treated group (CAD, n = 5). Additional healthy untreated rats (n = 5) served as a nondiabetic negative control group. Throughout the experiment, fasting blood sugar (FBS), caloric intake and body weight were recorded weekly. By the 28th day of treatment, rats were euthanized to obtain blood samples and pancreases. The results demonstrated that cathinone exerted a significantly less potent in vitro inhibition than alpha-acarbose against alpha-amylase and alpha-glucosidase. As compared to diabetic control group, cathinone significantly increased FBS of diabetic rats, while insulin levels of diabetic rats significantly decreased. In conclusion, cathinone was unable to induce a substantial in vitro inhibition on alpha-amylase and alpha-glucosidase, while it exacerbated the hyperglycemia of diabetes-induced rats. (C) 2021 Published by Elsevier B.V. on behalf of King Saud University. Elsevier 2021-08 Article PeerReviewed Alsalahi, Abdulsamad and Chik, Zamri and Mohamed, Zahurin and Giribabu, Nelli and Alshawsh, Mohammed Abdullah (2021) Cathinone: An alkaloid of Catha edulis (Khat) exacerbated hyperglycemia in diabetes-induced rats. Saudi Journal of Biological Sciences, 28 (8). pp. 4633-4643. ISSN 1319-562X, DOI https://doi.org/10.1016/j.sjbs.2021.04.072 <https://doi.org/10.1016/j.sjbs.2021.04.072>. 10.1016/j.sjbs.2021.04.072
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
R Medicine
spellingShingle Q Science (General)
R Medicine
Alsalahi, Abdulsamad
Chik, Zamri
Mohamed, Zahurin
Giribabu, Nelli
Alshawsh, Mohammed Abdullah
Cathinone: An alkaloid of Catha edulis (Khat) exacerbated hyperglycemia in diabetes-induced rats
description Cathinone, the main bioactive alkaloid of Catha edulis (khat), slightly increased the blood sugar levels of healthy animals, while its effect on blood sugar levels of diabetic animals has not yet been reported. This study investigated the in vitro inhibition of cathinone on alpha-amylase and alpha-glucosidase as well as its in vivo glycemic effects in diabetes-induced rats. Rats were fed on a high fat diet for five weeks, which then intraperitoneally injected with streptozotocin (30 mg/kg). Diabetic rats were distributed randomly into diabetic control (DC, n = 5), 10 mg/kg glibenclamide-treated group (DG, n = 5), and 1.6 mg/kg cathinone-treated group (CAD, n = 5). Additional healthy untreated rats (n = 5) served as a nondiabetic negative control group. Throughout the experiment, fasting blood sugar (FBS), caloric intake and body weight were recorded weekly. By the 28th day of treatment, rats were euthanized to obtain blood samples and pancreases. The results demonstrated that cathinone exerted a significantly less potent in vitro inhibition than alpha-acarbose against alpha-amylase and alpha-glucosidase. As compared to diabetic control group, cathinone significantly increased FBS of diabetic rats, while insulin levels of diabetic rats significantly decreased. In conclusion, cathinone was unable to induce a substantial in vitro inhibition on alpha-amylase and alpha-glucosidase, while it exacerbated the hyperglycemia of diabetes-induced rats. (C) 2021 Published by Elsevier B.V. on behalf of King Saud University.
format Article
author Alsalahi, Abdulsamad
Chik, Zamri
Mohamed, Zahurin
Giribabu, Nelli
Alshawsh, Mohammed Abdullah
author_facet Alsalahi, Abdulsamad
Chik, Zamri
Mohamed, Zahurin
Giribabu, Nelli
Alshawsh, Mohammed Abdullah
author_sort Alsalahi, Abdulsamad
title Cathinone: An alkaloid of Catha edulis (Khat) exacerbated hyperglycemia in diabetes-induced rats
title_short Cathinone: An alkaloid of Catha edulis (Khat) exacerbated hyperglycemia in diabetes-induced rats
title_full Cathinone: An alkaloid of Catha edulis (Khat) exacerbated hyperglycemia in diabetes-induced rats
title_fullStr Cathinone: An alkaloid of Catha edulis (Khat) exacerbated hyperglycemia in diabetes-induced rats
title_full_unstemmed Cathinone: An alkaloid of Catha edulis (Khat) exacerbated hyperglycemia in diabetes-induced rats
title_sort cathinone: an alkaloid of catha edulis (khat) exacerbated hyperglycemia in diabetes-induced rats
publisher Elsevier
publishDate 2021
url http://eprints.um.edu.my/27825/
_version_ 1735409527219552256
score 13.211869

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