封面圖片

Autism spectrum disorder and vitamin D status: A cross-sectional study of children in a developing country in Southeast Asia

Background: Determine the prevalence and risk factors of vitamin D deficiency (<35 nmol/L) in children with autism spectrum disorder (ASD); and explore the association between vitamin D deficiency with ASD severity and behavioural symptoms. Method: Cross-sectional study of children with ASD at a...

全面介紹

Saved in:
書目詳細資料
Main Authors: Jayanath, Subhashini, Fong, Choong Yi, Sarvananthan, Rajini
格式: Article
出版: Elsevier Sci Ltd 2021
主題:
BF Psychology
R Medicine
在線閱讀:http://eprints.um.edu.my/27073/
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!
id my.um.eprints.27073
record_format eprints
spelling my.um.eprints.270732022-03-11T04:53:38Z http://eprints.um.edu.my/27073/ Autism spectrum disorder and vitamin D status: A cross-sectional study of children in a developing country in Southeast Asia Jayanath, Subhashini Fong, Choong Yi Sarvananthan, Rajini BF Psychology R Medicine Background: Determine the prevalence and risk factors of vitamin D deficiency (<35 nmol/L) in children with autism spectrum disorder (ASD); and explore the association between vitamin D deficiency with ASD severity and behavioural symptoms. Method: Cross-sectional study of children with ASD at a tertiary hospital. Children with vitamin D deficiency (<35.0 nmol/L) were treated (1200IU cholecalciferol, daily for 3 months). ASD severity was determined via the Childhood Autism Rating Scale, 2nd Edition (CARS-2); and behavioural symptoms via the Aberrant Behaviour Checklist, 2nd Edition (ABC-2). Scores were compared between the vitamin D deficient and non-deficient groups. Results: There were 103 participants (85.4 % male). Mean age: 6.2 years (SD = 2.4), 19 % were vitamin D deficient and 42 % were insufficient. Mean vitamin D concentration was 45.8 nmol/L (SD = 13.5). Female gender was significantly associated with vitamin D deficiency (OR 5.05, 95 % CI: 1.56, 16.31, p = 0.007). Post-vitamin D treatment, there was a significant reduction in CARS-2 scores (p < 0.05), but not ABC-2 scores. Conclusions: Nearly two-thirds (61 %) of Malaysian children with ASD have vitamin D deficiency (19 %) and insufficiency (42 %). Vitamin D treatment among vitamin D deficient children with ASD resulted in improvement in ASD symptom severity but not behavioural symptoms. Elsevier Sci Ltd 2021-06 Article PeerReviewed Jayanath, Subhashini and Fong, Choong Yi and Sarvananthan, Rajini (2021) Autism spectrum disorder and vitamin D status: A cross-sectional study of children in a developing country in Southeast Asia. Research in Autism Spectrum Disorders, 84. ISSN 1750-9467, DOI https://doi.org/10.1016/j.rasd.2021.101786 <https://doi.org/10.1016/j.rasd.2021.101786>. 10.1016/j.rasd.2021.101786
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic BF Psychology
R Medicine
spellingShingle BF Psychology
R Medicine
Jayanath, Subhashini
Fong, Choong Yi
Sarvananthan, Rajini
Autism spectrum disorder and vitamin D status: A cross-sectional study of children in a developing country in Southeast Asia
description Background: Determine the prevalence and risk factors of vitamin D deficiency (<35 nmol/L) in children with autism spectrum disorder (ASD); and explore the association between vitamin D deficiency with ASD severity and behavioural symptoms. Method: Cross-sectional study of children with ASD at a tertiary hospital. Children with vitamin D deficiency (<35.0 nmol/L) were treated (1200IU cholecalciferol, daily for 3 months). ASD severity was determined via the Childhood Autism Rating Scale, 2nd Edition (CARS-2); and behavioural symptoms via the Aberrant Behaviour Checklist, 2nd Edition (ABC-2). Scores were compared between the vitamin D deficient and non-deficient groups. Results: There were 103 participants (85.4 % male). Mean age: 6.2 years (SD = 2.4), 19 % were vitamin D deficient and 42 % were insufficient. Mean vitamin D concentration was 45.8 nmol/L (SD = 13.5). Female gender was significantly associated with vitamin D deficiency (OR 5.05, 95 % CI: 1.56, 16.31, p = 0.007). Post-vitamin D treatment, there was a significant reduction in CARS-2 scores (p < 0.05), but not ABC-2 scores. Conclusions: Nearly two-thirds (61 %) of Malaysian children with ASD have vitamin D deficiency (19 %) and insufficiency (42 %). Vitamin D treatment among vitamin D deficient children with ASD resulted in improvement in ASD symptom severity but not behavioural symptoms.
format Article
author Jayanath, Subhashini
Fong, Choong Yi
Sarvananthan, Rajini
author_facet Jayanath, Subhashini
Fong, Choong Yi
Sarvananthan, Rajini
author_sort Jayanath, Subhashini
title Autism spectrum disorder and vitamin D status: A cross-sectional study of children in a developing country in Southeast Asia
title_short Autism spectrum disorder and vitamin D status: A cross-sectional study of children in a developing country in Southeast Asia
title_full Autism spectrum disorder and vitamin D status: A cross-sectional study of children in a developing country in Southeast Asia
title_fullStr Autism spectrum disorder and vitamin D status: A cross-sectional study of children in a developing country in Southeast Asia
title_full_unstemmed Autism spectrum disorder and vitamin D status: A cross-sectional study of children in a developing country in Southeast Asia
title_sort autism spectrum disorder and vitamin d status: a cross-sectional study of children in a developing country in southeast asia
publisher Elsevier Sci Ltd
publishDate 2021
url http://eprints.um.edu.my/27073/
_version_ 1735409495902781440
score 13.250246

相似書籍