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Sequence analysis on the mitochondrial COXI gene of recent clinical isolates of Plasmodium knowlesi in Klang valley, peninsular Malaysia

The cytochrome oxidase subunit I (COXI) gene sequences of three recent (20072008) clinical Plasmodium knowlesi isolates from Klang Valley, peninsular Malaysia, were determined and compared with those of older (1960's) peninsular Malaysia, recent isolates from Sarawak (on Borneo Island), and an...

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Main Authors: Fong, Mun Yik, Lau, Yee Ling, Chin, Lit Chien, Al-Mekhlafi, A.M.Q.
Format: Article
Language:English
Published: Malaysian Society of Parasitology and Tropical Medicine 2011
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/2722/1/457_-_463_Mun_Yik_Fong.pdf
http://eprints.um.edu.my/2722/
http://www.msptm.org/files/457_-_463_Mun_Yik_Fong.pdf
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spelling my.um.eprints.27222019-11-14T07:58:10Z http://eprints.um.edu.my/2722/ Sequence analysis on the mitochondrial COXI gene of recent clinical isolates of Plasmodium knowlesi in Klang valley, peninsular Malaysia Fong, Mun Yik Lau, Yee Ling Chin, Lit Chien Al-Mekhlafi, A.M.Q. R Medicine The cytochrome oxidase subunit I (COXI) gene sequences of three recent (20072008) clinical Plasmodium knowlesi isolates from Klang Valley, peninsular Malaysia, were determined and compared with those of older (1960's) peninsular Malaysia, recent isolates from Sarawak (on Borneo Island), and an isolate from Thailand. Multiple alignment of the sequences showed that the three clinical isolates were more similar to the older peninsular Malaysia isolates than to those from Sarawak and Thailand. Phylogenetic tree based on the COXI sequences revealed three distinct clusters of P. knowlesi. The first cluster consisted of isolates from peninsular Malaysia, the second consisted of Sarawak isolates and the third composed of the Thailand isolate. The findings of this study highlight the usefulness of mitochondrial COXI gene as a suitable marker for phylogeographic studies of P. knowlesi. Malaysian Society of Parasitology and Tropical Medicine 2011 Article PeerReviewed application/pdf en http://eprints.um.edu.my/2722/1/457_-_463_Mun_Yik_Fong.pdf Fong, Mun Yik and Lau, Yee Ling and Chin, Lit Chien and Al-Mekhlafi, A.M.Q. (2011) Sequence analysis on the mitochondrial COXI gene of recent clinical isolates of Plasmodium knowlesi in Klang valley, peninsular Malaysia. Tropical Biomedicine, 28 (2). pp. 457-463. ISSN 0127-5720 http://www.msptm.org/files/457_-_463_Mun_Yik_Fong.pdf
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine
spellingShingle R Medicine
Fong, Mun Yik
Lau, Yee Ling
Chin, Lit Chien
Al-Mekhlafi, A.M.Q.
Sequence analysis on the mitochondrial COXI gene of recent clinical isolates of Plasmodium knowlesi in Klang valley, peninsular Malaysia
description The cytochrome oxidase subunit I (COXI) gene sequences of three recent (20072008) clinical Plasmodium knowlesi isolates from Klang Valley, peninsular Malaysia, were determined and compared with those of older (1960's) peninsular Malaysia, recent isolates from Sarawak (on Borneo Island), and an isolate from Thailand. Multiple alignment of the sequences showed that the three clinical isolates were more similar to the older peninsular Malaysia isolates than to those from Sarawak and Thailand. Phylogenetic tree based on the COXI sequences revealed three distinct clusters of P. knowlesi. The first cluster consisted of isolates from peninsular Malaysia, the second consisted of Sarawak isolates and the third composed of the Thailand isolate. The findings of this study highlight the usefulness of mitochondrial COXI gene as a suitable marker for phylogeographic studies of P. knowlesi.
format Article
author Fong, Mun Yik
Lau, Yee Ling
Chin, Lit Chien
Al-Mekhlafi, A.M.Q.
author_facet Fong, Mun Yik
Lau, Yee Ling
Chin, Lit Chien
Al-Mekhlafi, A.M.Q.
author_sort Fong, Mun Yik
title Sequence analysis on the mitochondrial COXI gene of recent clinical isolates of Plasmodium knowlesi in Klang valley, peninsular Malaysia
title_short Sequence analysis on the mitochondrial COXI gene of recent clinical isolates of Plasmodium knowlesi in Klang valley, peninsular Malaysia
title_full Sequence analysis on the mitochondrial COXI gene of recent clinical isolates of Plasmodium knowlesi in Klang valley, peninsular Malaysia
title_fullStr Sequence analysis on the mitochondrial COXI gene of recent clinical isolates of Plasmodium knowlesi in Klang valley, peninsular Malaysia
title_full_unstemmed Sequence analysis on the mitochondrial COXI gene of recent clinical isolates of Plasmodium knowlesi in Klang valley, peninsular Malaysia
title_sort sequence analysis on the mitochondrial coxi gene of recent clinical isolates of plasmodium knowlesi in klang valley, peninsular malaysia
publisher Malaysian Society of Parasitology and Tropical Medicine
publishDate 2011
url http://eprints.um.edu.my/2722/1/457_-_463_Mun_Yik_Fong.pdf
http://eprints.um.edu.my/2722/
http://www.msptm.org/files/457_-_463_Mun_Yik_Fong.pdf
_version_ 1651867310613331968
score 13.211869

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