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Proof-of-concept of detection of counterfeit medicine through polymeric materials analysis of plastics packaging

The detection of counterfeit pharmaceuticals is always a major challenge, but the early detection of counterfeit medicine in a country will reduce the fatal risk among consumers. Technically, fast laboratory testing is vital to develop an effective surveillance and monitoring system of counterfeit m...

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Main Authors: Salim, Mohammad Rizalmazli, Widodo, Riyanto Teguh, Noordin, Mohamed Ibrahim
Format: Article
Published: MDPI 2021
Subjects:
RS Pharmacy and materia medica
Online Access:http://eprints.um.edu.my/27053/
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spelling my.um.eprints.270532022-05-14T04:23:39Z http://eprints.um.edu.my/27053/ Proof-of-concept of detection of counterfeit medicine through polymeric materials analysis of plastics packaging Salim, Mohammad Rizalmazli Widodo, Riyanto Teguh Noordin, Mohamed Ibrahim RS Pharmacy and materia medica The detection of counterfeit pharmaceuticals is always a major challenge, but the early detection of counterfeit medicine in a country will reduce the fatal risk among consumers. Technically, fast laboratory testing is vital to develop an effective surveillance and monitoring system of counterfeit medicines. This study proposed the combination of Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) and Differential Scanning Calorimetry (DSC) for the quick detection of counterfeit medicines, through the polymer analysis of blister packaging materials. A sample set containing three sets of original and counterfeit medicine was analyzed using ATR-FTIR and DSC, while the spectra from ATR-FTIR were employed as a fingerprint for the polymer characterization. Intending to analyze the polymeric material of each sample, DSC was set at a heating rate of 10 degrees C min(-l) and within a temperature range of 0-400 degrees C, with nitrogen as a purge gas at a flow rate of 20 mL min(-1). The ATR-FTIR spectra revealed the chemical characteristics of the plastic packaging of fake and original medicines. Further analysis of the counterfeit medicine's packaging with DSC exhibited a distinct difference from the original due to the composition of polymers in the packaging material used. Overall, this study confirmed that the rapid analysis of polymeric materials through ATR-FTIR and comparing DSC thermograms of the plastic in their packaging effectively distinguished counterfeit drug products. MDPI 2021-07 Article PeerReviewed Salim, Mohammad Rizalmazli and Widodo, Riyanto Teguh and Noordin, Mohamed Ibrahim (2021) Proof-of-concept of detection of counterfeit medicine through polymeric materials analysis of plastics packaging. Polymers, 13 (13). ISSN 2073-4360, DOI https://doi.org/10.3390/polym13132185 <https://doi.org/10.3390/polym13132185>. 10.3390/polym13132185
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Salim, Mohammad Rizalmazli
Widodo, Riyanto Teguh
Noordin, Mohamed Ibrahim
Proof-of-concept of detection of counterfeit medicine through polymeric materials analysis of plastics packaging
description The detection of counterfeit pharmaceuticals is always a major challenge, but the early detection of counterfeit medicine in a country will reduce the fatal risk among consumers. Technically, fast laboratory testing is vital to develop an effective surveillance and monitoring system of counterfeit medicines. This study proposed the combination of Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) and Differential Scanning Calorimetry (DSC) for the quick detection of counterfeit medicines, through the polymer analysis of blister packaging materials. A sample set containing three sets of original and counterfeit medicine was analyzed using ATR-FTIR and DSC, while the spectra from ATR-FTIR were employed as a fingerprint for the polymer characterization. Intending to analyze the polymeric material of each sample, DSC was set at a heating rate of 10 degrees C min(-l) and within a temperature range of 0-400 degrees C, with nitrogen as a purge gas at a flow rate of 20 mL min(-1). The ATR-FTIR spectra revealed the chemical characteristics of the plastic packaging of fake and original medicines. Further analysis of the counterfeit medicine's packaging with DSC exhibited a distinct difference from the original due to the composition of polymers in the packaging material used. Overall, this study confirmed that the rapid analysis of polymeric materials through ATR-FTIR and comparing DSC thermograms of the plastic in their packaging effectively distinguished counterfeit drug products.
format Article
author Salim, Mohammad Rizalmazli
Widodo, Riyanto Teguh
Noordin, Mohamed Ibrahim
author_facet Salim, Mohammad Rizalmazli
Widodo, Riyanto Teguh
Noordin, Mohamed Ibrahim
author_sort Salim, Mohammad Rizalmazli
title Proof-of-concept of detection of counterfeit medicine through polymeric materials analysis of plastics packaging
title_short Proof-of-concept of detection of counterfeit medicine through polymeric materials analysis of plastics packaging
title_full Proof-of-concept of detection of counterfeit medicine through polymeric materials analysis of plastics packaging
title_fullStr Proof-of-concept of detection of counterfeit medicine through polymeric materials analysis of plastics packaging
title_full_unstemmed Proof-of-concept of detection of counterfeit medicine through polymeric materials analysis of plastics packaging
title_sort proof-of-concept of detection of counterfeit medicine through polymeric materials analysis of plastics packaging
publisher MDPI
publishDate 2021
url http://eprints.um.edu.my/27053/
_version_ 1735409493294972928
score 13.211869

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